FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cdc425
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General Information
Symbol
Dmel\Cdc425
Species
D. melanogaster
Name
FlyBase ID
FBal0062062
Feature type
allele
Associated gene
Dmel\Cdc42
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Baron et al., 2000)
Mutagen
ethyl methanesulfonate
(Fehon et al., 1997)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G214A. Amino acid replacement: D65N.

(Genova et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,698,150..19,698,150 [+]
Nucleotide change:

G19698150A

Reported nucleotide change:

G214A

Amino acid change:

D65N | Cdc42-PA; D65N | Cdc42-PC; D65N | Cdc42-PD

Reported amino acid change:

D65N

(Genova et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AF153428
AAD43792
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eyes of hemizygous male flies show planar polarity phenotypes (misrotated or achiral ommatidia), although at a very low frequency.

      Homozygous clones in the eye show planar polarity defects, with 2.9% of ommatidia being abnormal.

      (Muñoz-Descalzo et al., 2007)

      Cdc421/Cdc425 mutant eyes display disruptions in the normal ommatidial pattern, ommatidial fusion, and loss of bristles in the dorsal posterior quadrant. All photoreceptor cells are present within the ommatidia and in the proper orientation. Cdc421/Cdc425 mutant wings often have extra anterior crossveins.

      (Genova et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Cdc425 is an enhancer of abnormal planar polarity | somatic clone phenotype of MtlΔ, Rac1J11, Rac2Δ

      (Muñoz-Descalzo et al., 2007)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Cdc425 is an enhancer of ommatidium | somatic clone phenotype of MtlΔ, Rac1J11, Rac2Δ

      (Muñoz-Descalzo et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Rac1J11, Rac2Δ, MtlΔ triple mutant clones in the eye result in a low frequency (approximately 5%) of planar polarity defects (such as achiral or misrotated ommatidia). Cdc425, Rac1J11, Rac2Δ, MtlΔ quadruple mutant clones in the eye result in a higher frequency of (14.2%) of planar polarity defects.

      (Muñoz-Descalzo et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 2 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cdc425
      (Dollar et al., 2016, Muñoz-Descalzo et al., 2007)
      Dcdc425
      (Baron et al., 2000)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)