FlyBase Allele Report: Dmel\or[49h]

General Information

Symbol

Dmel\or^49h

Species

D. melanogaster

Name

FlyBase ID

FBal0013281

Feature type

allele

Associated gene

Dmel\or

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Cheli et al., 2010)

abnormal eye color | somatic clone

(Sevrioukov et al., 2005)

abnormal locomotor behavior

(Mullins et al., 2000)

visible | recessive

Phenotype Manifest In

photoreceptor cell pigment granule

(Mullins et al., 2000)

pigment cell

pigment cell | somatic clone

(Sevrioukov et al., 2005)

Detailed Description

Statement

Reference

Mutant flies have reduced red pigment in the eye compared to controls.

(Cheli et al., 2010)

Flies with eyes carrying or^49h clones show a reduction in pigment.

(Sevrioukov et al., 2005)

Examination of mutant eyes reveal a dramatic decrease in the number of electron dense pigment granules seen surrounding groups of photoreceptor cells. Examination of retinula cells from rb¹ mutants reveals normal neuronal anatomy, including normal cytoplasmic synaptic vesicles (SVs). In an assay for larval motility, or^49h mutants performed slightly less well than wild-type larvae. In locomotor assays testing olfactory response to propionic acid, or^49h mutants perform significantly less well than wild-type larvae.

(Mullins et al., 2000)

Eye colour: bright orange; like or¹. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

or^49h has abnormal eye color phenotype, enhanceable by aux^UAS.cHa/Scer\GAL4^GMR.PF

(Cheli et al., 2010)

or^49h has abnormal eye color phenotype, enhanceable by aux^{CJ.DPF.UAS.mRFP(Unk)}/Scer\GAL4^GMR.PF

(Cheli et al., 2010)

or^49h has abnormal eye color phenotype, enhanceable by aux^{FL.UAS.mRFP(Unk)}/Scer\GAL4^GMR.PF

(Cheli et al., 2010)

or^49h has abnormal eye color phenotype, enhanceable by aux^{CJ.UAS.mRFP(Unk)}/Scer\GAL4^GMR.PF

(Cheli et al., 2010)

NOT Enhanced by

Statement

Reference

or^49h has abnormal eye color phenotype, non-enhanceable by Scer\GAL4^GMR.PF/aux^{ΔC.UAS.mRFP(Unk)}

(Cheli et al., 2010)

or^49h has abnormal eye color phenotype, non-enhanceable by Scer\GAL4^GMR.PF/aux^{CJ.DLL.DPF.UAS.mRFP(Unk)}

(Cheli et al., 2010)

or^49h has abnormal eye color | somatic clone phenotype, non-enhanceable by Vps28^k16503

(Sevrioukov et al., 2005)

Enhancer of

Statement

Reference

or^49h is an enhancer of visible phenotype of p^p

(Falcon-Perez et al., 2007)

or^49h is an enhancer of abnormal eye color phenotype of p^p

(Falcon-Perez et al., 2007)

or^49h/or[+] is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

or^49h has pigment cell | somatic clone phenotype, non-enhanceable by Vps28^k16503

(Sevrioukov et al., 2005)

Enhancer of

Statement

Reference

or^49h is an enhancer of pigment cell phenotype of p^p

(Falcon-Perez et al., 2007)

or^49h/or[+] is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, bchs^EP2299

(Simonsen et al., 2007)

NOT Enhancer of

Statement

Reference

or^49h is a non-enhancer of ommatidium | somatic clone phenotype of Vps28^k16503

(Sevrioukov et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of aux^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PF enhances the loss of red eye pigment that is seen in or^49h flies.

(Cheli et al., 2010)

Expression of one of P{EPgy2}EY16920, CG9139^EP681a, PBac{WH}CG5342^f05247, P{EPgy2}EY00704, P{EPgy2}CG5903^EY11938 or CG17184^EY11874 under the control of Scer\GAL4^GMR.PF has no effect on the reduced red eye pigment phenotype of or^49h flies.

The loss of red eye pigment that is seen in or^49h flies is enhanced by expression of one of aux^{FL.Scer\UAS.T:Disc\RFP-mRFP}, aux^{CJ.Scer\UAS.T:Disc\RFP-mRFP} or aux^{CJ.DPF.Scer\UAS.T:Disc\RFP-mRFP} under the control of Scer\GAL4^GMR.PF.

Expression of aux^{ΔC.Scer\UAS.T:Disc\RFP-mRFP} or aux^{CJ.DLL.DPF.Scer\UAS.T:Disc\RFP-mRFP} under the control of Scer\GAL4^GMR.PF does not enhance the loss of red eye pigment that is seen in or^49h flies.

(Cheli et al., 2010)

Eye colour: or^49h; p^p eyes have significantly reduced levels of red pigment compared to either single mutant. The brown pigment levels are comparable to those seen in p^p single mutants.

(Falcon-Perez et al., 2007)

Eyes that carry Vps28^k16503, or^49h double mutant clones show the same two phenotypes as Vps28^k16503 and or^49h single mutant clones.

(Sevrioukov et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (12)

2385

5390

5373

5388

l(2)37Cb¹⁸ pr¹ or^49h/CyO

289

Adc^b-1 elA¹ PolD3^rd-s pr¹ cn¹ or^49h

Kyoto

108200

Phb1²³ or^49h/CyO

105902

sna^Sco Bl¹ or^49h/CyO

105837

Adc^b-1 elA¹ PolD3^rd-s pr¹ cn¹ or^49h

101393

CyO, Duox^Cy dpy^lv1 pr¹ cn² / Lim3⁴ or^49h

101352

CyO, Duox^Cy dpy^lv1 pr¹ cn² / brat^fs1 or^49h

101391

CyO, Duox^Cy dpy^lv1 pr¹ cn² / l(2)37Bb⁹ or^49h

101379

CyO, Duox^Cy dpy^lv1 pr¹ cn² / Ddc²⁷ brat¹⁸ pr¹ or^49h

Notes on Origin

Discoverer

Ives, 31st Aug. 1949.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

or^49h2

(Sevrioukov et al., 2005)

or^49h

(Wang et al., 2012, Cheli et al., 2010, Cheli et al., 2010, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Falcon-Perez et al., 2007)

orange_49h

(Yuva-Aydemir et al., 2011)

orange⁴⁹

(Bartlett et al., 2011)

orange^49h

(Simonsen et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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