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General Information
Symbol
Dmel\dor8
Species
D. melanogaster
Name
FlyBase ID
FBal0002736
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dorl
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Linked to:
EcoRI-BamHI restriction fragment
Comment:

Insertion of DNA at least 4.3kb in length. Insertion site localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of DNA at least 4.3kb in length.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous mushroom body gamma neuron clones show normal axon pruning.

dor8 clones exhibit an endosome clustering phenotype.

Homozygous clones in the eye lack almost all pigmentation.

Late larval lethal.

Homozygous clones in the eye lack pigmentation. Only minor defects are seen in the composition of the ommatidia. The majority of rhabdomeres are normal. Giant multivesicular bodies (MVBs) with diameters up to 3μm are seen in mutant pigment cells. Many of the internal vesicles in these structures appear coated (this is not seen in wild-type rhabdomeres). Smaller MVBs are seen in mutant photoreceptor cells (these are not seen in wild-type cells).

Homozygous larvae die 90-100 hours after hatching. Heterozygotes with Df(1)RA19 die in the middle of the third instar.

Malpighian tubule colour: nearly colourless except at base.

A gut abnormality appears at 65 hr that results in obliteration of gut lumen and loss of all food material.

Melanotic tumors develop.

RK2. Male larvae die 90-100 hr after hatching. dor8/dor1 has orange eyes like dor1/dor1, as well as the sterility effects (Clancy; Redfeld and Schultz).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The dor4/dor8 transheterozygote exhibits the same phenotype as the dor4 homozygote.

Images (0)
Mutant
Wild-type
Stocks (4)
Notes on Origin
Discoverer

Bridges, 1 Jan 1915.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (33)