FlyBase Gene Report: Dmel\His2A

General Information

Symbol

Dmel\His2A

Species

D. melanogaster

Name

Histone H2A

Annotation Symbol

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001196

Gene Model Status

Not Applicable

Stock Availability

30 publicly available

Gene Summary

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in recruitment of Parp1 to chromatin and regulates its activity; the N-terminal tail inhibits histone H4-dependent activation of Parp1 (PubMed:17827147, PubMed:24508391). (UniProt, P84051)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

H2A, histone, core histone, HisC, dH2A

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR002119, InterPro:IPR007125

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Matsuo and Yamazaki, 1989)

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(InterPro Project Members, 2004-)

enables structural constituent of chromatin

inferred from electronic annotation with InterPro:IPR002119

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in larval somatic muscle development

inferred from mutant phenotype

(Schnorrer et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from sequence or structural similarity with MGI:MGI:2448285

(Gene Ontology Curators, 2002-)

involved_in heterochromatin formation

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

involved_in nucleosome assembly

non-traceable author statement

(Matsuo and Yamazaki, 1989)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in chromosome

inferred from direct assay

(Leach et al., 2000)

located_in nucleus

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome band

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome

inferred from direct assay

(Leach et al., 2000)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of nucleosome

non-traceable author statement

(Matsuo and Yamazaki, 1989)

inferred from electronic annotation with InterPro:IPR002119

(InterPro Project Members, 2004-)

traceable author statement

(Leach et al., 2000)

inferred from sequence or structural similarity with UniProtKB:Q7L7L0

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000604564

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the histone H2A family. (P84051)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, P84051)

Summary (Interactive Fly)

Chromatin component - a core histone that can be modified by ubiquitination - a target of polycomb gene silencing - involved in trans-histone regulation through histone H3 - H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P84051)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Parp1 (via C-terminus); the interaction is direct and regulates Parp1 enzymatic activity (PubMed:17827147).

(UniProt, P84051)

Post Translational Modification

The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', disassembly of the synaptonemal complex, and karyosome formation.

Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression (PubMed:15386022). Deubiquitinated by the polycomb repressive deubiquitinase (PR-DUB) complex (PubMed:20436459, PubMed:30258054, PubMed:30639226).

Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).

(UniProt, P84051)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\His2A using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14

central nervous system

Comment: replicating cells

(Lanzotti et al., 2002)

midgut | restricted

Comment: endoreplicating cells

(Lanzotti et al., 2002)

Additional Descriptive Data

His2A transcript is restricted to replicating cells.

(Lanzotti et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

fertilized egg stage

female pronucleus

• chromatin

(Loppin et al., 2001)

male pronucleus

• chromatin

(Loppin et al., 2001)

adult stage

spermatozoon

• chromatin

(Loppin et al., 2001)

spermatogenesis

elongation stage spermatid

• chromatin

(Loppin et al., 2001)

pre-elongation spermatid

• chromatin

(Loppin et al., 2001)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

His4 and His2A that was mono or poly acetylated is detected associated with nuclei of developing spermatids until late stages. During late spermatid development and in mature spermatazoa these proteins can no longer be detected (and are presumably replaced by sperm specific chromatin packaging proteins). However, shortly after fertilization His4 and His2A immunoreactivity reappears associated with the male pronuclear DNA.

(Loppin et al., 2001)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in chromosome

inferred from direct assay

(Leach et al., 2000)

located_in nucleus

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome band

inferred from direct assay

(Leach et al., 2000)

located_in polytene chromosome

inferred from direct assay

(Leach et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\His2A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\His2A

View exonic expression by tissue for Dmel\His2A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 38 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of His2A

Transgenic constructs containing regulatory region of His2A

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)C239

(Moore et al., 1981)

Df(2L)His^C

(Günesdogan et al., 2010)

Df(2L)HisC-cadillac

(Crain et al., 2024, Crain et al., 2024)

Df(2L)His-D

(Zhang et al., 2019)

Gene duplicated in

Dp(2;1)C239

(Moore et al., 1981)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

His2A^GD15048

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

His2A^GD15048

Phenotype manifest in

Allele

larval somatic muscle cell, with Scer\GAL4^Mef2.PR

His2A^GD15048

sarcomere, with Scer\GAL4^Mef2.PR

His2A^GD15048

Z disc, with Scer\GAL4^Mef2.PR

His2A^GD15048

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:His2A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

His2A^GL00226

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

His2A

split luciferase complementation, luminiscence technology, pull down, western blot

(Kolkhof et al., 2017, Fei et al., 2015)

His2A - Acf

pull down, molecular weight estimation by staining

(Eberharter et al., 2004)

His2A - Art8

enzymatic study, autoradiography

(Villar-Garea et al., 2012)

