FlyBase Allele Report: Dmel\Moe[NES]

General Information

Symbol

Dmel\Moe^NES

Species

D. melanogaster

Name

FlyBase ID

FBal0369714

Feature type

allele

Associated gene

Dmel\Moe

Associated Insertion(s)

TI{TI}Moe^NES

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Bajusz et al., 2021)

gene targeting by homologous recombination

(Bajusz et al., 2021)

Progenitor genotype

Associated Insertion(s)

TI{TI}Moe^NES

Cytology

Description

A nuclear export signal (Tag:NES(hPKIA)) has been inserted into the endogenous Moe locus, immediately upstream of the stop codon in the 14th exon that is present in all transcript isoforms. A single loxP site is also present, in the last intron.

(Bajusz et al., 2021)

Allele components

Component

Use(s)

Tagged with

Tag:NES(hPKIA)

nuclear export signal

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | female (with Moe^G0415)

(Bajusz et al., 2021)

abnormal developmental rate | male

(Bajusz et al., 2021)

abnormal locomotor behavior | male

(Bajusz et al., 2021)

decreased size | maternal effect | oogenesis (with Moe^G0415)

(Bajusz et al., 2021)

decreased size | maternal effect | spermatogenesis (with Moe^G0415)

(Bajusz et al., 2021)

fertile | paternal effect

(Bajusz et al., 2021)

grandchildless | female (with Moe^G0415)

(Bajusz et al., 2021)

majority die during embryonic stage | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

short lived | female | heat sensitive (with Moe^G0415)

(Bajusz et al., 2021)

short lived | male

(Bajusz et al., 2021)

some die during embryonic stage | maternal effect

(Bajusz et al., 2021)

some die during larval stage | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

some die during P-stage | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

sterile | dominant | maternal effect

(Bajusz et al., 2021)

sterile | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

viable | female (with Moe^G0415)

(Bajusz et al., 2021)

viable | male

(Bajusz et al., 2021)

visible | adult stage | male

(Bajusz et al., 2021)

visible | adult stage | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

Phenotype Manifest In

abdominal tergite | adult stage | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

crossvein | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

eye | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

male genitalia

(Bajusz et al., 2021)

male genitalia | absent | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

ovary | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

testis | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

wing margin | maternal effect (with Moe^G0415)

(Bajusz et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Moe^NES

moe^NES

(Bajusz et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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