FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dorC107
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General Information
Symbol
Dmel\dorC107
Species
D. melanogaster
Name
FlyBase ID
FBal0247336
Feature type
allele
Associated gene
Dmel\dor
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Chi et al., 2010)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T107G.

(Chi et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,667,083..1,667,083 [+]
Nucleotide change:

T1667083G

Amino acid change:

Y615term | dor-PA

Reported amino acid change:

Y615term

Comment:

Nucleotide substitution inferred from reported amino acid change. Position of mutation on reference sequence inferred by FlyBase curator.

(Chi et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA with Ras85DV12.UAS
      (Chi et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When compared with wld-type controls, clones of dorC107 cells display no visible growth advantages or morphology defects in either larval or adult stages. However, severe loss of red pigments is observed in dorC107 clones in the adult eye, indicating a cell-autonomous pigmentation defect.

      (Chi et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      Statement
      Reference

      dorC107 is an enhancer of hyperplasia phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Act5C

      (Chi et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Starting on day 8 after egg laying (AEL), Ras85DV12.Scer\UAS, Scer\GAL4Scer\FRT.Act5C tumours with a homozygous dorC107 background exhibit enhanced outgrowth when compared with Ras85DV12.Scer\UAS, Scer\GAL4Scer\FRT.Act5C controls. On day 14 AEL, these double mutant tumour cells clearly invade into the ventral nerve cord with a high frequency. On day 18 AEL, the dramatically overgrown double mutant tumours occupy about one-quarter volume of the larvae body and completely enveloped ventral nerve cord. Occasionally, tumour cells are also found in the gut and the trachea of the double mutant larvae, indicating secondary tumour formation in distal organs. All double mutant larvae die prior to pupation.

      Expression of bskDN.Scer\UAS in Ras85DV12.Scer\UAS, Scer\GAL4Scer\FRT.Act5C /dorC107 clones suppresses the enhanced tumour overgrowth and metastasis.

      (Chi et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dorC107
      (Chi et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)