His2A - CG11700

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

His2A - Caf1-55

pull down, autoradiography

(Tie et al., 2007)

His2A - Dek

pull down, western blot, affinity technology, ion exchange chromatography, Identification by mass spectrometry, anti tag coimmunoprecipitation

(Sawatsubashi et al., 2010)

His2A - E(z)

pull down, Identification by mass spectrometry

(Kalb et al., 2014)

His2A - Fkbp39

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Edlich-Muth et al., 2015)

His2A - His1

nuclear magnetic resonance, predetermined participant, cosedimentation, molecular weight estimation by staining

(Zhou et al., 2016, Zhou et al., 2013)

His2A - His2Av

split luciferase complementation, luminiscence technology

(Kolkhof et al., 2017)

His2A - His2B

molecular sieving, molecular weight estimation by staining, split luciferase complementation, luminiscence technology, cosedimentation, cross-linking study, cosedimentation through density gradient, affinity chromatography technology

(Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Anderson et al., 2010, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2A - His3

cosedimentation, molecular weight estimation by staining, cosedimentation through density gradient, molecular sieving

(Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2A - His4

molecular sieving, molecular weight estimation by staining, split luciferase complementation, luminiscence technology, cosedimentation, cosedimentation through density gradient

(Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2A - Jabba

split luciferase complementation, luminiscence technology

(Stephenson et al., 2021, Kolkhof et al., 2017)

His2A - Jarid2

pull down, Identification by mass spectrometry

(Kalb et al., 2014)

His2A - Nap1

anti bait coimmunoprecipitation, western blot, cosedimentation through density gradient, molecular weight estimation by staining, cosedimentation

(Emelyanov et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)

His2A - Nlp

cosedimentation, molecular weight estimation by staining, anti bait coimmunoprecipitation, cosedimentation through density gradient

(Emelyanov et al., 2014, Ito et al., 1996)

His2A - Nph

cosedimentation through density gradient, molecular weight estimation by staining

(Emelyanov et al., 2014)

His2A - P32

cosedimentation through density gradient, molecular weight estimation by staining

(Emelyanov et al., 2014)

His2A - Parp1

pull down, western blot

(Thomas et al., 2014)

His2A - Pc

affinity technology, peptide array, western blot

(Stein et al., 2013)

His2A - Sce

enzymatic study, western blot

(Lagarou et al., 2008)

His2A - Tip60

enzymatic study, autoradiography

(Kusch et al., 2014)

His2A - Trl

anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2024)

His2A - cid

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Zhang et al., 2012, Dalal et al., 2007)

His2A - esc

pull down, Identification by mass spectrometry

(Kalb et al., 2014)

His2A - mof

enzymatic study, autoradiography

(Smith et al., 2000)

RNA-protein

Physical Interaction

Assay

References

His2A - vig

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, electrophoretic mobility shift assay, autoradiography

(Tsui et al., 2018)

His2A - vig2

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(Tsui et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

(UniProt, P84051 )

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_array_member

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

39D3-39E1

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39D3-39E1

Left limit from in situ hybridisation (FBrf0029738) Right limit from inclusion within Df(2L)L138D-XR (citation unavailable)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

39D-39E

(determined by in situ hybridisation)

(Fitch et al., 1990, Lifton et al., 1978)

39D3-39E2

(determined by in situ hybridisation)

(Pardue et al., 1977)

Experimentally Determined Recombination Data

Location

2-55

Left of (cM)

Right of (cM)

Notes

2-^54.6

Stocks and Reagents

Stocks (30)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

94172

w^*; P{mir-958-His2A.GFP.0.4}attP40

94173

w^*; P{mir-958-His2A.GFP.1.4}attP40

14346

y¹ w^67c23; P{SUPor-P}His2A^KG00275

65302

w^*; PBac{3xHisGU.H3K56R}VK00027 PBac{3xHisGU.H3K56R}VK00033

65304

w^*; PBac{3xHisGU.H3K115Q}VK00027 PBac{3xHisGU.H3K115Q}VK00033

65306

w^*; PBac{3xHisGU.H3K115R}VK00027 PBac{3xHisGU.H3K115R}VK00033

65312

w^*; PBac{3xHisGU.H3T118A}VK00027 PBac{3xHisGU.H3T118A}VK00033

65314

w^*; PBac{3xHisGU.H3T118I}VK00027 PBac{3xHisGU.H3T118I}VK00033

1534R-1

v109087

v109090

v39116

w¹¹¹⁸; P{GD15048}v39116

More stocks available...

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Doyen et al., 2013, Egelhofer et al., 2011)

monoclonal

(Egelhofer et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The ATPase activity of Iswi is completely inhibited by each of the four histone tails (His2A, His2B, His3 and His4), results indicate a novel role for the flexible histone tails in chromatin remodeling by Iswi.

