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General Information
Symbol
Dmel\enaGC8
Species
D. melanogaster
Name
FlyBase ID
FBal0043045
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

enaGC5/enaGC8 embryos show modest levels of midline crossing errors by axons in the central nervous system.

29% of ISNb axons show a bypass phenotype in enaGC5/enaGC8 embryos. A small number of RP neurons follow an aberrant path within the central nervous system. 7% of ISNb axons show a bypass phenotype in enaGC8/+ embryos.

Heterozygotes with enaGC1 have diffuse and loosely bundled longitudinal and commissural axon tracts. Some heterozygotes with enaGC5 also exhibit axon misguiding. Some homozygous embryos exhibit thinning of longitudinal connectives, increased number of axons exciting the CNS from the longitudinal axons or failure of commissural axons to separate into anterior and posterior axon bundles. The overall organisation of the PNS is disrupted, spacing and organisation of the neurons is irregular and some clusters of neurons are mislocalised.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

robo[+], ena[+], enaGC8, robo15 is an enhancer of larval longitudinal connective phenotype of sli1

ena[+]/enaGC8 is an enhancer of larval longitudinal connective phenotype of robo15, sli[+]/sli1

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
enaGC8
enbGC8
Name Synonyms
Secondary FlyBase IDs
    References (8)