FlyBase Gene Report: Dmel\poe

General Information

Symbol

Dmel\poe

Species

D. melanogaster

Name

purity of essence

Annotation Symbol

CG14472

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011230

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

purity of essence (poe) encodes a Calmodulin-binding, E3 ubiquitin ligase. It functions in glial growth in peripheral nerves, motor neuron excitability, synaptic vesicle release and sperm individuation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

push, pushover, Calossin, Calo, Ubr4

Key Links

Genomic Location

Cytogenetic map

28D11-28E1

Sequence location

2L:8,054,322..8,071,624 [-]

Recombination map

2-30

RefSeq locus

NT_033779 REGION:8054322..8071624

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables calmodulin binding

inferred from direct assay

(Xu et al., 1998)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ubiquitin protein ligase activity

inferred from sequence or structural similarity with UniProtKB:Q5T4S7

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000497103

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR003126

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in glial cell growth

inferred from mutant phenotype

(Yager et al., 2001)

involved_in negative regulation of ERK1 and ERK2 cascade

inferred from genetic interaction with FLYBASE:Usp47; FB:FBgn0016756

(Ashton-Beaucage et al., 2016)

involved_in perineurial glial growth

inferred from mutant phenotype

(Yager et al., 2001)

inferred from genetic interaction with FLYBASE:eag; FB:FBgn0000535

(Yager et al., 2001)

inferred from genetic interaction with FLYBASE:ine; FB:FBgn0011603

(Yager et al., 2001)

inferred from genetic interaction with FLYBASE:Nf1; FB:FBgn0015269

(Yager et al., 2001)

involved_in positive regulation of male gonad development

inferred from mutant phenotype

(Xie et al., 2023)

involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process

inferred from mutant phenotype

(Ashton-Beaucage et al., 2016)

involved_in sperm individualization

inferred from mutant phenotype

(Arama et al., 2003, Fabrizio et al., 1998)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasm protein quality control

inferred from biological aspect of ancestor with PANTHER:PTN000497103

(GO Reference Genome Project, 2011-)

involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway

inferred from biological aspect of ancestor with PANTHER:PTN000497103

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in P granule

inferred from physical interaction with FLYBASE:tud; FB:FBgn0003891

(Thomson et al., 2008)

inferred from physical interaction with FLYBASE:vas; FB:FBgn0283442

(Thomson et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000497103

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED E3 UBIQUITIN LIGASES

Protein Family (UniProt)

Belongs to the UBR4 family. (Q9VLT5)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED E3 UBIQUITIN LIGASES -: This group comprises E3 ubiquitin ligases that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Has a role in growth of the perineurial glial layer of the larval peripheral nerve (PubMed:27552662). May have a role in male fertility and eye development or function (PubMed:27552662). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662).

(UniProt, Q9VLT5)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\poe for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VLT5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

poe-RA

FBtr0079545

NM_057638

16216

5322

poe-RB

FBtr0333088

NM_001273293

16158

5322

Additional Transcript Data and Comments

Reported size (kB)

15-20 (northern blot)

(Xu et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

poe-PA

FBpp0079167

590.7

5322

6.34

FBpp0305301

590.7

5322

6.34

Q9VLT5

NP_001260222

AGB92758

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

5322 aa isoforms: poe-PA, poe-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

4118 (aa)

(Xu et al., 1998)

Comments

External Data

Subunit Structure (UniProtKB)

May bind calmodulin (PubMed:9813038). Interacts with Kcmf1 (PubMed:27552662).

(UniProt, Q9VLT5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\poe using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

poe_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.02

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

(Xu et al., 1998)

Additional Descriptive Data

poe transcripts are expressed at high levels in adult flies, and at very low levels in other developmental stages.

(Xu et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in P granule

inferred from physical interaction with FLYBASE:tud; FB:FBgn0003891

(Thomson et al., 2008)

inferred from physical interaction with FLYBASE:vas; FB:FBgn0283442

(Thomson et al., 2008)

Expression Deduced from Reporters

Reporter: P{PZ}poe⁰¹⁶⁵⁹

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

imaginal disc

(Meister and Braun, 1995.10)

larval brain

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\poe in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\poe

View exonic expression by tissue for Dmel\poe

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46243/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011230

