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Citation
Gao, F.B., Brenman, J.E., Jan, L.Y., Jan, Y.N. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila.  Genes Dev. 13(19): 2549--2561.
FlyBase ID
FBrf0111874
Publication Type
Research paper
Abstract

Signaling between neurons requires highly specialized subcellular structures, including dendrites and axons. Dendrites exhibit diverse morphologies yet little is known about the mechanisms controlling dendrite formation in vivo. We have developed methods to visualize the stereotyped dendritic morphogenesis in living Drosophila embryos. Dendrite development is altered in prospero mutants and in transgenic embryos expressing a constitutively active form of the small GTPase cdc42. From a genetic screen, we have identified several genes that control different aspects of dendrite development including dendritic outgrowth, branching, and routing. These genes include kakapo, a large cytoskeletal protein related to plectin and dystrophin; flamingo, a seven-transmembrane protein containing cadherin-like repeats; enabled, a substrate of the tyrosine kinase Abl; and nine potentially novel loci. These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis.

PubMed ID
PubMed Central ID
PMC317067 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
Gao et al., 1999, Genes Dev. 13(23): 3170 [FBrf0125044]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference