FlyBase Allele Report: Dmel\ena[02029]

General Information

Symbol

Dmel\ena⁰²⁰²⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0007989

Feature type

allele

Associated gene

Dmel\ena

Associated Insertion(s)

P{PZ}ena⁰²⁰²⁹

Carried in Construct

Also Known As

l(2)02029

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gao et al., 1999, Spradling et al., 1999, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}ena⁰²⁰²⁹

Cytology

Description

P{PZ} in the 5' region of the ena gene.

(Gao et al., 1999)

The P{PZ}ena⁰²⁰²⁹ insertion maps within both ena and CG15118 (overlapping genes on opposite strands).

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:19,142,331..19,142,338 [+]

(Matusek et al., 2008, Gao et al., 1999, Spradling et al., 1999, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spradling et al., 1999)

partially lethal - majority die

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ena⁰²⁰²⁹/ena[+] is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex68

(Matusek et al., 2008)

NOT Suppressor of

Statement

Reference

ena⁰²⁰²⁹/ena[+] is a non-suppressor of abnormal neuroanatomy phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

Other

Statement

Reference

Df(2R)en-SFX31, ena⁰²⁰²⁹ has abnormal neuroanatomy phenotype

(Joly et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

ena⁰²⁰²⁹/ena[+] is an enhancer of neuropil phenotype of DAAM^Ex68

(Matusek et al., 2008)

ena⁰²⁰²⁹/ena[+] is an enhancer of fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

ena⁰²⁰²⁹/ena[+] is an enhancer of connective phenotype of DAAM^Ex68

(Matusek et al., 2008)

ena⁰²⁰²⁹/ena[+] is an enhancer of lateral longitudinal fascicle phenotype of DAAM^Ex68

(Matusek et al., 2008)

ena⁰²⁰²⁹/ena[+] is an enhancer of embryo phenotype of DAAM^Ex68

(Matusek et al., 2008)

NOT Suppressor of

Statement

Reference

ena⁰²⁰²⁹/ena[+] is a non-suppressor of ventral adult lateral neuron & axon phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

Other

Statement

Reference

Df(2R)en-SFX31, ena⁰²⁰²⁹ has larval ventral nerve cord phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, ena⁰²⁰²⁹ has larval anterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, ena⁰²⁰²⁹ has larval posterior commissure phenotype

(Joly et al., 2007)

Df(2R)en-SFX31, ena⁰²⁰²⁹ has lateral tract phenotype

(Joly et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

An ena⁰²⁰²⁹ heterozygous background increases the proportion of DAAM^Ex68 mutant embryos that exhibit CNS defects.

(Matusek et al., 2008)

Stage 15 transheterozygous Df(2R)en-SFX31/ena⁰²⁰²⁹ embryos exhibit defects in central nervous system scaffolding with gaps in longitudinal tracts, loss of posterior commissures, or fusion of commissures in about 74.5% of the segments.

(Joly et al., 2007)

S^48-5/ena⁰²⁰²⁹ mutants show 7.77%+-2.95 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

Xenogenetic Interactions

Statement

Reference

Heterozygosity for ena⁰²⁰²⁹ does not interfere with the Scer\GAL4^P2.4.Pdf>Hsap\APP^{Scer\UAS.T:Hsap\MYC}-induced increase in sLNv axonal arborization.

(Leyssen et al., 2005)

Complementation and Rescue Data

Fails to complement

ena⁴⁶

(Gao et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11114

cn¹ P{PZ}ena⁰²⁰²⁹ CG15118⁰²⁰²⁹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: hts⁰⁰⁶³⁴. Complements: cora^k08713.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Ena⁰²⁰²⁹

(Leyssen et al., 2005)

ena-02029

(Gaengel and Mlodzik, 2003)

ena⁰²⁰²⁹

(Matusek et al., 2008, Joly et al., 2007)

enb⁰²⁰²⁹

l(2)02029

(Gao et al., 1999, Spradling et al., 1999)

l(2)02029⁰²⁰²⁹

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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