FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\rdx
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General Information
Symbol
Dmel\rdx
Species
D. melanogaster
Name
roadkill
Annotation Symbol
CG12537
Feature Type
protein_coding_gene
FlyBase ID
FBgn0264493
Gene Model Status
Current
Stock Availability
41 publicly available
Gene Summary
roadkill (rdx) encodes a protein that functions as a substrate recognition component of Cul3-based E3 ubiquitin ligase complexes. It regulates the Hedgehog signaling pathway by promoting the degradation of the transcription factor encoded by ci. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

hib, l(3)88Aa, SPOP, l(3)03477, l(3)2004

Key Links
Genomic Location
Cytogenetic map
88A3-88A4
Sequence location
Recombination map
3-54
RefSeq locus
NT_033777 REGION:13967061..14032057
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:P19538
(Zhang et al., 2006)
inferred from physical interaction with UniProtKB:Q9V475
(Zhang et al., 2006)
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Zhang et al., 2009)
enables protein homodimerization activity
inferred from direct assay
(Zhang et al., 2009)
enables ubiquitin-like ligase-substrate adaptor activity
inferred from direct assay
(Zhou et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables ubiquitin protein ligase binding
inferred from biological aspect of ancestor with PANTHER:PTN000698163
(GO Reference Genome Project, 2011-)
Biological Process (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in compound eye morphogenesis
inferred from mutant phenotype
(Kent et al., 2006)
involved_in eye development
inferred from mutant phenotype
(Zhang et al., 2006)
involved_in negative regulation of protein import into nucleus
inferred from mutant phenotype
(Seong et al., 2010)
inferred from genetic interaction with FLYBASE:ci; FB:FBgn0004859
(Seong and Ishii, 2013)
involved_in negative regulation of smoothened signaling pathway
inferred from genetic interaction with FLYBASE:Su(fu); FB:FBgn0005355
(Seong and Ishii, 2013)
inferred from mutant phenotype
(Zhou et al., 2015, Zhou et al., 2015, Zhang et al., 2013, Seong et al., 2010, Kent et al., 2006, Zhang et al., 2006)
inferred from genetic interaction with FLYBASE:ci; FB:FBgn0004859
(Han et al., 2015)
(Shi et al., 2014)
involved_in positive regulation of apoptotic process
inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483
(Liu et al., 2009)
involved_in positive regulation of JNK cascade
inferred from mutant phenotype
(Liu et al., 2009)
involved_in positive regulation of protein catabolic process
inferred from genetic interaction with FLYBASE:ci; FB:FBgn0004859
(Seong and Ishii, 2013)
inferred from mutant phenotype
(Kent et al., 2006)
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from direct assay
(Zhou et al., 2015)
involved_in protein destabilization
inferred from mutant phenotype
(Zhang et al., 2009)
involved_in protein K48-linked ubiquitination
inferred from direct assay
(Zhang et al., 2013)
involved_in protein ubiquitination
inferred from mutant phenotype
(Liu et al., 2009, Zhang et al., 2006)
inferred from direct assay
(Zhou et al., 2015)
involved_in regulation of proteolysis
inferred from mutant phenotype
(Liu et al., 2009)
involved_in segment polarity determination
inferred from mutant phenotype
(Zhang et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000698163
(GO Reference Genome Project, 2011-)
involved_in regulation of proteolysis
inferred from biological aspect of ancestor with PANTHER:PTN000698163
(GO Reference Genome Project, 2011-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
part_of Cul3-RING ubiquitin ligase complex
inferred from direct assay
(Zhou et al., 2015, Zhang et al., 2013)
located_in nucleus
inferred from direct assay
(Zhang et al., 2006)
inferred from direct assay
(Seong et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000698163
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000698511
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the Tdpoz family. (Q9VFP2)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
roadkill (rdx) encodes a protein that functions as a substrate recognition component of Cul3-based E3 ubiquitin ligase complexes. It regulates the Hedgehog signaling pathway by promoting the degradation of the transcription factor encoded by ci. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
NEGATIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Protein Function (UniProtKB)
Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array.
(UniProt, Q9VFP2)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(3)88Aa
Homozygous larvae die in third instar; discs reported as missing, probably rudimentary (see Szabad and Bryant, l982, Dev. Biol. 93: 240-56). Mitotic chromosomes fuzzy and swollen; 27% of cells polyploid; chromosome breaks observed (Gatti and Baker, 1989, Genes Dev. 3: 438-53).
Summary (Interactive Fly)

a member of a conserved family of proteins that serve as substrate adaptors for Cullin3-mediated ubiquitylation - regulates Cubitus interruptus levels by targeting it for degradation

