FB2026_02 , released June 18, 2026
Allele: Dmel\pdm2Δmiti.Hsp83
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General Information
Symbol
Dmel\pdm2Δmiti.Hsp83
Species
D. melanogaster
Name
FlyBase ID
FBal0039736
Feature type
allele
Associated gene
Dmel\pdm2
Associated Insertion(s)
Carried in Construct
P{hsp83-Δmiti}
Key Links
Transgenic product class
dominant_negative_variant
(Bhat and Schedl, 1994)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Bhat and Schedl, 1994)
Mutagen
in vitro construct
(Bhat and Schedl, 1994)
Progenitor genotype
Carried in construct
P{hsp83-Δmiti}
Cytology
Description

A 1.2kb PstI fragment from the pdm2 cDNA is expressed from an Hsp83 promoter. This fragment lacks usual ATG codon, and if the available internal ATG is used for initiation the resulting product would lack 277 amino acids from the N terminus. Only 8 amino acids upstream of the POU-specific domain will be included in the truncated protein.

(Bhat and Schedl, 1994)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp83
Encoded product / tool
pdm2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos carrying two copies of pdm2Δmiti.Hsp83 usually show deletions in abdominal segment 2 and sometimes defects in abdominal segment 6 and the head. Reducing the dose of pdm2+ in the presence of a single copy of pdm2Δmiti.Hsp83 reveals similar phenotypes. The transgene interferes with the GMC1 to RP2/sib lineage, and RP2 neurons are missing from the CNS of mutant embryos.

      (Bhat and Schedl, 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pdm2Δmiti.Hsp83
      Name Synonyms
      Secondary FlyBase IDs
        References (1)