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Citation
Sterne, G.R., Kim, J.H., Ye, B. (2015). Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors.  eLife 4(): e05196.
FlyBase ID
FBrf0228582
Publication Type
Research paper
Abstract

Increased expression of Down Syndrome Cell Adhesion Molecule (Dscam) is implicated in the pathogenesis of brain disorders such as Down syndrome (DS) and fragile X syndrome (FXS). Here, we show that the cellular defects caused by dysregulated Dscam levels can be ameliorated by genetic and pharmacological inhibition of Abelson kinase (Abl) both in Dscam-overexpressing neurons and in a Drosophila model of fragile X syndrome. This study offers Abl as a potential therapeutic target for treating brain disorders associated with dysregulated Dscam expression.

PubMed ID
PubMed Central ID
PMC4434255 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (12)
    Genes (9)
    Human Disease Models (4)
    Physical Interactions (1)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (6)
    Transgenic Constructs (8)