FlyBase Allele Report: Dmel\Tm2[L2]

General Information

Symbol

Dmel\Tm2^L2

Species

D. melanogaster

Name

FlyBase ID

FBal0061573

Feature type

allele

Associated gene

Dmel\Tm2

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kreuz et al., 1996)

Progenitor genotype

Cytology

Description

Mutation within the second exon.

(Kreuz et al., 1996)

Amino acid replacement: Q92term.

(Kreuz et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:15,312,729..15,312,729 [+]

Nucleotide change:

C15312729T

Amino acid change:

Reported amino acid change:

Q92term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kreuz et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Kreuz et al., 1996)

lethal - all die during embryonic stage | recessive

(Kreuz et al., 1996)

some die during embryonic stage | recessive

(Kreuz et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Tm2^L2/Tm2[+] is a non-suppressor of visible phenotype of wupA^hdp-2

(Naimi et al., 2001)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Tm2^L2/Tm2[+] is a non-suppressor of indirect flight muscle cell phenotype of wupA^hdp-2

(Naimi et al., 2001)

Tm2^L2/Tm2[+] is a non-suppressor of wing phenotype of wupA^hdp-2

(Naimi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The upheld wing phenotype of wupA^hdp-2 flies is not suppressed by Tm2^L2/+. The IFM hypercontraction phenotype seen in wupA^hdp-2 flies is not suppressed by Tm2^L2/+.

(Naimi et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tm2^L2 is rescued by Tm2^+tΔ-2500

(Kreuz et al., 1996)

Comments

The flightless behaviour and recessive lethality caused by Tm2^L2 are completely rescued by Tm2^+tΔ-2500.

(Kreuz et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

(Naimi et al., 2001, Vigoreaux, 2001)

Tm2^L2

Tm2^nc99Eb-L2

l(3)nc99Eb^L2

Name Synonyms

Secondary FlyBase IDs

FBal0032026

References (4)

Report Sections

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