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\rdx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VFP2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

5' UTR contains an ORF described as a putative conserved uORF (FBrf0204849); potential peptide 25aa in length.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
rdx-RA
FBtr0301632
NM_169565
2962
406
rdx-RB
FBtr0301633
NM_169566
2311
374
rdx-RC
FBtr0301634
NM_142068
2802
403
rdx-RE
FBtr0100361
NM_142069
4159
829
rdx-RF
FBtr0334298
NM_169564
3856
406
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
rdx-PA
FBpp0290846
45.8
406
5.93
C7LAF6
NP_731876
AAF55007
rdx-PB
FBpp0290847
42.3
374
5.97
NP_731877
AAN14348
rdx-PC
FBpp0290848
45.3
403
6.32
NP_650325
AAN14346
rdx-PE
FBpp0099767
89.7
829
7.66
Q9VFP2
NP_650326
AAF55008
rdx-PF
FBpp0306413
45.8
406
5.93
C7LAF6
NP_731875
AAN14347
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

406 aa isoforms: rdx-PA, rdx-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with ci and gft/CUL3.

(UniProt, Q9VFP2)
Domain

The MATH domain interacts with ci.

The BTB (POZ) domain interacts with gft/CUL3.

(UniProt, Q9VFP2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rdx using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
anlage in statu nascendi
(Fisher et al., 2012)
central brain anlage in statu nascendi
(Fisher et al., 2012)
ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
primordial germ cell
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
foregut anlage
(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
organism | segmentally repeated
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
embryonic stage 11
ectoderm | segmentally repeated | striped

Comment: two stripes per segment

(Von Ohlen and Hooper, 1999)
visual primordium | restricted
(Biehs et al., 2010)
tracheal pit
(Biehs et al., 2010)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
eye disc posterior to the morphogenetic furrow
(Zhang et al., 2006)
anterior-posterior compartment boundary of the wing disc
(Zhang et al., 2006)
anterior-posterior compartment boundary of the antennal disc
(Zhang et al., 2006)
anterior-posterior compartment boundary of the leg disc
(Zhang et al., 2006)
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
Additional Descriptive Data

rdx is present in both the posterior optic lobe and adjacent anterior optic lobe cells in mid stage 11 embryos. rdx is also expressed in tracheal pits.

(Biehs et al., 2010)

rdx is expressed posterior to the morphogenetic furrow in the eye disc. Expression is elevated near the anterior-posterior compartment boundary of antenna, leg and wing discs.

