FlyBase Allele Report: Dmel\Tm1[02299]

(Vereshchagina et al., 2004, Li and Gao, 2003, Zraly et al., 2002, Spradling et al., 1999, Harvie et al., 1998, Tetzlaff et al., 1996, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | recessive

(Tetzlaff et al., 1996)

abnormal neuroanatomy

(Li and Gao, 2003)

abnormal neuroanatomy (with Tm1^S130510)

(Li and Gao, 2003)

lethal | recessive

(Zraly et al., 2002, Spradling et al., 1999, Harvie et al., 1998)

lethal - all die before end of larval stage | recessive

(Tetzlaff et al., 1996)

some die during larval stage | recessive

(Tetzlaff et al., 1996)

Phenotype Manifest In

border follicle cell

(Kim et al., 2011)

dorsal multidendritic neuron ddaE & dendrite

(Li and Gao, 2003)

dorsal multidendritic neuron ddaE & dendrite (with Tm1^S130510)

(Li and Gao, 2003)

embryonic/larval pharynx | embryonic stage

(Tetzlaff et al., 1996)

primordial germ cell

(Tetzlaff et al., 1996)

Detailed Description

Statement

Reference

11.5% of heterozygous border follicle cell clusters show defects in migration.

(Kim et al., 2011)

The dendrites of ddaE neurons overextend in Tm1⁰²²⁹⁹/Tm1^S130510 transheterozygotes and Tm1⁰²²⁹⁹ homozygotes.

(Li and Gao, 2003)

Homozygous larvae have a defect in head morphogenesis, the pharynx is not retracted into the body during head involution. A protruding pharyngeal mass means individuals cannot feed due to an inability to suck food into the mouth atrium. Embryos lacking maternal Tm1 are defective in pole cell formation.

(Tetzlaff et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Tm1[+]/Tm1⁰²²⁹⁹ is an enhancer of visible phenotype of br¹

(Ward et al., 2003)

Suppressor of

Statement

Reference

Tm1⁰²²⁹⁹ is a suppressor of visible phenotype of MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

Tm1⁰²²⁹⁹ is a suppressor of lethal | male phenotype of flw⁶

(Vereshchagina et al., 2004)

Tm1⁰²²⁹⁹ is a suppressor of lethal | male phenotype of flw^G0172

(Vereshchagina et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Tm1⁰²²⁹⁹ is an enhancer of wing phenotype of MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

Tm1[+]/Tm1⁰²²⁹⁹ is an enhancer of leg phenotype of br¹

(Ward et al., 2003)

NOT Enhancer of

Statement

Reference

Tm1[+]/Tm1⁰²²⁹⁹ is a non-enhancer of indirect flight muscle cell phenotype of DAAM^Ex1

(Molnár et al., 2014)

NOT Suppressor of

Statement

Reference

Tm1[+]/Tm1⁰²²⁹⁹ is a non-suppressor of indirect flight muscle cell phenotype of DAAM^Ex1

(Molnár et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The mild indirect muscle phenotype seen in DAAM^Ex1 mutants is not altered by Tm1⁰²²⁹⁹/+.

(Molnár et al., 2014)

Expression of psidin^Scer\UAS.cKa under the control of Scer\GAL4^slbo.2.6 in a Tm1⁰²²⁹⁹ heterozygous background results in border cell migration defects (26.7%).

(Kim et al., 2011)

The amount of blistering and crumpling of wings in flies expressing MYPT-75D^{F117A.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 is suppressed by Tm1⁰²²⁹⁹.

(Vereshchagina et al., 2004)

Dominantly enhances the frequency of br¹ mutant animals with malformed legs.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Tm1^Su(flw)4

(Vereshchagina et al., 2004)

Tm1^L4120a

(BDGP Project Members, 1994-1999)

Tm1^j13E8

(BDGP Project Members, 1994-1999)

Tm1^s2047

(BDGP Project Members, 1994-1999)

Tm1^s3601

(BDGP Project Members, 1994-1999)

Tm1^s2958

(BDGP Project Members, 1994-1999)

Tm1¹⁰⁶¹⁷

(BDGP Project Members, 1994-1999)

Tm1⁰⁹⁹⁶⁵

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11564

ry⁵⁰⁶ P{PZ}Tm1⁰²²⁹⁹/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Abolishes expression of cytoplasmic isoform but does not affect muscle isoforms.

(Li and Gao, 2003)

Complements: Hsc70-4⁰³⁵⁵⁰. Complements: Atx2⁰⁶⁴⁹⁰.

(BDGP Project Members, 1994-1999)

Mobilisation of the P{PZ} element resulted in reversion of the feeding defect, larvae develop into normal adults. Lack of zygotic Tm1 results in the specific head defect, lack of maternal Tm1 affects germ cell formation.

(Tetzlaff et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Tm1⁰²²⁹⁹

(Molnár et al., 2014)

Tm1^PZ2299

(Kim et al., 2011)

cTmIIP

(Tetzlaff et al., 1996)

l(3)02299

(Spradling et al., 1999)

l(3)2299

(Ward et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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