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Citation
Ludlow, C., Choy, R., Blochlinger, K. (1996). Functional analysis of Drosophila and mammalian cut proteins in flies.  Dev. Biol. 178(1): 149--159.
FlyBase ID
FBrf0089730
Publication Type
Research paper
Abstract

The cut locus acts as a bimodal switch controlling cell fate in the peripheral nervous system of Drosophila and is also required for the development of the wing margin. It encodes a protein, Cut, that contains an atypical homeodomain and three copies of a new motif which can bind DNA in vitro. The human protein CDP and the murine protein Cux have recently been isolated as DNA-binding activities and they are structurally related to Cut. We show that ectopic expression of Cut, CDP, or Cux similarly affects embryonic sensory organ development and can rescue a wing scalloping mutant phenotype associated with loss of cut expression along the prospective wing margins. This suggests that the function of Cut is evolutionarily conserved.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Biol.
    Title
    Developmental Biology
    Publication Year
    1959-
    ISBN/ISSN
    0012-1606
    Data From Reference
    Alleles (8)
    Genes (5)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (3)