FlyBase Allele Report: Dmel\Tm1[ZCL0722]

General Information

Symbol

Dmel\Tm1^ZCL0722

Species

D. melanogaster

Name

FlyBase ID

FBal0277253

Feature type

allele

Associated gene

Dmel\Tm1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

border follicle cell

(Kim et al., 2011)

border follicle cell | somatic clone

(Kim et al., 2011)

Detailed Description

Statement

Reference

Neurons in primary neuron cultures derived from mutant embryos have normal sized lamellipodia and normal length neurites.

Homozygous olfactory receptor neuron (ORN) clones show no defects in the axonal targeting pattern or number of Or59c-expressing ORNs.

(Stephan et al., 2012)

9.7% of heterozygous border follicle cell clusters show defects in migration. Homozygous border follicle cells show defects in migration.

(Kim et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tm1^ZCL0722 is a suppressor | partially | somatic clone of abnormal neuroanatomy | somatic clone | adult stage phenotype of psidin^55D4

(Stephan et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tm1^ZCL0722 has border follicle cell | somatic clone phenotype, suppressible | partially | somatic clone by psidin^55D4

(Kim et al., 2011)

Suppressor of

Statement

Reference

Tm1^ZCL0722 is a suppressor of lamellipodium phenotype of psidin^55D4

(Stephan et al., 2012)

Tm1^ZCL0722 is a suppressor | partially | somatic clone of adult olfactory receptor neuron Or59c | somatic clone phenotype of psidin^55D4

(Stephan et al., 2012)

Tm1^ZCL0722 is a suppressor | partially | somatic clone of border follicle cell | somatic clone phenotype of psidin^55D4

(Kim et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The reduction in lamellipodia size and increase in neurite length which is seen in neurons in primary neuron cultures derived from psidin^55D4 embryos are suppressed if the embryos are also mutant for Tm1^ZCL0722.

psidin^55D4 Tm1^ZCL0722 double mutant Or59c olfactory receptor neuron (ORNs) show a marked reduction in the penetrance and severity of axonal targeting defects compared to psidin^55D4 single mutant ORNs, but the reduction in the number of Or59c ORNs seen in psidin^55D4 single mutant ORNs is not rescued in the double mutants.

(Stephan et al., 2012)

Expression of psidin^Scer\UAS.cKa under the control of Scer\GAL4^slbo.2.6 in a Tm1^ZCL0722 heterozygous background results in border cell migration defects (45.1%).

Border follicle cells simultaneously homozygous for both Tm1^ZCL0722 and psidin^55D4 show less severe migration defects than single mutant border follicle cells.

(Kim et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tm1^ZCL0722

(Kim et al., 2011)

tm1^ZCL0722

(Stephan et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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