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011230

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011230

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14472

Flygut - An atlas of the Drosophila adult midgut

FBgn0011230

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of poe

Transgenic constructs containing regulatory region of poe

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene not disrupted in

Df(2L)J-H

(BDGP Project Members, 1994-1999)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

poe^GD8339

viable, with Scer\GAL4^Mef2.PR

poe^GD8339

viable, with Scer\GAL4^pnr-MD237

poe^GD8339

viable, with Scer\GAL4^tin.CΔ4

poe^GD8339

viable | adult stage

poe⁵⁹⁷⁰

Sterility

Allele

female fertile

male sterile

male sterile | recessive

Other Phenotypes

Allele

abnormal behavior

abnormal body color, with Scer\GAL4^pnr-MD237

poe^GD8339

abnormal meiotic cell cycle

poe^P21

abnormal neuroanatomy

poe⁰¹⁶⁵⁹

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

poe^EP737

abnormal neurophysiology | larval stage

uncoordinated

Phenotype manifest in

Allele

anterior fascicle & synapse, with Scer\GAL4^elav-C155

poe^EP737

bouton

poe⁰¹⁶⁵⁹

CNS surface glial cell

poe¹

cystic bulge

poe¹

larval intersegmental nerve, with Scer\GAL4^elav-C155

poe^EP737

mesonotum, with Scer\GAL4^pnr-MD237

poe^GD8339

primary spermatocyte cyst

poe⁵⁹⁷⁰

spermatozoon

poe⁵⁹⁷⁰

synapse

poe⁰¹⁶⁵⁹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\UBR4

14 of 14

Yes

Hsap\UBR5

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Ubr4

13 of 14

Yes

Rnor\Ubr5

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Ubr4

13 of 14

Yes

Mmus\Ubr5

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\ubr4

8 of 13

Yes

Xtro\borcs6

1 of 13

Xtro\marchf8

1 of 13

Xtro\ubr5

1 of 13

Danio rerio (Zebrafish) (2)

Drer\ubr4

12 of 14

Yes

Drer\ubr5

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\ubr-4

10 of 14

Yes

Cele\ubr-5

1 of 14

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP001157

12 of 12

Yes

Agam\AgaP_AGAP001780

1 of 12

Arabidopsis thaliana (thale-cress) (2)

Atha\BIG

12 of 13

Yes

Atha\MPC

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:poe. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

hyd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

poe^HMS00739

model of intellectual disability

CEA

(Haddadi and Ataei, 2022)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

poe^HMS00739

ameliorates neurodegenerative disease

modeled by Zzzz\CAG^{63Q.GMR.Tag:HA}

(Xie et al., 2021)

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Xie et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UBR4; ubiquitin protein ligase E3 component n-recognin 4

14 of 14

609890

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

poe - CG15286

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

poe - Cam

lambda phage display

(Xu et al., 1998)

poe - Kcmf1

anti tag coimmunoprecipitation, anti tag western blot

(Ashton-Beaucage et al., 2016)

poe - Lkb1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

poe - Plp

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Galletta et al., 2023)

poe - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

poe - Rack1

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2021)

poe - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

poe - rictor

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

poe - rl

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2021)

poe - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

poe

enhanceable

ine

(Yager et al., 2001)

poe

enhanceable

Nf1

(Yager et al., 2001)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cdc42

suppressible

poe

(Raymond et al., 2004)

cindr

enhanceable

poe

(Ketosugbo et al., 2017)

Nf1

enhanceable

poe

(Yager et al., 2001)

Rac1

suppressible

poe

(Raymond et al., 2004)

RacGAP84C

suppressible

poe

(Raymond et al., 2004)

Usp47|rl

enhanceable

poe

(Ashton-Beaucage et al., 2016)

External Data

Subunit Structure (UniProtKB)

May bind calmodulin (PubMed:9813038). Interacts with Kcmf1 (PubMed:27552662).

(UniProt, Q9VLT5 )

Linkouts

BioGRID - A database of protein and genetic interactions.

70146

DroID - A comprehensive database of gene and protein interactions.

FBgn0011230

MIST (protein-protein) - An integrated Molecular Interaction Database

46243

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-30

Cytogenetic map

28D11-28E1

Sequence location

2L:8,054,322..8,071,624 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

28D11-28E1

Limits computationally determined from genome sequence between P{lacW}l(2)k10210^k10210 and P{EP}poe^EP737

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

28E1-28E1

(Richards, 1998.10.6)

28E1-28E2

(Montell, 1998.8.11)

28E1-28E9

(determined by in situ hybridisation)

(Spradling et al., 1999)

28E-28E

(determined by in situ hybridisation)

(Sekelsky et al., 1999, Fabrizio et al., 1998, Riesgo-Escovar et al., 1992)

28E1-28E2

(determined by in situ hybridisation)

(Xu et al., 1998)

28D-28E

(determined by in situ hybridisation)

