FlyBase Allele Report: Dmel\Abl::Hsap\ABL1::Hsap\BCR[P210.UAS]

General Information

Symbol

Dmel\Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0095897

Feature type

allele

Associated gene

Abl::Hsap\ABL1::Hsap\BCR

Associated Insertion(s)

Carried in Construct

P{UAS-P210}

Also Known As

UAS-Bcr-Abl, U-BcrAbl

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Fogerty et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-P210}

Cytology

Description

UASt regulatory sequences drive expression of a chimeric construct consisting of Hsap\BCR exons 1 to 3 (encoding 927 amino acids), Hsap\ABL1 exon 2 and the first 204 codons of Hsap\ABL1 exon 3 and Abl sequence from codon 47 to the C-terminal end of the Abl protein.

(Fogerty et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Abl::Hsap\ABL1::Hsap\BCR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of chronic myeloid leukemia

CEA

(Fogerty et al., 1999)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

commissure | ectopic, with Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

commissure | embryonic stage 16, with Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^{elav.Switch.PO}

(Kim et al., 2024)

eye, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

eye photoreceptor cell, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

interommatidial bristle, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

larval longitudinal connective, with Scer\GAL4³¹

(Fogerty et al., 1999)

larval longitudinal connective | embryonic stage 16, with Scer\GAL4^elav.PLu

(Hsouna et al., 2003)

larval longitudinal connective | embryonic stage 16, with Scer\GAL4^ftz.ng

(Hsouna et al., 2003)

larval multidendritic class IV neuron | third instar larval stage, with Scer\GAL4^ppk.PG

(Sterne et al., 2015)

larval ventral nerve cord commissure, with Scer\GAL4³¹

(Fogerty et al., 1999)

larval ventral nerve cord commissure, with Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

larval ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

lens, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

macropinosome | increased number | larval stage, with Scer\GAL4^{elav.Switch.PO}

(Kim et al., 2024)

ommatidium, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

presumptive embryonic/larval central nervous system, with Scer\GAL4³¹

(Fogerty et al., 1999)

rhabdomere, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

secondary pigment cell, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

tertiary pigment cell, with Scer\GAL4^hs.2sev

(Fogerty et al., 1999)

ventral adult lateral neuron & axon, with Scer\GAL4^P2.4.Pdf

(Leyssen et al., 2005)

Detailed Description

Statement

Reference

Ectopic expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^ppk.PG causes a robust presynaptic terminal overgrowth and significantly increases the number of connectives in class IV dendritic arborizing neurons in third instar larvae compared to controls.

(Sterne et al., 2015)

Expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} in embryos results in fuzzy commissures, a defect caused by extra axons crossing the midline.

Pan-neural expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^insc-Mz1407 causes multiple Fas2-positive axon bundles to ectopically cross the midline in most segments of nearly all embryos examined.

(Dorsten et al., 2010)

Stage 16 embryos expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} driven by Scer\GAL4^ftz.ng display axon bundles that cross the midline inappropriately.

(Dorsten et al., 2007)

Expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, under the control of Scer\GAL4^P2.4.Pdf, causes a strong increase in axonal extension and arborization of the sLNv.

(Leyssen et al., 2005)

Limiting expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} to primarily pCC/MP2 neurons using Scer\GAL4^ftz.ng is sufficient to induce on average three to four Fas2-positive axons to cross the midline incorrectly in all embryos examined.

Pan-neural expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} using Scer\GAL4^elav.PLu results in axonal midline-crossing abnormalities.

(Hsouna et al., 2003)

Embryos expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4³¹ have defects in the central nervous system (CNS); the longitudinal and commissural axons are less tightly bundled than normal and increased numbers of axons exit the CNS from the longitudinal tracts. Flies expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^hs.2sev are viable and fertile and have a severe rough eye phenotype; the eyes are small and bar-shaped with a large reduction in the number of ommatidial facets. The facets are abnormally shaped and vary in size. Multiple misplaced mechanosensory bristles and lens defects are seen. The ommatidia lack one or more retinal cells and/or have elongated or fused rhabdomeres or retinal cells. The secondary and tertiary pigment cells are disorganised.

