FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.
Embryos mutant for loss of function mutations show axon guidance defects in ISNb, SNa and the CNS. The majority of defects are manifest as a decrease in repulsion.
Mutants exhibit an axon guidance phenotype. The SNa branches abnormally, and the ISNb nerve also sometimes branches abnormally.
No gross dentritic defects are seen in mutant embryos.
The SNa nerve shows abnormal branching in 67% of segments in homozygous embryos. The ISNb branch of the intersegmental nerve often shows abnormal innervation of muscles 6, 7, 12 and 13. The outermost Fas2-positive longitudinal connective is often disrupted.
Sema1aunspecified has larval intersegmental nerve phenotype, enhanceable by otk3
Sema1aunspecified has larval abdominal segmental nerve phenotype, enhanceable by otk3
Sema1aunspecified is an enhancer of larval intersegmental nerve phenotype of otk3
Sema1aunspecified is an enhancer of larval abdominal segmental nerve phenotype of otk3
Df(4)C3/+, Sema1aunspecified has larval longitudinal connective phenotype
Df(4)C3/+, Sema1aunspecified has larval intersegmental nerve phenotype
Df(4)C3/+, Sema1aunspecified has larval abdominal segmental nerve phenotype
The addition of otk3/+ enhances the SNa and ISNb axon guidance phenotypes seen in Sema-1aunspecified/+ flies.
Sema-1aunspecified Df(4)C3 double heterozygotes show abnormal innervation of ventral muscles by the ISNb branch of the intersegmental nerve in most segments. The SNa nerve shows abnormal branching in 72.1% of segments in these embryos and the outermost Fas2-positive longitudinal connective is disrupted in 20.5% of segments. beat-Iaunspecified does not show dominant interactions with Sema-1aunspecified.
