FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term NAD+ poly-ADP-ribosyltransferase activity ID (Ontology) GO:0003950 (Gene Ontology)
Definition Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.[ EC:2 ]
Also Known As "NAD ADP-ribosyltransferase activity"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       4
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 NAD+ poly-ADP-ribosyltransferase activity (all annotations which use CV term, excluding "NOT" statements)       1      4
     enables | NAD+ poly-ADP-ribosyltransferase activity       --       4
Spanning Tree (Parents/Children)
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  glycosyltransferase activity
   |__pentosyltransferase activity
       |__NAD+ poly-ADP-ribosyltransferase activity  5 rec.
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Is a pentosyltransferase activity
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Synonyms
  • "ADP-ribosyltransferase (polymerizing) activity" RELATED[ EC:2 ]
    "NAD ADP-ribosyltransferase activity" EXACT
    "NAD+ ADP-ribosyltransferase activity" BROAD
    "NAD+-protein poly-ADP-ribosyltransferase activity" NARROW
    "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" RELATED[ EC:2 ]
    "poly(adenosine diphosphate ribose) polymerase activity" RELATED[ EC:2 ]
    "poly(ADP-ribose) synthase activity" RELATED[ EC:2 ]
    "poly(ADP-ribose) synthetase activity" RELATED[ EC:2 ]
    "poly(ADP-ribose)polymerase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.4.2.30
MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN
Reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4"
Reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN"
Reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate"
Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate"
Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD"
Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)"
Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN"
Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated"
Reactome:R-HSA-9729279 "Nucleoprotein is ADP-ribosylated"