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General Information
Symbol
Dmel\pp
Species
D. melanogaster
Name
peach
FlyBase ID
FBal0013456
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

The deletion of a single base (A) in codon Q648 causes a frameshift and early translation termination 39 aa downstream.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotides 1946-1948 (ATG), part of codons 649-650 of wild-type p are substituted by TT, resulting in a frameshift. The mutated gene encodes residues 1-648 of p, followed by an unrelated segment of 39 amino acids and an early termination codon.

Single base pair deletion within codon Q648, resulting in a frameshift. The resulting truncated protein is predicated to contain 648 amino acids from wild-type p followed by 39 additional amino acids. Also contains a silent base change in the P62 codon and a nucleotide change in the p upstream region (POU sequence CAAAT is changed to CCAAT).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant flies have reduced red pigment in the eye compared to controls.

Eye colour: abnormal with reduced levels of red and brown pigment (20 and 15% of wild-type levels respectively).

Homozygous and pp/Df(3R)p25 flies show a reduction in pteridine (red) eye pigment levels compared to controls.

pp males that are also mutant for mle4 show darker eye pigmentation with respect their mle4/+ sibs.

Eye colour: dull ruby.

9% normal red and 15% normal brown pigment.

Color autonomous in pp optic disk allowed to undergo metamorphosis in a wild-type host.

Eye colour: lighter and more orange than p1.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

pp has visible phenotype, enhanceable by g2

pp has abnormal eye color phenotype, enhanceable by g2

pp has visible phenotype, enhanceable by or49h

pp has abnormal eye color phenotype, enhanceable by or49h

pp has visible phenotype, enhanceable by Rab321

pp has abnormal eye color phenotype, enhanceable by Rab321

NOT Enhanced by
Statement
Reference

pp has abnormal eye color phenotype, non-enhanceable by Blos1ex2

NOT suppressed by
Statement
Reference

pp has abnormal eye color phenotype, non-suppressible by Blos1ex2

Phenotype Manifest In
Enhanced by
Statement
Reference

pp has pigment cell phenotype, enhanceable by g2

pp has pigment cell phenotype, enhanceable by or49h

NOT suppressed by
Statement
Reference

pp has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference

The reduced red eye pigment phenotype of pp blos1ex2 double mutants is indistinguishable from that of pp single mutants.

Eye colour: g2; pp eyes are lighter and have significantly reduced levels of red pigment compared to either single mutant. The brown pigment levels are comparable to those seen in pp single mutants. or49h; pp double mutants also have reduced levels of red pigment but similar levels of brown pigment to pp single mutants.

Eye colour: car1; pp eyes are lighter than either single mutant. The levels of red pigment in the double mutants is comparable to that in car1 single mutant eyes and the level of brown pigment is comparable to pp single mutant eyes.

Eye colour: ltd1; pp eyes are relatively lighter than those of either single mutants.

Eye colour: brownish, with pp/+, wbf/+. Eye colour: brownish, with pp/+, wh/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (2)
Stocks (398)
Notes on Origin
Discoverer

Bridges, 24th Jan. 1913.

Comments
Comments

The p1, pp and psnb alleles have been found to have identical changes in sequence, despite being reported to have arisen independently. It seems more likely that stock contamination, mislabelling, or loss occurred some time during past handling of stocks, rather than the same lesions having occurred independently three times.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (27)