Gene model reviewed during 5.54
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Gene model reviewed during 6.01
There is only one protein coding transcript and one polypeptide associated with this gene
A smaller Parp protein which is generated from an alternatively spliced mRNA lacks the auto-modification domain.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Parp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Parp in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG17718, CG17696 and CG17685 merged as CG40411 in release 3 of the genome annotation.
Sequence of transcript(s) changed in r6 genomic release relative to r5 release.
Parp is required to produce normal-sized polytene chromosome puffs and normal amounts of Hsp70 protein after heat exposure.
Nucleoli fail to form in Parp mutants, heterochromatic (but not euchromatic) sequences become sensitive to micrococcal nuclease and the transcript levels of the copia retrotransposon are elevated more than 50-fold.
Overexpression of Parp disrupts the organisation of the F-actin cytoskeleton, resulting in aberrant cell and tissue morphology.
The genomic organisation of the Parp locus and its expression pattern during development have been analysed.
PARP protein is processed in S2 cells treated with etoposide to induce apoptosis.
Amino acid sequence of Parp cDNA has been compared between different species with an emphasis on conservation of functional elements and expression during development.
Full length cDNA clones for Drosophila poly(ADP-ribose) polymerase isolated using a probe made by PCR with primers deduced from sequence in mammal, chicken, fish and amphibian species.