FlyBase Gene Report: Dmel\lov

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\lov

General Information

Symbol

Dmel\lov

Species

D. melanogaster

Name

jim lovell

Annotation Symbol

CG16778

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266129

Gene Model Status

Stock Availability

55 publicly available

Gene Summary

Has a regulatory role during midline cell development. (UniProt, P14083)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Tkr, dTKR, BTB-III, 91Y, Tyrosine kinase-related protein

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:25,085,780..25,139,627 [-]

Recombination map

2-107

RefSeq locus

NT_033778 REGION:25085780..25139627

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR007889

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in gravitaxis

inferred from mutant phenotype

(Armstrong et al., 2006)

involved_in larval feeding behavior

inferred from mutant phenotype

(Bjorum et al., 2013)

involved_in larval walking behavior

inferred from mutant phenotype

(Bjorum et al., 2013)

involved_in male courtship behavior

inferred from mutant phenotype

(Bjorum et al., 2013)

involved_in negative gravitaxis

inferred from mutant phenotype

(Bjorum et al., 2013)

involved_in oogenesis

inferred from mutant phenotype

(Bjorum et al., 2013)

involved_in ventral midline development

inferred from mutant phenotype

(Wheeler et al., 2006)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN001135010

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN001135010

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PIPSQUEAK TRANSCRIPTION FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PIPSQUEAK TRANSCRIPTION FACTORS -: Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).

Protein Function (UniProtKB)

Has a regulatory role during midline cell development.

(UniProt, P14083)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Tkr: Tyrosine kinase related

No mutant phenotype identified as yet. Transcripts initially expressed in the syncytial blastoderm stage (Haller et al., 1987; Cote et al., 1987), accumulating temporarily at dorsal-lateral positions in the embryo. At the end of blastoderm, the transcripts accumulate unevenly and are restricted to the dorsal region along 20-85% of the egg length. During gastrulation they are found in the dorsal region of the cephalic furrow and cover the neurogenic ectoderm in the procephalic region, disappearing from anterior to posterior during the extended germband stage. Later Tkr is expressed anew in the developing nervous system, including the brain, but disappears completely at the end of embryogenesis (Haller et al., 1987).

Summary (Interactive Fly)

BTB/POZ zinc finger transcription factor - required for endopolyploid growth in larval trachea - functions in the late specification of several classes of sensory neurons - mutant larvae show feeding and locomotor defects

Interactive Fly

Gene Model and Products

Number of Transcripts

5

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\lov for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P14083)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Shares 5' UTR with upstream gene.

Low-frequency RNA-Seq exon junction(s) not annotated.

Stop-codon suppression (UGA) postulated; FBrf0216884

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0072457

4458

1046

FBtr0072458

4497

1046

FBtr0100126

4712

1046

FBtr0330231

3826

1143

FBtr0343605

4185

1046

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0072359

112.3

1046

6.19

FBpp0072360

112.3

1046

6.19

FBpp0099472

112.3

1046

6.19

FBpp0303264

123.2

1143

6.43

FBpp0310200

112.3

1046

6.19

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1046 aa isoforms: lov-PB, lov-PC, lov-PD, lov-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lov using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lov_1
lov_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.41

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

amnioserosa anlage

(Fisher et al., 2012)

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

lateral head epidermis

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa primordium

(Fisher et al., 2012)

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 11

embryonic posterior midline glial cell

(Wheeler et al., 2006)

VUM precursor | subset

(Wheeler et al., 2006)

(Wheeler et al., 2006)

embryonic stage 11 -- 12

dorsal head epidermis primordium

(Fisher et al., 2012)

midline primordium

(Fisher et al., 2012)

embryonic stage 13

larval VUM motor neuron | subset

(Wheeler et al., 2006)

larval VUM interneuron

(Wheeler et al., 2006)

lineage MNB primary interneuron

(Wheeler et al., 2006)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

larval midline neuron

(Kearney et al., 2004)

embryonic stage 17

larval VUM motor neuron | subset

(Wheeler et al., 2006)

larval VUM interneuron

(Wheeler et al., 2006)

lineage MNB primary interneuron

(Wheeler et al., 2006)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 10

organism | dorso-lateral

(Cote et al., 1987)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 9

Comment: transcripts lov-RA, RB, and RC

(Bjorum et al., 2013)

embryonic stage 15 -- 17

larval central nervous system

Comment: transcripts lov-RD and RB

(Bjorum et al., 2013)

adult stage | male

Comment: transcript lov-RF

(Bjorum et al., 2013)

