FB2025_02 , released April 17, 2025
Allele: Dmel\dor1-1002.UAS
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General Information
Symbol
Dmel\dor1-1002.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0102757
Feature type
allele
Associated gene
Dmel\dor
Associated Insertion(s)
Carried in Construct
P{UAS-dor.1-1002}
Also Known As
UAS-dor
Key Links
Transgenic product class
wild_type
(Sevrioukov et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sevrioukov et al., 1999)
Mutagen
in vitro construct
(Sevrioukov et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-dor.1-1002}
Cytology
Description

Full length dor (amino acids 1 to 1002) are expressed under the control of UAS regulatory sequences.

(Sevrioukov et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dor1-1002.Scer\UAS in border cells, driven by Scer\GAL4slbo.2.6, causes a border cell cluster migration defect in over 50-60% of egg chambers. However, the apical cap of these egg chambers forms and is shed normally.

      (Medioni and Noselli, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      dor1-1002.UAS/Scer\GAL4da.PU rescues dor35

      (Fernandes et al., 2014)

      dor1-1002.UAS/Scer\GAL4da.PU rescues dor36

      (Fernandes et al., 2014)

      Scer\GAL4FRT.Act5C/dor1-1002.UAS rescues dorC107

      (Chi et al., 2010)

      Scer\GAL4FRT.Act5C/dor1-1002.UAS rescues dorD185

      (Chi et al., 2010)

      Scer\GAL4FRT.Act5C/dor1-1002.UAS rescues dor8

      (Chi et al., 2010)

      dor1-1002.UAS/Scer\GAL4GMR.PF rescues dor1

      (Sevrioukov et al., 1999)

      dor1-1002.UAS/Scer\GAL4GMR.PF rescues dor4

      (Sevrioukov et al., 1999)
      Comments

      The increase in miniature excitatory junctional current amplitude and reduction in quantal content which is seen at the neuromuscular junction in dor35 and dor36 larvae is rescued by expression of dor1-1002.Scer\UAS under the control of Scer\GAL4da.PU. The reduction in synaptic vesicle recycling is at least partially rescued.

      Expression of dor1-1002.Scer\UAS under the control of Scer\GAL4VGlut.PU does not rescue the increase in miniature excitatory junctional current amplitude which is seen at the neuromuscular junction in dor35 and dor36 larvae, while the amplitude of the evoked excitatory junctional current is significantly increased compared to the single mutant larvae. The reduction in synaptic vesicle recycling is at least partially rescued.

      (Fernandes et al., 2014)

      Rescues the eye colour phenotype of dor1 or dor4 flies, when expressed under the control of Scer\GAL4GMR.PF.

      (Sevrioukov et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dor1-1002.Scer\UAS
      dor1-1002.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)