FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tm1S130510
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General Information
Symbol
Dmel\Tm1S130510
Species
D. melanogaster
Name
FlyBase ID
FBal0129369
Feature type
allele
Associated gene
Dmel\Tm1
Associated Insertion(s)
P{lacW}Tm1S130510
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Deak et al., 1997)
P-element activity
(Szeged Stock Center, 1998-)
Progenitor genotype
Associated Insertion(s)
P{lacW}Tm1S130510
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dendritic arborising neuron & dendrite

      (Li and Gao, 2003)

      dendritic arborising neuron & dendrite (with Tm1el4)

      (Li and Gao, 2003)

      dorsal multidendritic neuron ddaC & dendrite | somatic clone

      (Li and Gao, 2003)

      dorsal multidendritic neuron ddaE & dendrite

      (Li and Gao, 2003)

      dorsal multidendritic neuron ddaE & dendrite (with Tm102299)

      (Li and Gao, 2003)

      dorsal multidendritic neuron ddaE & dendrite (with Tm1el4)

      (Li and Gao, 2003)
      Detailed Description
      Statement
      Reference

      The dendrites of dorsal cluster dendritic arborization (DA) neurons and ddaE neurons overextend in Tm1S130510 mutants. This phenotype also occurs in Tm1S130510/Tm1el4 transheterozygotes and Tm1S130510/Tm102299 transheterozygotes. The amount and length of lateral branches that extend from the dorsal dendrites is greater in Tm1S130510/Tm1el4 transheterozygotes than in wild-type embryos. Third larval instar dendritic arborization ddaC neurons which are mutant for Tm1S130510 (generated using the MARCM technique) show significantly larger dendritic fields than neighbouring wild-type neurons, showing that the neurons are cell-autonomous.

      (Li and Gao, 2003)

      Early lethal.

      (Szeged Stock Center, 1998-, Deak et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Tm1el4/Tm1S130510 has abnormal neuroanatomy phenotype, enhanceable by stan[+]/stan51

      (Li and Gao, 2003)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Tm1el4/Tm1S130510 has dorsal multidendritic neuron ddaE & dendrite phenotype, enhanceable by stan[+]/stan51

      (Li and Gao, 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos that are Tm1S130510/Tm1el4 transheterozygotes in a stan51/+ background have an enhanced dendritic overextension phenotype in ddaE neurons.

      (Li and Gao, 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Lack of zygotic Tm1 results in the specific head defect, lack of maternal Tm1 affects germ cell formation.

      (Li and Gao, 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      1305/10
      (Deak et al., 1997)
      Tm1S130510
      l(3)S130510S130510
      (Szeged Stock Center, 1998-)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)