(Zhang et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of Cul3-RING ubiquitin ligase complex
inferred from direct assay
(Zhou et al., 2015, Zhang et al., 2013)
located_in nucleus
inferred from direct assay
(Zhang et al., 2006)
inferred from direct assay
(Seong et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\rdx in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 86 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of rdx
Transgenic constructs containing regulatory region of rdx
Aberrations (Deficiencies and Duplications) ( 18 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4btl.PS
lethal (with Df(3R)293γ7)
lethal (with rdx1)
lethal (with rdx2)
lethal (with rdx3)
lethal (with rdx4)
lethal (with rdx5)
lethal (with rdx6)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable | germline clone
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal meiotic cell cycle
abnormal mitotic cell cycle
abnormal mitotic cell cycle | germline clone
abnormal size | larval stage
decreased occurrence of cell division | larval stage
flightless, with Scer\GAL4Mef2.PR
some die during embryonic stage
some die during first instar larval stage
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
visible | somatic clone
Phenotype manifest in
Allele
cell cycle
chaeta | increased number, with Scer\GAL4pnr-MD237
embryo | germline clone
eye
imaginal disc
imaginal disc | larval stage
interommatidial bristle
mesonotum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
ommatidial precursor cluster
retina
tormogen cell, with Scer\GAL4pnr-MD237
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4Bx-MS1096
wing | somatic clone
wing vein | ectopic, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (70)
Hsap\SPOP
10 of 14
Yes
Yes
Hsap\SPOPL
9 of 14
No
Yes
1  
Hsap\ABTB1
1 of 14
No
Yes
Hsap\ABTB2
1 of 14
No
No
Hsap\ANKFY1
1 of 14
No
No
Hsap\BTBD1
1 of 14
No
No
Hsap\BTBD2
1 of 14
No
No
Hsap\BTBD3
1 of 14
No
No
Hsap\BTBD6
1 of 14
No
No
Hsap\BTBD8
1 of 14
No
No
Hsap\BTBD9
1 of 14
No
No
Hsap\BTBD11
1 of 14
No
No
Hsap\BTBD18
1 of 14
No
No
Hsap\BTBD19
1 of 14
No
No
Hsap\CCIN
1 of 14
No
No
Hsap\ENC1
1 of 14
No
No
Hsap\GMCL1
1 of 14
No
No
1  
Hsap\GMCL2
1 of 14
No
No
Hsap\IBTK
1 of 14
No
No
Hsap\IPP
1 of 14
No
No
Hsap\KBTBD2
1 of 14
No
No
Hsap\KBTBD3
1 of 14
No
No
Hsap\KBTBD4
1 of 14
No
No
Hsap\KBTBD6
1 of 14
No
No
Hsap\KBTBD7
1 of 14
No
No
Hsap\KBTBD8
1 of 14
No
No
Hsap\KBTBD11
1 of 14
No
No
Hsap\KEAP1
1 of 14
No
No
Hsap\KLHL2
1 of 14
No
No
Hsap\KLHL3
1 of 14
No
No
Hsap\KLHL4
1 of 14
No
No
Hsap\KLHL5
1 of 14
No
No
Hsap\KLHL6
1 of 14
No
No
Hsap\KLHL7
1 of 14
No
No
Hsap\KLHL9
1 of 14
No
No
Hsap\KLHL10
1 of 14
No
No
1  
Hsap\KLHL11
1 of 14
No
No