(Georgel et al., 1997)

The codon bias of the histone genes from D.melanogaster and D.hydei illustrates that the generalisation that abundantly expressed genes have a high codon bias and low rates of silent substitution does not hold for the histone genes.

(Fitch and Strausbaugh, 1993)

The position of the homologous histone gene repeats within the nuclei of early embryo cells has been investigated. The two homologous histone gene clusters are distinct and separate through all stages of the cell cycle up to nuclear cycle 13. During interphase of cycle 14, the two clusters colocalise with high frequency, and move from near the midline of the nucleus towards the apical side.

(Hiraoka et al., 1993)

DNA replication of the 5kb histone gene repeating unit in tissue culture cells (Drosophila Kc cells) initiates at multiple sites located within the repeating unit. Several replication pause sites are located at 5' upstream regions of some histone genes.

(Shinomiya and Ina, 1993)

DNaseI footprinting analysis reveals core histones His2A, His2B, His3 and His4 (but not His1) bind to the kni, Kr and Ubx minimal enhancer elements in a periodic manner.

(Kerrigan and Kadonaga, 1992)

The genomic organisation of the histone genes in D.hydei closely resembles that of D.melanogaster.

(Kremer and Hennig, 1990)

One H2A-like sequence variant has been found (Donahue, Palmer, Condie, Sabatini, and Blumenfeld, 1986); see His2Av.

Encodes Histone-2A. See HIS-C record.

Relationship to Other Genes

Source for database merge of

Encoded by

HIS-C

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

DmeH2a

(Fitch and Strausbaugh, 1993)

H2_A

(Amati and Gasser, 1990)