Comment: transcripts lov-RB and RD

(Bjorum et al., 2013)

Additional Descriptive Data

Distinct isoform-specific expression profiles observed for four lov transcripts. Transcript lov-RA (now lov-RF) is testis-specific and is first detected in early pupal stages as the male gonad begins final development. lov-RC is almost completely limited to early embryo expression. Transcript lov-RD appears to be the dominant neural transcript and is higher in adult head than some and is strongly expressed in late embryos in neural tissues. Transcript lov-RB is stronger in adult head than soma and is seen in early embryos. It is low in larvae but reappears during pupal remodeling.

(Bjorum et al., 2013)

Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

(Wheeler et al., 2006)

Expression pattern inferred from unspecified enhancer trap line.

(Kearney et al., 2004)

From the syncytial blastoderm stage to the early extended germ band stage of embryogenesis, lov transcript is detected in a longitudinal stripe extending dorsally and laterally. Expression slowly dissappears, from posterior to anterior, and from lateral to dorsal. By the end of germ band extension, lov transcript is restricted to amnioserosa cells.

(Cote et al., 1987)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

cephalic furrow

(Bjorum et al., 2013)

anterior transverse furrow

(Bjorum et al., 2013)

posterior transverse furrow

(Bjorum et al., 2013)

amnioproctodeal invagination

(Bjorum et al., 2013)

embryonic stage 9 -- 12

procephalic neurogenic region

(Bjorum et al., 2013)

embryonic stage 11 -- 12

(Bjorum et al., 2013)

dorsal ectoderm

(Bjorum et al., 2013)

lateral ectoderm

(Bjorum et al., 2013)

ventral midline of embryo

(Bjorum et al., 2013)

embryonic stage 13 -- 17

larval central nervous system | restricted

(Bjorum et al., 2013)

larval peripheral nervous system | restricted

(Bjorum et al., 2013)

embryonic stage 15

pentascolopidial chordotonal organ

(Bjorum et al., 2013)

external sensory organ

(Bjorum et al., 2013)

multidendritic neuron

Comment: tracheal dendrite class

(Bjorum et al., 2013)

larval abdominal lch5-2 neuron

(Bjorum et al., 2013)

(Bjorum et al., 2013)

Additional Descriptive Data

lov protein is expressed in broad dorsal and lateral regions of the cellular blastoderm embryo. At early germ band extension, the expression is found in the cephalic furrow, the anterior and posterior transverse furrows, and the amnioproctodeal invagination. Strong expression is seen in the precephalic neurogenic region. At full germ band extension, expression is seen in the dorsolateral ectoderm. After germ band retraction, expression is observed first in a single nucleus in the midline of each thoracic and abdominal segment. Additional midline and lateral CNS nuclei then begin expression and a mesh-like pattern in the CNS appears. Expression is also observed in selected cells in the PNS. The lov-positive PNS neurons were identified as external sense organs, all three tracheal dendrite neurons and two of the eight chordotonal organ neurons (lch2 and lch4) in each hemisegment.

(Bjorum et al., 2013)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lov in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lov

View exonic expression by tissue for Dmel\lov

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266129

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38007/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266129

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003715

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266129

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16778

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lov

Transgenic constructs containing regulatory region of lov

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

(Cote et al., 1987)

(Duman-Scheel et al., 1997, Cote et al., 1987)

(Duman-Scheel et al., 1997, Cote et al., 1987)