(Richards et al., 1996)

28D-28E

(Soehnge et al., 1995)

27C1-27C9

28E1--9

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-30

(FlyBase, 2016)

2-26.4

(Comeron et al., 2012)

2-27

(Richards et al., 1996)

(Soehnge et al., 1995)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85077

w¹¹¹⁸; PBac{PB}poe^c07064/CyO

85536

w¹¹¹⁸; PBac{RB}poe^e00753/CyO

11761

P{PZ}poe⁰³⁴²⁰ cn¹/CyO; ry⁵⁰⁶

91498

y¹ w^*; TI{CRIMIC.TG4.2}poe^{CR02270-TG4.2}/SM6a

32945

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00739}attP2

Kyoto

105343

y^* w^*; P{GawB}poe^NP7039 / CyO, P{UAS-lacZ.UW14}UW14

NIG-Fly

14472R-1

P{NIG.14472R}1

14472R-3

P{NIG.14472R}3

HMS00739

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00739}attP2

2LG-1466

y² VhaAC39-1^cho-1 v¹; P{U6-poe.NIG.sgRNA.1}attP40/CyO

VDRC

v108296

P{KK101471}VIE-260B

v17648

w¹¹¹⁸; P{GD8339}v17648

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (49)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP02909

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011230

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011230

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Greenblatt and Spradling, 2018)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: Cam-binding protein that is expressed in the retina.

(Xu et al., 1998)

The poe gene might affect both neuronal excitability and the transmitter release process.

(Richards et al., 1996)

Postmeiotic differentiation defect.

(Castrillon et al., 1993)

Relationship to Other Genes

Source for database merge of

Source for merge of: poe push

(Timakov, 1999.4.23)

Source for merge of: poe Calo CG14472

(Bayraktaroglu, 2000.4.12)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named "pushover" as mutant flies when pushed onto their dorsal surface by mechanical agitation require an average of 46 seconds to right themselves, 20-fold more time than required for wild type.

(Richards et al., 1996)

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

3420

(Soehnge et al., 1995)

CG14472

(National Institute of Genetics Fly Stocks, 2022-, Kolkhof et al., 2017, Çiçek et al., 2016, Christis and Munro, 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ditzel et al., 2008, Kraut et al., 2001, Kraut et al., 2001)

Calo

(Anholt and Mackay, 2001, Xu et al., 1998)

POE

(Ashton-Beaucage et al., 2016, Thomson et al., 2008)

POE/UBR4

(Ashton-Beaucage et al., 2016)

POE_DROME

(Fukuyama et al., 2012)

Poe

(Flanagan et al., 2022, Sheng and Du, 2020, Lindquist et al., 2011)

UBR4

(Hunt et al., 2019, Ashton-Beaucage et al., 2016)

Ubr4

(Xie et al., 2023, Hegazi et al., 2022, Sheng and Du, 2020)

calo

(Montell, 1998.8.11)

dUBR4

(François et al., 2023)

ms(2)01659

ms(2)27C

ms(2)3420

ms(2)5970

(Fabrizio et al., 1998)

push

(Yager et al., 2001, Yager et al., 2001, Yager et al., 2000, Sekelsky et al., 1999, Richards, 1998.10.6, Richards, 1998.10.6)

Name Synonyms

Calossin

(Kraut et al., 2001, Xu et al., 1998)

Purity of Essence

(Thomson et al., 2008)

male sterile(2)27C

male sterile(2)3420

purity of essence

(Rees et al., 2011, Wasbrough et al., 2010, Blard et al., 2007, Rathke et al., 2007, Raymond et al., 2004)

pushover

(Hashimoto et al., 2002, Kraut et al., 2001, Kraut et al., 2001, Yager et al., 2001, Yager et al., 2000)

Secondary FlyBase IDs

FBgn0010161
FBgn0011240
FBgn0015532
FBgn0025867
FBgn0031982

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

46243

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VLT5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VLT5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PB68

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VLT5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

46243/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011230

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011230

FlyMine - An integrated database for Drosophila genomics

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InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14472

MARRVEL_MODEL - MARRVEL (model organism gene)

46243

Linkouts

BioGRID - A database of protein and genetic interactions.

70146

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

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DroID - A comprehensive database of gene and protein interactions.

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DRSC - Results frm RNAi screens

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Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

poe_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

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FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011230

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14472

Flygut - An atlas of the Drosophila adult midgut

FBgn0011230

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011230

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004400

MIST (protein-protein) - An integrated Molecular Interaction Database

46243

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (112)

The following external sites may use different assemblies or annotations than FlyBase.

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