FlyBase Allele Report: Dmel\MYPT-75D[F117A.UAS]

General Information

Symbol

Dmel\MYPT-75D^F117A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0182816

Feature type

allele

Associated gene

Dmel\MYPT-75D

Associated Insertion(s)

Carried in Construct

P{UAS-MYPT-75D.F117A}

Key Links

Transgenic product class

missense_variant

(Vereshchagina et al., 2004)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Vereshchagina et al., 2004)

Mutagen

in vitro construct

(Vereshchagina et al., 2004)

Progenitor genotype

MYPT-75D^{HM.UAS.Tag:MYC,Tag:polyHis}

(Vereshchagina et al., 2004)

Carried in construct

P{UAS-MYPT-75D.F117A}

Cytology

Description

Amino acid replacement: F117A.

(Vereshchagina et al., 2004)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

MYPT-75D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | somatic clone, with Scer\GAL4^FRT.Act5C

(Sun et al., 2011)

visible, with Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

Phenotype Manifest In

oocyte | somatic clone, with Scer\GAL4^FRT.Act5C

(Sun et al., 2011)

wing, with Scer\GAL4^Bx-MS1096

(Vereshchagina et al., 2004)

Detailed Description

Statement

Reference

Expression of MYPT-75D^{F117A.Scer\UAS} in follicle cells under the control of Scer\GAL4^{Scer\FRT.Act5C} produces oocyte polarity defects.

(Sun et al., 2011)

The wings of flies expressing MYPT-75D^{F117A.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 are blistered and crumpled.

(Vereshchagina et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by sqh^E20.E21

(Vereshchagina et al., 2004)

Suppressed by

Statement

Reference

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by Tm1⁰²²⁹⁹

(Vereshchagina et al., 2004)

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by sqh^{A20.A21.Tag:FLAG}

(Vereshchagina et al., 2004)

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by zip¹

(Vereshchagina et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has wing phenotype, enhanceable by sqh^E20.E21

(Vereshchagina et al., 2004)

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has wing phenotype, enhanceable by Tm1⁰²²⁹⁹

(Vereshchagina et al., 2004)

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has wing phenotype, enhanceable by zip¹

(Vereshchagina et al., 2004)

Suppressed by

Statement

Reference

MYPT-75D^F117A.UAS, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by sqh^{A20.A21.Tag:FLAG}

(Vereshchagina et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The amount of blistering and crumpling of wings in flies expressing MYPT-75D^{F117A.Scer\UAS} under the control of Scer\GAL4^Bx-MS1096 is suppressed by sqh^{A20.A21.T:Zzzz\FLAG}, zip¹ and Tm1⁰²²⁹⁹. However, the MYPT-75D^{F117A.Scer\UAS}>Scer\GAL4^Bx-MS1096 wing phenotype is enhanced when flies also express sqh^E20.E21.

(Vereshchagina et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

24099

w^*; P{UAS-MYPT-75D.F117A}AT1

24100

w^*; P{UAS-MYPT-75D.F117A}AT3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

MYPT-75D^{F117A.Scer\UAS}

MYPT-75D^F117A.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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