Hsap\KLHL12
1 of 14
No
No
Hsap\KLHL13
1 of 14
No
No
Hsap\KLHL15
1 of 14
No
No
Hsap\KLHL17
1 of 14
No
No
Hsap\KLHL18
1 of 14
No
No
Hsap\KLHL20
1 of 14
No
No
Hsap\KLHL21
1 of 14
No
No
Hsap\KLHL22
1 of 14
No
No
1  
Hsap\KLHL23
1 of 14
No
No
Hsap\KLHL24
1 of 14
No
No
Hsap\KLHL25
1 of 14
No
No
Hsap\KLHL26
1 of 14
No
No
Hsap\KLHL28
1 of 14
No
No
Hsap\KLHL29
1 of 14
No
No
Hsap\KLHL30
1 of 14
No
No
Hsap\KLHL32
1 of 14
No
No
Hsap\KLHL36
1 of 14
No
No
Hsap\KLHL38
1 of 14
No
No
Hsap\KLHL40
1 of 14
No
No
1  
Hsap\KLHL41
1 of 14
No
No
Hsap\MYNN
1 of 14
No
No
Hsap\PHOSPHO2-KLHL23
1 of 14
No
No
Hsap\RCBTB1
1 of 14
No
No
Hsap\RCBTB2
1 of 14
No
No
Hsap\RHOBTB3
1 of 14
No
No
Hsap\ZBTB6
1 of 14
No
No
Hsap\ZBTB11
1 of 14
No
No
Hsap\ZBTB14
1 of 14
No
No
Hsap\ZBTB21
1 of 14
No
No
Hsap\ZBTB24
1 of 14
No
No
1  
Hsap\ZBTB44
1 of 14
No
No
Hsap\ZNF131
1 of 14
No
No
Hsap\ZNF524
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (63)
Rnor\Spop
10 of 14
Yes
Yes
Rnor\Spopl
9 of 14
No
Yes
Rnor\LOC100911679
5 of 14
No
Yes
Rnor\RGD1560510
5 of 14
No
Yes
Rnor\RGD1563667
5 of 14
No
Yes
Rnor\RGD1564313
5 of 14
No
Yes
Rnor\RGD1566337
5 of 14
No
Yes
Rnor\LOC689173
4 of 14
No
Yes
Rnor\RGD1560554
4 of 14
No
Yes
Rnor\RGD1559714
3 of 14
No
Yes
Rnor\Klhl17
2 of 14
No
No
Rnor\Abtb1
1 of 14
No
Yes
Rnor\Abtb2
1 of 14
No
No
Rnor\Btbd1
1 of 14
No
No
Rnor\Btbd2
1 of 14
No
No
Rnor\Btbd3
1 of 14
No
No
Rnor\Btbd6
1 of 14
No
No
Rnor\Btbd9
1 of 14
No
No
Rnor\Btbd19
1 of 14
No
No
Rnor\Ccin
1 of 14
No
No
Rnor\Enc1
1 of 14
No
No
Rnor\Gmcl1
1 of 14
No
No
Rnor\Ibtk
1 of 14
No
No
Rnor\Ipp
1 of 14
No
No
Rnor\Ivns1abp
1 of 14
No
No
Rnor\Kbtbd2
1 of 14
No
No
Rnor\Kbtbd3
1 of 14
No
No
Rnor\Kbtbd4
1 of 14
No
No
Rnor\Kbtbd8
1 of 14
No
No
Rnor\Kbtbd11
1 of 14
No
Yes
Rnor\Keap1
1 of 14
No
No
Rnor\Klhl2
1 of 14
No
No
Rnor\Klhl6
1 of 14
No
No
Rnor\Klhl7
1 of 14
No
No
Rnor\Klhl9
1 of 14
No
No
Rnor\Klhl12
1 of 14
No
No
Rnor\Klhl13
1 of 14
No
No
Rnor\Klhl15
1 of 14
No
No
Rnor\Klhl20
1 of 14
No
No
Rnor\Klhl21
1 of 14
No
No
Rnor\Klhl22
1 of 14
No
No
Rnor\Klhl23
1 of 14
No
No
Rnor\Klhl24
1 of 14
No
No
Rnor\Klhl25
1 of 14
No
No
Rnor\Klhl26
1 of 14
No
No
Rnor\Klhl28
1 of 14
No
No
Rnor\Klhl29
1 of 14
No
No
Rnor\Klhl30
1 of 14
No
No
Rnor\Klhl34
1 of 14
No
No
Rnor\Klhl36
1 of 14
No
No
Rnor\Klhl38
1 of 14
No
No
Rnor\LOC100911153
1 of 14
No
Yes
Rnor\LOC102553503
1 of 14
No
Yes
Rnor\Lztr1
1 of 14
No
No
Rnor\Rcbtb1
1 of 14
No
No
Rnor\Rcbtb2
1 of 14
No
No
Rnor\RGD1560661
1 of 14
No
Yes
Rnor\RGD1563451
1 of 14
No
Yes
Rnor\RGD1564513
1 of 14
No
Yes
Rnor\RGD1565369
1 of 14
No
Yes
Rnor\Rhobtb3
1 of 14
No
No
Rnor\Tdpoz1
1 of 14
No
Yes
Rnor\Zbtb16
1 of 14
No
No
Mus musculus (laboratory mouse) (63)
Mmus\Spop
10 of 14
Yes
Yes
 