(Fogerty et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has abnormal neuroanatomy | embryonic stage 16 phenotype, enhanceable by fra^UAS.cKa, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has abnormal neuroanatomy | embryonic stage 16 phenotype, enhanceable by fra^ΔP1.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has abnormal neuroanatomy | embryonic stage 16 phenotype, enhanceable by fra^ΔP2.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

NOT Enhanced by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by fra³/fra[+]

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by fra³/fra⁴/fra^UAS.cKa, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by fra^ΔP1.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-enhanceable by fra³/fra⁴/fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has abnormal neuroanatomy | embryonic stage 16 phenotype, non-enhanceable by fra^ΔP3.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Suppressed by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, suppressible | partially by fra^ΔP3.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, suppressible by fra³/fra⁴

(Dorsten et al., 2010)

NOT suppressed by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra³/fra[+]

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra³/fra⁴/fra^UAS.cKa, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra^ΔP1.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has abnormal neuroanatomy | embryonic stage phenotype, non-suppressible by fra³/fra⁴/fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of fra³/fra⁴

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS/Scer\GAL4^ftz.ng is an enhancer of abnormal neuroanatomy | embryonic stage 16 | dominant phenotype of robo1¹

(Hsouna et al., 2003)

Scer\GAL4^elav.PLu/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is an enhancer of abnormal neuroanatomy | embryonic stage 16 | dominant phenotype of sli¹

(Hsouna et al., 2003)

Suppressor of

Statement

Reference

Scer\GAL4^elav.PLu/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is a suppressor of abnormal neuroanatomy phenotype of comm¹

(Hsouna et al., 2003)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS/Scer\GAL4^ftz.ng is a suppressor of abnormal neuroanatomy phenotype of comm¹

(Hsouna et al., 2003)

Scer\GAL4³¹/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is a suppressor of lethal phenotype of Abl¹/Df(3L)st-j7

(Fogerty et al., 1999)

Scer\GAL4³¹/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is a suppressor | partially of lethal phenotype of Abl¹/Df(3L)st-j7, Nrt^M2

(Fogerty et al., 1999)

Other

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has abnormal neuroanatomy | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹, Scer\GAL4³¹ has viable phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹, Scer\GAL4³¹ has visible phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Scer\GAL4³¹ has visible phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has visible phenotype

(Fogerty et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has commissure | embryonic stage 16 phenotype, enhanceable by fra^UAS.cKa, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has larval ventral nerve cord commissure | embryonic stage 16 phenotype, enhanceable by fra^UAS.cKa, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has commissure | embryonic stage 16 phenotype, enhanceable by fra^ΔP1.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has larval ventral nerve cord commissure | embryonic stage 16 phenotype, enhanceable by fra^ΔP1.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has commissure | embryonic stage 16 phenotype, enhanceable by fra^ΔP2.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has larval ventral nerve cord commissure | embryonic stage 16 phenotype, enhanceable by fra^ΔP2.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

NOT Enhanced by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has larval ventral nerve cord commissure phenotype, non-enhanceable by fra³/fra[+]

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has larval ventral nerve cord commissure phenotype, non-enhanceable by fra³/fra⁴/fra^UAS.cKa, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has larval ventral nerve cord commissure phenotype, non-enhanceable by fra^ΔP1.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has larval ventral nerve cord commissure phenotype, non-enhanceable by fra³/fra⁴/fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has larval ventral nerve cord commissure | embryonic stage 16 phenotype, non-enhanceable by fra^ΔP3.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^ftz.ng has commissure | embryonic stage 16 phenotype, non-enhanceable by fra^ΔP3.UAS, Scer\GAL4^ftz.ng

(Dorsten et al., 2007)

Suppressed by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has commissure | ectopic phenotype, suppressible | partially by fra^ΔP3.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has commissure | ectopic phenotype, suppressible by fra³/fra⁴

(Dorsten et al., 2010)

NOT suppressed by

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has larval ventral nerve cord commissure phenotype, non-suppressible by fra³/fra[+]

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has commissure | ectopic phenotype, non-suppressible by fra³/fra⁴/fra^UAS.cKa, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has commissure | ectopic phenotype, non-suppressible by fra^ΔP1.UAS/fra³/fra⁴, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407 has commissure | ectopic phenotype, non-suppressible by fra³/fra⁴/fra^ΔP2.UAS, Scer\GAL4^insc-Mz1407

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^P2.4.Pdf has ventral adult lateral neuron & axon phenotype, non-suppressible by Appl^d

(Leyssen et al., 2005)

Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is an enhancer of larval ventral nerve cord commissure phenotype of fra³/fra⁴

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS/Scer\GAL4^ftz.ng is an enhancer of larval longitudinal connective | embryonic stage 16 phenotype of robo1¹

(Hsouna et al., 2003)

Scer\GAL4^elav.PLu/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is an enhancer of larval longitudinal connective | embryonic stage 16 phenotype of sli¹

(Hsouna et al., 2003)

Suppressor of

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS/Scer\GAL4^ftz.ng is a suppressor of symmetrical commissure phenotype of comm¹