Gene partially disrupted in

(He and Noll, 2013)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^c204

lov^UAS.cBa

partially lethal - majority die, with Scer\GAL4^c355

lov^UAS.cBa

partially lethal - majority die, with Scer\GAL4^c532

lov^UAS.cBa

partially lethal - majority live

lov⁴⁷

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lov^GD4499

viable, with Scer\GAL4^pnr-MD237

lov^GD4499

viable, with Scer\GAL4^tin.CΔ4

lov^GD4499

viable, with Scer\GAL4^{VP16.nanos.UTR}

lov^UAS.cBa

Sterility

Allele

female semi-sterile (with Df(2R)Kr10)

lov⁶⁶

female semi-sterile | recessive

lov⁶⁶

fertile (with Df(2R)Kr10)

lov⁴⁷

Other Phenotypes

Allele

abnormal body size | adult stage

lov⁴⁷

abnormal body size | adult stage (with Df(2R)Kr10)

lov⁴⁷

abnormal body size | larval stage

lov⁴⁷

abnormal courtship behavior | female

lov^91Y

abnormal courtship behavior | male limited

abnormal courtship behavior | male limited (with Df(2R)Kr10)

abnormal courtship behavior | male limited (with lov³⁸)

lov⁴⁷

abnormal courtship behavior | male limited (with lov⁴⁷)

lov³⁸

abnormal developmental rate | larval stage

lov⁴⁷

abnormal developmental rate | larval stage (with Df(2R)Kr10)

lov⁴⁷

abnormal feeding behavior | larval stage

lov⁴⁷

abnormal gravitaxis

lov^91Y

abnormal locomotor behavior | adult stage

abnormal locomotor behavior | adult stage (with Df(2R)Kr10)

abnormal locomotor behavior | larval stage

lov⁴⁷

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lov^GD4499

flightless, with Scer\GAL4^Mef2.PR

lov^GD4499

short lived (with Df(2R)Kr10)

lov⁴⁷

visible, with Scer\GAL4^pnr-MD237

lov^GD4499

Phenotype manifest in

Allele

dorsal appendage | maternal effect

lov⁶⁶

dorsal appendage | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

lov^UAS.cBa

dorsal appendage | maternal effect (with Df(2R)Kr10)

lov⁶⁶

egg | maternal effect

lov⁶⁶

egg | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

lov^UAS.cBa

egg | maternal effect (with Df(2R)Kr10)

lov⁶⁶

egg chorion | maternal effect

lov⁶⁶

egg chorion | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

lov^UAS.cBa

egg chorion | maternal effect (with Df(2R)Kr10)

lov⁶⁶

mesonotum, with Scer\GAL4^pnr-MD237

lov^GD4499

myofibril, with Scer\GAL4^Mef2.PR

lov^GD4499

sarcomere, with Scer\GAL4^Mef2.PR

lov^GD4499

Z disc, with Scer\GAL4^Mef2.PR

lov^GD4499

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (34)

4 of 14

Yes

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Hsap\PHOSPHO2-KLHL23

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

3 of 14

Yes

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (18)

2 of 14

Yes

Yes

2 of 14

Yes

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

Yes

Xenopus tropicalis (Western clawed frog) (25)

2 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xtro\LOC100496285

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Danio rerio (Zebrafish) (23)

1 of 14

Yes

Yes

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

Drer\LOC108178999

1 of 14

Yes

No

1 of 14

Yes

Yes

1 of 14

Yes

No

1 of 14

Yes

Yes

Caenorhabditis elegans (Nematode, roundworm) (3)

1 of 14

Yes

No

1 of 14

Yes

No

1 of 14

Yes

No

Anopheles gambiae (African malaria mosquito) (40)

