FlyBase Allele Report: Dmel\Moe[KN.UASp.GFP]

General Information

Symbol

Dmel\Moe^KN.UASp.GFP

Species

D. melanogaster

Name

FlyBase ID

FBal0280253

Feature type

allele

Associated gene

Dmel\Moe

Associated Insertion(s)

Carried in Construct

P{UASp-Moe.GFP.KN}

Key Links

Transgenic product class

missense_variant

(Roch et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Roch et al., 2010)

Mutagen

in vitro construct

(Roch et al., 2010)

Progenitor genotype

Carried in construct

P{UASp-Moe.GFP.KN}

Cytology

Description

UASp regulatory sequences drive expression of a mutant Moe carrying amino acid substitutions K254N, K255N, K263N and K264N fused with GFP.

(Roch et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Moe

Tagged with

GFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Moe^PL106, Scer\GAL4^αTub84B.PL

(Roch et al., 2010)

visible, with Moe^PL106, Scer\GAL4^αTub84B.PL

(Roch et al., 2010)

Phenotype Manifest In

eye, with Moe^PL106, Scer\GAL4^αTub84B.PL

(Roch et al., 2010)

wing blade, with Moe^PL106, Scer\GAL4^αTub84B.PL

(Roch et al., 2010)

Detailed Description

Statement

Reference

Expression of Moe^{KN.Scer\UAS.P\T.T:Avic\GFP} using Scer\GAL4^αTub84B.PL slightly enhances the viability of Moe^PL106, however, the escapers display rough eyes and crumpled wings.

(Roch et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Moe^KN.UASp.GFP/Scer\GAL4^αTub84B.PL partially rescues Moe^PL106

(Roch et al., 2010)

Fails to rescue

Moe^KN.UASp.GFP/Scer\GAL4^αTub84B.PL fails to rescue Moe^PL54

(Roch et al., 2010)

Comments

Expression of Moe^{KN.Scer\UAS.P\T.T:Avic\GFP} using Scer\GAL4^αTub84B.PL slightly enhances the viability of Moe^PL106, however, the escapers display rough eyes and crumpled wings.

(Roch et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Moe^{KN.Scer\UAS.P\T.T:Avic\GFP}

Moe^KN.UASp.GFP

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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