H2A

(Karling and Weavers, 2025, Pérez-Roldán et al., 2025, Gilbert et al., 2024, Hunt and Mannervik, 2024, Kurshakova et al., 2024, Parreno et al., 2024, Zhang et al., 2024, Zhao et al., 2024, Corcoran and Jacob, 2023, Dubruille et al., 2023, Erokhin et al., 2023, Hodkinson et al., 2023, Tirgar et al., 2023, Zhang et al., 2023, Bonnet et al., 2022, Ranjan and Chen, 2022, Urban et al., 2022, Chaouch and Lasko, 2021, Cho et al., 2021, Endo et al., 2021, Khan et al., 2021, Llorens-Giralt et al., 2021, Matsuo, 2021, Okimune et al., 2021, Stephenson et al., 2021, Tilly et al., 2021, Zhang et al., 2021, Barbour et al., 2020, Kolesnikova et al., 2020, Kuroda et al., 2020, Morgan and Shilatifard, 2020, Okimune et al., 2020, Pirani et al., 2020, Tarczewska et al., 2020, Wooten et al., 2020, Chittori et al., 2019, Wooten et al., 2019, Yang et al., 2019, Armstrong et al., 2018, Daou et al., 2018, Tsui et al., 2018, Zheng et al., 2018, Janssens et al., 2017, Khuong et al., 2017, Kitevski-LeBlanc et al., 2017, Kolkhof et al., 2017, Ramachandran et al., 2017, Rieder et al., 2017, Rowley et al., 2017, Strom et al., 2017, Yang and Ioshikhes, 2017, Bayona-Feliu et al., 2016, Doiguchi et al., 2016, Elnfati et al., 2016, Kahn et al., 2016, Kavi et al., 2016, Messina et al., 2016, Nakashima et al., 2016, Ozawa et al., 2016, Penke et al., 2016, Shih et al., 2016, Zhou et al., 2016, Edlich-Muth et al., 2015, Fei et al., 2015, Horard and Loppin, 2015, Pengelly et al., 2015, Emelyanov et al., 2014, Fereres et al., 2014, Klinker et al., 2014, Kusch et al., 2014, Landais et al., 2014, Messina et al., 2014, Thomas et al., 2014, Bharadwaj et al., 2013, Doyen et al., 2013, Eichinger et al., 2013, Guglielmi et al., 2013, Schaaf et al., 2013, Stein et al., 2013, Wang et al., 2013, Xing et al., 2013, Zhou et al., 2013, Dunlap et al., 2012, Gutiérrez et al., 2012, Ito et al., 2012, Li et al., 2012, Li et al., 2012, Lo et al., 2012, Villar-Garea et al., 2012, Xie et al., 2012, Zhou et al., 2012, Chen et al., 2011, Egelhofer et al., 2011, Gibert and Karch, 2011, Lorbeck et al., 2011, Olins et al., 2011, Regnard et al., 2011, Siudeja et al., 2011, Anderson et al., 2010, Beck et al., 2010, Bryson et al., 2010, Deal et al., 2010, Guertin and Lis, 2010, Lancaster et al., 2010, Makde et al., 2010, Sawatsubashi et al., 2010, Scheuermann et al., 2010, Weber et al., 2010, Kolesnikova et al., 2009, Lu et al., 2009, Morciano et al., 2009, Sakai et al., 2009, Sullivan et al., 2009, Bao et al., 2008, Barreau et al., 2008, Cakouros et al., 2008, Clapier et al., 2008, Frydrychova et al., 2008, Hanai et al., 2008, Krajewski, 2008, Lagarou et al., 2008, Bell et al., 2007, Camporeale et al., 2007, Corona et al., 2007, Dalal et al., 2007, Dalal et al., 2007, Isogai et al., 2007, Pinnola et al., 2007, Rathke et al., 2007, Tie et al., 2007, Wagner et al., 2007, Wagner et al., 2007, Brasaemle and Hansen, 2006, Camporeale et al., 2006, Furuyama et al., 2006, Mendjan et al., 2006, Raisner and Madhani, 2006, Santoso and Kadonaga, 2006, Dudnik et al., 2005, Ivanovska et al., 2005, Jin, 2005, Lusser et al., 2005, Aihara et al., 2004, Kusch et al., 2004, Kusch et al., 2004, Lippman and Martienssen, 2004, Morales et al., 2004, Wang et al., 2004, Furukawa et al., 2003, Kakita et al., 2003, Schwartz et al., 2003, Staeva-Vieira et al., 2003, Blower and Karpen, 2002, Cao et al., 2002, Clapier et al., 2002, Levenstein and Kadonaga, 2002, Smith, 2002, Yu and Wolfner, 2002, Berloco et al., 2001, Hamiche et al., 2001, Katsani et al., 2001, Loppin et al., 2001, Mello and Almouzni, 2001, Mizuguchi et al., 2001, Nakagawa et al., 2001, Kal et al., 2000, Leach et al., 2000, Mizzen and Allis, 2000, Pham and Sauer, 2000, Smith et al., 2000, Verreault, 2000, Baldo et al., 1999, Borgnetto et al., 1999, Carrier et al., 1999, Hamiche et al., 1999, Reim et al., 1999, Stuckenholz et al., 1999, Schienman et al., 1998, Sobel et al., 1998, Strausbaugh et al., 1998, Walker and Bownes, 1998, Georgel et al., 1997, Grunstein, 1997, Ito et al., 1996, Ito et al., 1996, Sommer and Strausbaugh, 1996, Strausbaugh and Williams, 1996, Wolffe and Pruss, 1996, Blank and Becker, 1995, Sobel et al., 1994, O'Brien and Lis, 1993, Shinomiya and Ina, 1993, Becker and Wu, 1992, Kas and Laemmli, 1992, Kerrigan and Kadonaga, 1992, Pauli et al., 1992, Harisanova and Ralchev, 1991, Harisanova et al., 1991, O'Brien and Lis, 1991, Udvardy and Schedl, 1991, Fitch et al., 1990, Kremer and Hennig, 1990, Domier et al., 1986, Levinger and Varshavsky, 1982)

H2A.1

(Clarkson et al., 1999, van Daal et al., 1988)

H2A1

(Redon et al., 2002)

H2a

(Koreski et al., 2020, Welch et al., 2015, Salzler et al., 2013, Godfrey et al., 2006, Dominski et al., 2002, Lanzotti et al., 2002, Rodriguez-Trelles et al., 2000, Shinomiya and Ina, 1991)

His2a

(Shopland and Lis, 1996)

HisC

(Greil et al., 2003, van Steensel et al., 2001)

dH2A

(Brittle et al., 2007, Dominski et al., 2005)

dH2a

(Yang et al., 2009)

his

(Matsushima and Kaguni, 2007)

his2A

(Wang et al., 2025, Kelleher, 2021)

hist

(Häsemeyer et al., 2009)

histone

(Corpet and Almouzni, 2007)

Name Synonyms

Histone

(Hutterer et al., 2006, Parsons et al., 2003, Breiling et al., 1999)

Histone 2A

(Lu et al., 2009)

Histone H2A

Histone2A

(Keranen et al., 2006)

HistoneH2A

(Kurihara et al., 2020)

core histone

(Xia et al., 2003, Livengood et al., 2002)

histone H2A

(Scheuermann et al., 2010, Bao et al., 2008, Lagarou et al., 2008, Hyllus et al., 2007, Pinnola et al., 2007, Rathke et al., 2007, Rathke et al., 2007, Ringrose and Paro, 2007, Muller and Kassis, 2006)

histone H2a

(Godfrey et al., 2006, Lanzotti et al., 2002)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P84051

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P84051

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P84051

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (415)

NA

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