FlyBase Allele Report: Dmel\Cdc42[GL00620]

General Information

Symbol

Dmel\Cdc42^GL00620

Species

D. melanogaster

Name

FlyBase ID

FBal0266319

Feature type

allele

Associated gene

Dmel\Cdc42

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00620}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00620}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00620

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage, with Scer\GAL4^lz.PU

(Gazsó-Gerhát et al., 2023)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

ommatidium | P-stage, with Scer\GAL4^lz.PU

(Gazsó-Gerhát et al., 2023)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in misshapen and rough eye phenotype.

(Pletcher et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^Mz19 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

NOT Enhancer of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

NOT Suppressor of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Cdc42^GL00620, Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, egr^UAS.cMa

(Ruan et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^Mz19 is an enhancer of adult antennal lobe phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Cdc42^GL00620, Scer\GAL4^Mz19 is an enhancer of neuron projection | adult stage phenotype of Scer\GAL4^Mz19, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

NOT Enhancer of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-enhancer of neuron projection | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-enhancer of adult antennal lobe phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

NOT Suppressor of

Statement

Reference

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-suppressor of neuron projection | adult stage phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Cdc42^GL00620, Scer\GAL4^DBD.R22E04, Hsap\RELA^AD.VT028327 is a non-suppressor of adult antennal lobe phenotype of Hsap\RELA^AD.VT028327, Scer\GAL4^DBD.R22E04, Ten-m^UAS.Tag:V5

(Xu et al., 2024)

Cdc42^GL00620, Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, egr^UAS.cMa

(Ruan et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The dot-like small eye phenotype characteristic for flies expressing egr^Scer\UAS.cMa under the control of Scer\GAL4^GMR.PFa cannot be suppressed by co-expression of Cdc42^GL00620 RNAi.

(Ruan et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37477

y¹ sc^* v¹ sev²¹; P{TRiP.GL00620}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cdc42^GL00620

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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