9  
Mmus\Spopl
8 of 14
No
Yes
Mmus\Spopfm2
6 of 14
No
Yes
Mmus\Tdpoz1
6 of 14
No
Yes
Mmus\Tdpoz3
6 of 14
No
Yes
Mmus\Tdpoz4
6 of 14
No
Yes
Mmus\Tdpoz9
6 of 14
No
Yes
Mmus\Tdpoz2
5 of 14
No
Yes
Mmus\Tdpoz5
5 of 14
No
Yes
Mmus\Tdpoz8
5 of 14
No
Yes
Mmus\Gm5773
4 of 14
No
Yes
Mmus\Spopfm1
4 of 14
No
Yes
Mmus\Spopfm3
4 of 14
No
Yes
Mmus\Tdpoz6
4 of 14
No
Yes
Mmus\Tdpoz9-ps1
3 of 14
No
Yes
Mmus\Abtb1
1 of 14
No
Yes
Mmus\Abtb2
1 of 14
No
No
Mmus\Btbd1
1 of 14
No
No
Mmus\Btbd2
1 of 14
No
No
Mmus\Btbd3
1 of 14
No
No
Mmus\Btbd6
1 of 14
No
No
Mmus\Btbd8
1 of 14
No
No
Mmus\Btbd9
1 of 14
No
No
Mmus\Btbd11
1 of 14
No
No
Mmus\Btbd19
1 of 14
No
No
Mmus\Ccin
1 of 14
No
No
Mmus\Enc1
1 of 14
No
No
Mmus\Gmcl1
1 of 14
No
No
Mmus\Ibtk
1 of 14
No
No
Mmus\Ipp
1 of 14
No
No
Mmus\Ivns1abp
1 of 14
No
No
Mmus\Kbtbd2
1 of 14
No
No
Mmus\Kbtbd3
1 of 14
No
No
Mmus\Kbtbd4
1 of 14
No
No
Mmus\Kbtbd8
1 of 14
No
No
Mmus\Kbtbd11
1 of 14
No
Yes
Mmus\Keap1
1 of 14
No
No
Mmus\Klhl2
1 of 14
No
No
Mmus\Klhl6
1 of 14
No
No
Mmus\Klhl7
1 of 14
No
No
Mmus\Klhl9
1 of 14
No
No
Mmus\Klhl12
1 of 14
No
No
Mmus\Klhl13
1 of 14
No
No
Mmus\Klhl15
1 of 14
No
No
Mmus\Klhl17
1 of 14
No
No
Mmus\Klhl18
1 of 14
No
No
Mmus\Klhl20
1 of 14
No
No
Mmus\Klhl21
1 of 14
No
No
Mmus\Klhl22
1 of 14
No
No
Mmus\Klhl23
1 of 14
No
No
Mmus\Klhl24
1 of 14
No
No
Mmus\Klhl25
1 of 14
No
No
Mmus\Klhl26
1 of 14
No
No
Mmus\Klhl28
1 of 14
No
No
Mmus\Klhl29
1 of 14
No
No
Mmus\Klhl30
1 of 14
No
No
Mmus\Klhl36
1 of 14
No
No
Mmus\Lztr1
1 of 14
No
No
Mmus\Rcbtb1
1 of 14
No
No
Mmus\Rcbtb2
1 of 14
No
No
Mmus\Rhobtb3
1 of 14
No
No
Mmus\Tdpoz7
1 of 14
No
Yes
Mmus\Zbtb16
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (47)
Xtro\spop
8 of 13
Yes
Yes
Xtro\spopl
6 of 13
No
Yes
Xtro\abtb1
1 of 13
No
No
Xtro\btbd3
1 of 13
No
No
Xtro\btbd8
1 of 13
No
No
Xtro\btbd18
1 of 13
No
No
Xtro\cdkl5
1 of 13
No
No
Xtro\crebbp
1 of 13
No
No
Xtro\enc1.2
1 of 13
No
No
Xtro\enc1
1 of 13
No
No
Xtro\fam53a
1 of 13
No
No
Xtro\gmcl1
1 of 13
No
No
Xtro\guca1al
1 of 13
No
No
Xtro\ibtk
1 of 13
No
No
Xtro\ifngr1
1 of 13
No
No
Xtro\kbtbd2
1 of 13
No
No
Xtro\kbtbd3
1 of 13
No
No
Xtro\kbtbd8
1 of 13
No
No
Xtro\kbtbd12
1 of 13
No
No
Xtro\klhl2
1 of 13
No
No
Xtro\klhl5