(Hsouna et al., 2003)

Scer\GAL4^elav.PLu/Abl::Hsap\ABL1::Hsap\BCR^P210.UAS is a suppressor of symmetrical commissure phenotype of comm¹

(Hsouna et al., 2003)

Other

Statement

Reference

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Scer\GAL4^insc-Mz1407, fra³/fra⁴ has tract | ectopic | embryonic stage phenotype

(Dorsten et al., 2010)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Scer\GAL4³¹ has eye phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Scer\GAL4³¹ has ommatidium phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has eye phenotype

(Fogerty et al., 1999)

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS, Abl¹/Df(3L)st-j7, Nrt^M2, Scer\GAL4³¹ has ommatidium phenotype

(Fogerty et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The lethality of Abl¹/Df(3L)st-j7 is rescued by Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} expressed under the control of Scer\GAL4³¹. The rescued flies are variably fertile and have rough eyes. The lethality of Abl¹/Nrt^M2 Df(3L)st-j7 is partially rescued by Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} expressed under the control of Scer\GAL4³¹. The rescued flies are fertile and have rough eyes.

(Fogerty et al., 1999)

Xenogenetic Interactions

Statement

Reference

Over-expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} using Scer\GAL4^insc-Mz1407 enhances the degree of thinning and missing posterior commissures in fra³/fra⁴ embryos, and many anterior commissures disappear. Large bundles of axons are observed ectopically exiting the central nervous system (CNS), often extending beyond the CNS/PNS boundary. The anterior commissures, which are virtually unaffected in fra³/fra⁴ embryos, are thin or missing in 41% of segments.

Fuzzy commissures remain evident in heterozygous fra³ embryos expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^insc-Mz1407.

Re-expression of fra^Scer\UAS.cKa in fra³/fra⁴ mutants reverts the phenotype back to that seen when Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} is expressed alone under the control of Scer\GAL4^insc-Mz1407 : fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP1.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP2.Scer\UAS} is able tor revert the commissure loss seen in fra³/fra⁴ mutants. These mutants display fuzzy commissures.

In fra³/fra⁴ mutants expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, expression of fra^{ΔP3.Scer\UAS} restores commissure formation in fra³/fra⁴ mutants. The frequency of fuzzy commissures is also significantly reduced.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}.

fra³/fra⁴ fails to reduce the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^Scer\UAS.cKa is co-expressed.

fra³/fra⁴ significantly reduces the frequency of ectopic axonal midline-crossovers resulting from the expression of Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} when fra^{ΔP3.Scer\UAS} is co-expressed.

Nearly a third of hemi-segments in fra³/fra⁴ embryos expressing Scer\GAL4^insc-Mz1407>Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} exhibit defects characterised by Fas2-positive axons ectopically exiting the central nervous system (CNS).

(Dorsten et al., 2010)

The frequency of neuronal crossover projections induced by Scer\GAL4^ftz.ng-driven expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} is significantly increased by co-expression of fra^Scer\UAS.cKa.

The frequency of neuronal crossover projections induced by Scer\GAL4^ftz.ng-driven expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} is not significantly increased by co-expression of fra^{ΔP3.Scer\UAS}.

(Dorsten et al., 2007)

Expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}, under the control of Scer\GAL4^P2.4.Pdf, in a Appl^d background still induces the axonal arborization phenotype that occurs when the transgene is expressed in a wild-type background.

(Leyssen et al., 2005)

Compared with heterozygous robo¹ mutants alone, expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} using Scer\GAL4^ftz.ng enhances the frequency of abnormal axonal crossovers. Almost every segment of every robo¹/+ embryo expressing Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} exhibits abnormal crossovers.

Pan-neural expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} in heterozygous sli¹ mutants results in a collapse of the longitudinal connectives towards the midline.

Pan-neural expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} under the control of Scer\GAL4^elav.PLu partially suppresses the comm¹ commissure phenotype.

Expression of Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS} in a subset of neurons under the control of Scer\GAL4^ftz.ng partially suppresses the comm¹ commissure phenotype.

(Hsouna et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9571

y¹ w^*; P{UAS-P210}31/CyO

Notes on Origin

Discoverer

Comments

The part of the chimeric construct derived from human sequences corresponds to the P210 BCR-ABL1 fusion protein found in chronic myelogenous leukemia.

(Fogerty et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Abl::Hsap\ABL1::Hsap\BCR^{P210.Scer\UAS}

Abl::Hsap\ABL1::Hsap\BCR^P210.UAS

Name Synonyms

Secondary FlyBase IDs

References (8)

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