FlyBase Allele Report: Dmel\Pex5[GD14972]

General Information

Symbol

Dmel\Pex5^GD14972

Species

D. melanogaster

Name

FlyBase ID

FBal0201007

Feature type

allele

Associated gene

Dmel\Pex5

Associated Insertion(s)

Carried in Construct

P{GD14972}

Also Known As

Pex5-i

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14972}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14972

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of peroxisomal biogenesis disorder

CEA

(Nath et al., 2022, Cara et al., 2018)

model of peroxisome biogenesis disorder 2A

CEC

(Pinelli et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of peroxisome biogenesis disorder 2A

is ameliorated by yki^UAS.cUa

(Pinelli et al., 2024)

model of peroxisomal biogenesis disorder

is ameliorated by Rho1^V14.E40L.UAS

(Nath et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell size | adult stage, with Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

increased cell death | adult stage, with Scer\GAL4^esg.PU

(Makdissi et al., 2025)

increased cell number | adult stage, with Scer\GAL4^esg.PU

(Makdissi et al., 2025)

increased cell number | adult stage, with Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

(Makdissi et al., 2025)

short lived | male, with Scer\GAL4^esg.PU

(Makdissi et al., 2025)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Pex5^GD14972 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development