FlyBase Allele Report: Dmel\al[130]

General Information

Symbol

Dmel\al¹³⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0027956

Feature type

allele

Associated gene

Dmel\al

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

Progenitor genotype

Caused by aberration

In(2L)al¹³⁰

Cytology

Description

Inversion breakpoint resides between the Pro- and charged domain of the al gene product at position 9332.

(Schneitz et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Schneitz et al., 1993)

visible

(Schneitz et al., 1993)

visible (with al^ush)

(Wehn and Campbell, 2006)

visible | recessive

(Campbell and Tomlinson, 1998)

Phenotype Manifest In

arista

(Schneitz et al., 1993)

arista (with al^ush)

(Wehn and Campbell, 2006, Campbell, 2005)

scutellum

(Schneitz et al., 1993)

unguis

(Campbell and Tomlinson, 1998)

Detailed Description

Statement

Reference

al¹³⁰/al^ush animals have an almost full length arista.

(Wehn and Campbell, 2006)

In al¹³⁰/al^ush mutants, the arista is very slightly reduced in length.

(Campbell, 2005)

Homozygous legs have a rudimentary claw and the pulvillus is present. The tarsal segments are of normal size.

(Campbell and Tomlinson, 1998)

Arista and scutellum are reduced in size. Introduction of a 13.3kb genomic al fragment in P{al-13.3} causes partial rescue of the scutellum phenotype and complete rescue of lethality, though the aristae are still reduced in size. Homozygous flies that carry one copy of al^B38 in P{al-13.3} display gaps in the most proximal part of the second longitudinal wing vein and the wing blade is bent downward at its posterior tip.

(Schneitz et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

al^ush/al¹³⁰ has visible phenotype, enhanceable by Gug[+]/Gug^Eal15

(Wehn and Campbell, 2006)

al^ush/al¹³⁰ has visible phenotype, enhanceable by sbb[+]/sbb^Eal17

(Wehn and Campbell, 2006)

al^ush/al¹³⁰ has visible phenotype, enhanceable by gro^Eal13/gro[+]

(Wehn and Campbell, 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

al^ush/al¹³⁰ has arista phenotype, enhanceable by Gug[+]/Gug^Eal15

(Wehn and Campbell, 2006)

al^ush/al¹³⁰ has arista phenotype, enhanceable by sbb[+]/sbb^Eal17

(Wehn and Campbell, 2006)

al^ush/al¹³⁰ has arista phenotype, enhanceable by gro^Eal13/gro[+]

(Wehn and Campbell, 2006)

al^ush/al¹³⁰ has arista phenotype, enhanceable by Df(3R)e-19

(Campbell, 2005)

al^ush/al¹³⁰ has arista phenotype, enhanceable by Df(3R)e-BS2

(Campbell, 2005)

al^ush/al¹³⁰ has arista phenotype, enhanceable by C15²/C15[+]

(Campbell, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The short arista al^ush/al¹³⁰ phenotype is enhanced in C15²/+ flies. This phenotype is also enhanced when flies carry either the Df(3R)e-19 or the Df(3R)e-BS2 deficiency; both of which remove the C15 gene.

(Campbell, 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3446