1 of 13
No
No
Xtro\klhl6
1 of 13
No
No
Xtro\klhl7
1 of 13
No
No
Xtro\klhl14
1 of 13
No
No
Xtro\klhl17
1 of 13
No
No
Xtro\klhl21
1 of 13
No
No
Xtro\klhl22
1 of 13
No
No
Xtro\klhl23
1 of 13
No
No
Xtro\klhl24
1 of 13
No
No
Xtro\klhl25
1 of 13
No
No
Xtro\klhl28
1 of 13
No
No
Xtro\klhl29
1 of 13
No
No
Xtro\klhl31
1 of 13
No
No
Xtro\klhl36
1 of 13
No
No
Xtro\klhl38
1 of 13
No
No
Xtro\klhl40
1 of 13
No
No
Xtro\LOC100496285
1 of 13
No
No
Xtro\lztr1
1 of 13
No
No
Xtro\mthfd2
1 of 13
No
No
Xtro\phf5a
1 of 13
No
No
Xtro\plekhn1
1 of 13
No
No
Xtro\rhobtb2
1 of 13
No
No
Xtro\zbtb6
1 of 13
No
Yes
Xtro\zbtb14
1 of 13
No
Yes
Xtro\zbtb41
1 of 13
No
No
Xtro\zbtb43
1 of 13
No
No
Xtro\zbtb44
1 of 13
No
Yes
Danio rerio (Zebrafish) (62)
Drer\spop
9 of 14
Yes
Yes
Drer\spoplb
9 of 14
Yes
Yes
Drer\spopla
8 of 14
No
Yes
Drer\abtb1
1 of 14
No
Yes
Drer\abtb2a
1 of 14
No
No
Drer\btbd2a
1 of 14
No
No
Drer\btbd3a
1 of 14
No
No
Drer\btbd3b
1 of 14
No
No
Drer\btbd6a
1 of 14
No
No
Drer\btbd6b
1 of 14
No
No
Drer\btbd8
1 of 14
No
No
Drer\btbd9
1 of 14
No
No
Drer\crebbpb
1 of 14
No
No
Drer\enc1
1 of 14
No
No
Drer\enc2
1 of 14
No
No
Drer\enc3
1 of 14
No
No
Drer\ep300a
1 of 14
No
No
Drer\fem1a
1 of 14
No
No
Drer\gmcl1
1 of 14
No
No
Drer\ibtk
1 of 14
No
No
Drer\ivns1abpb
1 of 14
No
No
Drer\kbtbd2
1 of 14
No
No
Drer\kbtbd3
1 of 14
No
No
Drer\kbtbd4
1 of 14
No
No
Drer\kbtbd8
1 of 14
No
No
Drer\kbtbd11
1 of 14
No
Yes
Drer\keap1b
1 of 14
No
No
Drer\klhl3
1 of 14
No
No
Drer\klhl6
1 of 14
No
No
Drer\klhl7
1 of 14
No
No
Drer\klhl10a
1 of 14
No
No
Drer\klhl12
1 of 14
No
No
Drer\klhl13
1 of 14
No
No
Drer\klhl15
1 of 14
No
No
Drer\klhl17
1 of 14
No
No
Drer\klhl18
1 of 14
No
No
Drer\klhl20
1 of 14
No
No
Drer\klhl21
1 of 14
No
No
Drer\klhl22
1 of 14
No
No
Drer\klhl23
1 of 14
No
No
Drer\klhl24a
1 of 14
No
No
Drer\klhl24b
1 of 14
No
No
Drer\klhl25
1 of 14
No
No
Drer\klhl26
1 of 14
No
No
Drer\klhl30
1 of 14
No
No
Drer\klhl32
1 of 14
No
No
Drer\klhl35
1 of 14
No
No
Drer\klhl36
1 of 14
No
No
Drer\klhl38a
1 of 14
No
No
Drer\klhl40a
1 of 14
No
No
Drer\klhl40b
1 of 14
No
No
Drer\klhl41a
1 of 14
No
No
Drer\klhl41b
1 of 14
No
No
Drer\klhl42
1 of 14
No
Yes
Drer\LOC555499
1 of 14
No
No
Drer\LOC101883073