Agam\AgaP_AGAP010355

12 of 12

Yes

Yes

Agam\AgaP_AGAP002297

4 of 12

No

Yes

Agam\AgaP_AGAP000080

3 of 12

No

No

Agam\AgaP_AGAP001073

3 of 12

No

No

Agam\AgaP_AGAP001646

3 of 12

No

No

Agam\AgaP_AGAP003189

3 of 12

No

No

Agam\AgaP_AGAP003439

3 of 12

No

No

Agam\AgaP_AGAP003537

3 of 12

No

No

Agam\AgaP_AGAP003685

3 of 12

No

No

Agam\AgaP_AGAP006454

3 of 12

No

No

Agam\AgaP_AGAP008959

3 of 12

No

No

Agam\AgaP_AGAP010063

3 of 12

No

No

Agam\AgaP_AGAP011247

3 of 12

No

No

Agam\AgaP_AGAP011583

3 of 12

No

No

Agam\AgaP_AGAP000585

2 of 12

No

No

Agam\AgaP_AGAP002165

2 of 12

No

No

Agam\AgaP_AGAP002303

2 of 12

No

No

Agam\AgaP_AGAP003286

2 of 12

No

No

Agam\AgaP_AGAP005244

2 of 12

No

No

Agam\AgaP_AGAP005245

2 of 12

No

No

Agam\AgaP_AGAP005747

2 of 12

No

No

Agam\AgaP_AGAP005748

2 of 12

No

No

Agam\AgaP_AGAP006018

2 of 12

No

No

Agam\AgaP_AGAP008031

2 of 12

No

No

Agam\AgaP_AGAP008506

2 of 12

No

Yes

Agam\AgaP_AGAP011902

2 of 12

No

No

Agam\AgaP_AGAP001258

1 of 12

No

Yes

Agam\AgaP_AGAP002163

1 of 12

No

No

Agam\AgaP_AGAP002304

1 of 12

No

Yes

Agam\AgaP_AGAP003428

1 of 12

No

No

Agam\AgaP_AGAP003645

1 of 12

No

No

Agam\AgaP_AGAP005745

1 of 12

No

No

Agam\AgaP_AGAP006457

1 of 12

No

No

Agam\AgaP_AGAP006458

1 of 12

No

No

Agam\AgaP_AGAP008362

1 of 12

No

No

Agam\AgaP_AGAP009641

1 of 12

No

No

Agam\AgaP_AGAP011142

1 of 12

No

No

Agam\AgaP_AGAP012550

1 of 12

No

No

Agam\AgaP_AGAP012669

1 of 12

No

No

Agam\AgaP_AGAP013477

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (1)

1 of 13

Yes

No

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lov. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BTBD18; BTB domain containing 18

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

molecular sieving

(Bonchuk et al., 2024)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

(Bonchuk et al., 2024)

(Hu et al., 2017.6.13)

(Bonchuk et al., 2024)

(Bonchuk et al., 2024)

(Bonchuk et al., 2024)

lov - mod(mdg4)

(Bonchuk et al., 2024)

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266129

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-107

Cytogenetic map

Sequence location

2R:25,085,780..25,139,627 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60F3-60F5

Limits computationally determined from genome sequence between P{EP}CG2790^EP412&P{EP}CG3776^EP835 and P{EP}zip^EP856&P{PZ}l(2)10481⁰³²⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60F-60F

(Laski, 1999.12.22, Laski, 1994.9.5)

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016)

2-111.8

(Comeron et al., 2012)

2-

(Laski, 1994.9.5)

2-107.6

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (55)

Aberrations including deletions of this gene Aberrations including duplications of this gene

3737

w^*; P{GawB}lov^91Y

12912

P{VT022238-GAL4}attP2

12913

P{VT022241-GAL4}attP2

15462

P{VT022223-GAL4}attP2

15522

P{GMR40C04-GAL4}attP2

14486

P{VT022237-lexA}attP2

16357

P{GMR40D05-lexA}JK73A

16377

P{GMR40D05-lexA}JK22C

17366

P{GMR40D05-lexA}attP2

107209

w^*; P{GawB}lov^91Y

v202405

P{VT022237-GAL4}attP2

v10739

w¹¹¹⁸; P{GD4499}v10739

More stocks available...

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH08821

Other clones

DPiM_GH08821

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266129

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhou et al., 2016, Bjorum et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

FBrf0046110 suggested that this may encode a tyrosine protein kinase, but the predicted sequence shows no similarity with any protein kinase.

(Bairoch, 1996.1.26)

Included in genetic and molecular analysis of the zipper-gooseberry region.

(Cote et al., 1987)

The region specific pattern of expression and the putative kinase function are consistent with the suggestion of a regulatory role for this gene during development.

(Haller et al., 1987)

Annotations CG2672, CG16778 merged as CG16778 in release 3 of the genome annotation, April 2002.

