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Citation
Chen, F., Krasnow, M.A. (2014). Progenitor outgrowth from the niche in Drosophila trachea is guided by FGF from decaying branches.  Science 343(6167): 186--189.
FlyBase ID
FBrf0223781
Publication Type
Research paper
Abstract

Although there has been progress identifying adult stem and progenitor cells and the signals that control their proliferation and differentiation, little is known about the substrates and signals that guide them out of their niche. By examining Drosophila tracheal outgrowth during metamorphosis, we show that progenitors follow a stereotyped path out of the niche, tracking along a subset of tracheal branches destined for destruction. The embryonic tracheal inducer branchless FGF (fibroblast growth factor) is expressed dynamically just ahead of progenitor outgrowth in decaying branches. Knockdown of branchless abrogates progenitor outgrowth, whereas misexpression redirects it. Thus, reactivation of an embryonic tracheal inducer in decaying branches directs outgrowth of progenitors that replace them. This explains how the structure of a newly generated tissue is coordinated with that of the old.

PubMed ID
PubMed Central ID
PMC3966907 (PMC) (EuropePMC)
Related Publication(s)
Note

Stem cells: moving out of the niche.
Baumann, 2014, Nat. Rev. Mol. Cell Biol. 15(2): 79 [FBrf0224530]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075 1095-9203
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