1 of 14
No
Yes
Drer\LOC108178999
1 of 14
No
No
Drer\lztr1
1 of 14
No
No
Drer\rcbtb1
1 of 14
No
No
Drer\rhobtb3
1 of 14
No
No
Drer\si:ch211-63p21.8
1 of 14
No
No
Drer\si:dkey-260j18.2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (117)
Cele\spop-1
9 of 14
Yes
Yes
Cele\mel-26
5 of 14
No
Yes
Cele\bath-40
4 of 14
No
Yes
Cele\bath-41
4 of 14
No
Yes
Cele\bath-42
4 of 14
No
Yes
Cele\bath-44
3 of 14
No
Yes
Cele\bath-3
2 of 14
No
Yes
Cele\bath-10
2 of 14
No
Yes
Cele\bath-13
2 of 14
No
Yes
Cele\bath-19
2 of 14
No
Yes
Cele\bath-20
2 of 14
No
Yes
Cele\bath-21
2 of 14
No
Yes
Cele\bath-25
2 of 14
No
Yes
Cele\bath-26
2 of 14
No
Yes
Cele\bath-30
2 of 14
No
Yes
Cele\bath-34
2 of 14
No
Yes
Cele\bath-46
2 of 14
No
Yes
Cele\K05F6.10
2 of 14
No
Yes
Cele\math-1
2 of 14
No
Yes
Cele\math-34
2 of 14
No
Yes
Cele\sdz-28
2 of 14
No
Yes
Cele\Y49F6C.2
2 of 14
No
Yes
Cele\bath-1
1 of 14
No
Yes
Cele\bath-2
1 of 14
No
Yes
Cele\bath-4
1 of 14
No
Yes
Cele\bath-5
1 of 14
No
Yes
Cele\bath-7
1 of 14
No
Yes
Cele\bath-9
1 of 14
No
Yes
Cele\bath-15
1 of 14
No
Yes
Cele\bath-23
1 of 14
No
No
Cele\bath-24
1 of 14
No
Yes
Cele\bath-27
1 of 14
No
Yes
Cele\bath-29
1 of 14
No
Yes
Cele\bath-31
1 of 14
No
Yes
Cele\bath-33
1 of 14
No
Yes
Cele\bath-35
1 of 14
No
Yes
Cele\bath-36
1 of 14
No
Yes
Cele\bath-38
1 of 14
No
Yes
Cele\bath-39
1 of 14
No
Yes
Cele\bath-45
1 of 14
No
Yes
Cele\bath-47
1 of 14
No
Yes
Cele\btb-2
1 of 14
No
Yes
Cele\btb-4
1 of 14
No
Yes
Cele\btb-5
1 of 14
No
Yes
Cele\btb-6
1 of 14
No
Yes
Cele\btb-7
1 of 14
No
Yes
Cele\btb-8
1 of 14
No
Yes
Cele\btb-9
1 of 14
No
Yes
Cele\btb-10
1 of 14
No
Yes
Cele\btb-11
1 of 14
No
Yes
Cele\btb-12
1 of 14
No
Yes
Cele\btb-14
1 of 14
No
Yes
Cele\btb-16
1 of 14
No
Yes
Cele\btb-17
1 of 14
No
Yes
Cele\btb-18
1 of 14
No
Yes
Cele\btb-19
1 of 14
No
Yes
Cele\btb-20
1 of 14
No
Yes
Cele\btb-22
1 of 14
No
Yes
Cele\C15H9.2
1 of 14
No
Yes
Cele\eor-1
1 of 14
No
No
Cele\F14D2.15
1 of 14
No
Yes
Cele\F25H9.2
1 of 14
No
Yes
Cele\F45C12.9
1 of 14
No
Yes
Cele\H31G24.3
1 of 14
No
Yes
Cele\hpo-9
1 of 14
No
No
Cele\K08E4.7
1 of 14
No
Yes
Cele\kel-1
1 of 14
No
No
Cele\kel-3
1 of 14
No
No
Cele\kel-8
1 of 14
No
No
Cele\kel-10
1 of 14
No
No
Cele\kel-20
1 of 14
No
No