No mutant phenotype identified as yet. Transcripts initially expressed in the syncytial blastoderm stage (Halle et al., 1987; Cote et al., 1987), accumulating temporarily at dorsal-lateral positions in the embryo. At the end of blastoderm, the transcripts accumulate unevenly and are restricted to the dorsal region along 20-85% of the egg length. During gastrulation they are found in the dorsal region of the cephalic furrow and cover the neurogenic ectoderm in the procephalic region, disappearing from anterior to posterior during the extended germband stage. Later Tkr is expressed anew in the developing nervous system, including the brain, but disappears completely at the end of embryogenesis (Haller, Cote, Bronner and Jackle, 1987).

Relationship to Other Genes

Source for database merge of

Source for merge of: Tkr BtbIII

(FlyBase, 1996-)

Source for merge of: CG16778 91Y

(Armstrong et al., 2006)

Additional comments

Source for merge of Tkr BtbIII was sequence comparison ( date:000114 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: BtbIII CG2672

(Zhong, 1999.11)

Source for identity of: CG16778 Tkr

(Beckingham et al., 2009.3.18)

Source for identity of: lov CG16778

(Bjorum et al., 2013)

Nomenclature comments

Etymology

The gene is named 'jim lovell' in honor of this astronaut's pioneering work in microgravity.

(Bjorum et al., 2013)

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

091y

(Ejima et al., 2001)

91Y

BTB-III

(Lehmann et al., 1998, Laski, 1994.9.5, Zollman et al., 1994)

BtbIII

CG16778

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Mackowiak et al., 2015, Boyle et al., 2014, Slattery et al., 2014, Saunders et al., 2013, Stagg et al., 2011, Ni et al., 2010.12.1, Perkins et al., 2009, Bjorum and Beckingham, 2008, Bjorum and Beckingham, 2007, Armstrong et al., 2006, Bjorum, 2006)

CG2672

(Manning et al., 2012)

Lov

(El-Danaf et al., 2025, Guan et al., 2022, Bjorum and Beckingham, 2008)

TKR

(Bonchuk et al., 2024, Bonchuk et al., 2011)

Tkr

(Doggett et al., 2011, Jungreis et al., 2011, Herranz et al., 2010, Wheeler et al., 2008, Armstrong et al., 2006, Haynes et al., 2006, Wheeler et al., 2006, Liebl and Featherstone, 2005, Drnevich et al., 2004, Lehmann et al., 1998, Lindsley and Zimm, 1992)

anon-G2

dTKR

(He and Noll, 2013, Duman-Scheel et al., 1997, Haller et al., 1987)

g2

(Cote et al., 1987)

lov

(Zhang et al., 2024, Candia et al., 2023, Kuyateh and Obbard, 2023, Wong et al., 2023, Almeida Machado Costa et al., 2022, Bravo González-Blas et al., 2020, Earl et al., 2020, Zhao et al., 2020, Zhou et al., 2020, Shokri et al., 2019, Tiwari et al., 2019, Croset et al., 2018, Gene Disruption Project members, 2018-, Yamakawa et al., 2018, Hu et al., 2017.6.13, Kahn et al., 2016, Bjorum et al., 2013, Bjorum et al., 2013)

tkr

(Brody et al., 2012, Kearney et al., 2004, Laski, 1999.12.22)

Name Synonyms

91Y

BTB-protein-III

Jim Lovell

(Bjorum and Beckingham, 2008)

Tyrosine kinase related

(Lindsley and Zimm, 1992)

Tyrosine kinase-related

(Armstrong et al., 2006)

Tyrosine kinase-related protein

(Wheeler et al., 2008)

jim lovell

(Bjorum et al., 2013)

Secondary FlyBase IDs

FBgn0067632
FBgn0003715
FBgn0004900
FBgn0012045
FBgn0035093

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38007

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P14083

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P14083

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4LGK1

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P14083

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266129

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38007/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266129

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266129

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16778

MARRVEL_MODEL - MARRVEL (model organism gene)

38007

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266129

DroID - A comprehensive database of gene and protein interactions.

FBgn0266129

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lov_1
lov_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0003715

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266129

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16778

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006481

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (101)