FB2026_02 , released June 18, 2026
Allele: Dmel\PEKΔLD
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General Information
Symbol
Dmel\PEKΔLD
Species
D. melanogaster
Name
FlyBase ID
FBal0390365
Feature type
allele
Associated gene
Dmel\PEK
Associated Insertion(s)
TI{TI}PEKΔLD
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Monteiro et al., 2023)
Mutagen
CRISPR/Cas9
(Monteiro et al., 2023)
gene targeting by homologous recombination
(Monteiro et al., 2023)
Progenitor genotype
Associated Insertion(s)
TI{TI}PEKΔLD
Cytology
Description

The luminal domain (LD) is deleted and 3xTag:HA is inserted into endogenous PEK.

(Monteiro et al., 2023)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:5,461,414..5,464,315 [-]
Comment:

A 2902-bp deletion from Chr3R:5461414..5464315 . The deleted sequence is replaced by a 3xHA sequence. It also has silent mutations from “GG” to “AT” at Chr3R:5460966..5460967 to mutate the gRNA PAM sequence.

(Monteiro and Hurd, 2023.6.30)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      PEKΔLD is a non-suppressor of increased cell number | adult stage phenotype of Pex5GD14972, Scer\GAL4esg.PU

      (Makdissi et al., 2025)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      PEKΔLD
      PERK-ΔLD
      (Monteiro et al., 2023)
      PERKdeltaLD
      (Makdissi et al., 2025)
      PerkA
      (Makdissi et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)