FlyBase Allele Report: Dmel\Cdc42[KK108698]

General Information

Symbol

Dmel\Cdc42^KK108698

Species

D. melanogaster

Name

FlyBase ID

FBal0235750

Feature type

allele

Associated gene

Dmel\Cdc42

Associated Insertion(s)

Carried in Construct

P{KK108698}

Also Known As

cdc42 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108698}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108698

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^C57

(Nahm et al., 2010)

Phenotype Manifest In

bouton, with Scer\GAL4^C57

(Nahm et al., 2010)

epithelium, with Scer\GAL4^NP1624

(Berns et al., 2014)

female germline cyst, with Scer\GAL4^NP1624

(Berns et al., 2014)

neuromuscular junction, with Scer\GAL4^C57

(Nahm et al., 2010)

Detailed Description

Statement

Reference

Scer\GAL4^tj-NP1624-mediated expression abolishes cyst encapsulation and results in germline cysts completely lacking an epithelium. Affected ovarioles look like tubes in which naked cysts pile up.

(Berns et al., 2014)

Expression of Cdc42^KK108698 post-synaptically under the control of Scer\GAL4^C57 results in an increase in synaptic growth.

Expression of Cdc42^KK108698 in neurons under the control of Scer\GAL4^elav-C155 increases the overall synaptic bouton, satellite bouton number and total neuromuscular junction length.

(Nahm et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cdc42^KK108698/Scer\GAL4^Mhc.PU is a suppressor of abnormal neurophysiology | third instar larval stage phenotype of Dyb¹¹

(Jantrapirom et al., 2019)

Other

Statement

Reference

Cdc42^KK108698, Dyb¹¹, Scer\GAL4^Mhc.PU has abnormal neurophysiology | third instar larval stage phenotype

(Jantrapirom et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cdc42^KK108698/Scer\GAL4^Mhc.PU is a suppressor of A1-7 ventral longitudinal muscle cell | larval stage phenotype of Dyb¹¹

(Jantrapirom et al., 2019)

Other

Statement

Reference

Cdc42^KK108698, Dyb¹¹, Scer\GAL4^Mhc.PU has A1-7 ventral longitudinal muscle cell | larval stage phenotype

(Jantrapirom et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Cdc42^KK108698 under the control of Scer\GAL4^Mhc.PU suppresses the quantal content and evoked junctional potential phenotypes of Dyb¹¹ heterozygotes.

Expression of Cdc42^KK108698 under the control of Scer\GAL4^Mhc.PU leads to a significant increase in the frequency of miniature evoked junctional potentials in Dyb¹¹ heterozygous third instar larval muscle 6 compared to controls.

(Jantrapirom et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v100794

P{KK108698}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cdc42^KK108698

cdc42^IR

(Nunes de Almeida et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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