FlyBase Allele Report: Dmel\dome[DN.UAS.cUa]

General Information

Symbol

Dmel\dome^DN.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0361038

Feature type

allele

Associated gene

Dmel\dome

Associated Insertion(s)

Carried in Construct

P{UAS-dome.DN.U}

Also Known As

UAS-dome^DN

Key Links

Transgenic product class

dominant_negative_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-dome.DN.U}

Cytology

Description

UAS regulatory sequences drive expression of a dominant-negative form of dome.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dome

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage, with Scer\GAL4^ey.PU

(Harsh et al., 2020)

decreased size | third instar larval stage, with Scer\GAL4^ey.PU

(Harsh et al., 2020)

visible | adult stage, with Scer\GAL4^ey.PU

(Harsh et al., 2020)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PU

(Harsh et al., 2020)

eye disc | third instar larval stage, with Scer\GAL4^ey.PU

(Harsh et al., 2020)

Detailed Description

Statement

Reference

Expression of dome^DN.UAS.cUa under the control of Scer\GAL4^ey.PU leads to a decrease in the size of eye and eye disc.

(Harsh et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^ey.PU, dome^DN.UAS.cUa has decreased size | third instar larval stage phenotype, enhanceable by ZIKV\NS4A^UAS.Tag:FLAG/Scer\GAL4^ey.PU

(Harsh et al., 2020)

Scer\GAL4^ey.PU, dome^DN.UAS.cUa has decreased size | adult stage phenotype, enhanceable by ZIKV\NS4A^UAS.Tag:FLAG/Scer\GAL4^ey.PU

(Harsh et al., 2020)

Scer\GAL4^ey.PU, dome^DN.UAS.cUa has visible | adult stage phenotype, enhanceable by ZIKV\NS4A^UAS.Tag:FLAG/Scer\GAL4^ey.PU

(Harsh et al., 2020)

Enhancer of

Statement

Reference

dome^DN.UAS.cUa/Scer\GAL4^ey.PU is an enhancer of decreased size | third instar larval stage phenotype of Scer\GAL4^ey.PU, ZIKV\NS4A^UAS.Tag:FLAG

(Harsh et al., 2020)

dome^DN.UAS.cUa/Scer\GAL4^ey.PU is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^ey.PU, ZIKV\NS4A^UAS.Tag:FLAG

(Harsh et al., 2020)

dome^DN.UAS.cUa/Scer\GAL4^ey.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^ey.PU, ZIKV\NS4A^UAS.Tag:FLAG

(Harsh et al., 2020)

Suppressor of

Statement

Reference

dome^DN.UAS.cUa, Scer\GAL4^esg.PU is a suppressor | partially of increased cell number | adult stage phenotype of Pex5^GD14972, Scer\GAL4^esg.PU

(Makdissi et al., 2025)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ey.PU, dome^DN.UAS.cUa has eye disc | third instar larval stage phenotype, enhanceable by ZIKV\NS4A^UAS.Tag:FLAG/Scer\GAL4^ey.PU

(Harsh et al., 2020)

Scer\GAL4^ey.PU, dome^DN.UAS.cUa has eye phenotype, enhanceable by ZIKV\NS4A^UAS.Tag:FLAG/Scer\GAL4^ey.PU

(Harsh et al., 2020)

Enhancer of

Statement

Reference

dome^DN.UAS.cUa/Scer\GAL4^ey.PU is an enhancer of eye disc | third instar larval stage phenotype of Scer\GAL4^ey.PU, ZIKV\NS4A^UAS.Tag:FLAG

(Harsh et al., 2020)

dome^DN.UAS.cUa/Scer\GAL4^ey.PU is an enhancer of eye phenotype of Scer\GAL4^ey.PU, ZIKV\NS4A^UAS.Tag:FLAG

(Harsh et al., 2020)

Suppressor of

Statement

Reference

dome^DN.UAS.cUa, Scer\GAL4^esg.PU is a suppressor | partially of intestinal stem cell of posterior adult midgut epithelium | increased number phenotype of Pex5^GD14972, Scer\GAL4^esg.PU

(Makdissi et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dome^DN.UAS.cUa

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close