Cele\math-3
1 of 14
No
Yes
Cele\math-4
1 of 14
No
Yes
Cele\math-5
1 of 14
No
Yes
Cele\math-6
1 of 14
No
Yes
Cele\math-7
1 of 14
No
Yes
Cele\math-8
1 of 14
No
Yes
Cele\math-9
1 of 14
No
Yes
Cele\math-10
1 of 14
No
Yes
Cele\math-13
1 of 14
No
Yes
Cele\math-14
1 of 14
No
Yes
Cele\math-15
1 of 14
No
Yes
Cele\math-16
1 of 14
No
Yes
Cele\math-18
1 of 14
No
Yes
Cele\math-19
1 of 14
No
Yes
Cele\math-20
1 of 14
No
Yes
Cele\math-21
1 of 14
No
Yes
Cele\math-22
1 of 14
No
Yes
Cele\math-23
1 of 14
No
Yes
Cele\math-24
1 of 14
No
Yes
Cele\math-25
1 of 14
No
Yes
Cele\math-26
1 of 14
No
Yes
Cele\math-28
1 of 14
No
Yes
Cele\math-29
1 of 14
No
Yes
Cele\math-31
1 of 14
No
Yes
Cele\math-37
1 of 14
No
Yes
Cele\math-38
1 of 14
No
Yes
Cele\math-39
1 of 14
No
Yes
Cele\math-40
1 of 14
No
Yes
Cele\math-41
1 of 14
No
Yes
Cele\math-42
1 of 14
No
Yes
Cele\math-44
1 of 14
No
Yes
Cele\math-45
1 of 14
No
Yes
Cele\math-48
1 of 14
No
Yes
Cele\math-49
1 of 14
No
Yes
Cele\R10E4.1
1 of 14
No
Yes
Cele\sdz-18
1 of 14
No
Yes
Cele\tag-30
1 of 14
No
No
Cele\W07A12.4
1 of 14
No
No
Cele\Y16E11A.4
1 of 14
No
Yes
Cele\Y43E12A.3
1 of 14
No
Yes
Cele\Y43F8C.3
1 of 14
No
Yes
Cele\Y54F10AM.11
1 of 14
No
Yes
Cele\Y59E9AL.8
1 of 14
No
Yes
Cele\Y97E10AR.1
1 of 14
No
Yes
Cele\Y108F1.5
1 of 14
No
No
Cele\ZK250.14
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (51)
Agam\AgaP_AGAP003428
8 of 12
Yes
Yes
Agam\AgaP_AGAP000233
2 of 12
No
No
Agam\AgaP_AGAP003645
2 of 12
No
No
Agam\AgaP_AGAP006690
2 of 12
No
No
Agam\AgaP_AGAP006697
2 of 12
No
Yes
Agam\AgaP_AGAP006870
2 of 12
No
No
Agam\AgaP_AGAP008362
2 of 12
No
No
Agam\AgaP_AGAP008739
2 of 12
No
No
Agam\AgaP_AGAP009641
2 of 12
No
No
Agam\AgaP_AGAP009913
2 of 12
No
No
Agam\KLHDB_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP000080
1 of 12
No
No
Agam\AgaP_AGAP000475
1 of 12
No
No
Agam\AgaP_AGAP000585
1 of 12
No
No
Agam\AgaP_AGAP001073
1 of 12
No
No
Agam\AgaP_AGAP001258
1 of 12
No
Yes
Agam\AgaP_AGAP001513
1 of 12
No
No
Agam\AgaP_AGAP001646
1 of 12
No
No
Agam\AgaP_AGAP002165
1 of 12
No
No
Agam\AgaP_AGAP002303
1 of 12
No
No
Agam\AgaP_AGAP003189
1 of 12
No
No
Agam\AgaP_AGAP003286
1 of 12
No
No
Agam\AgaP_AGAP003439
1 of 12
No
No
Agam\AgaP_AGAP003537
1 of 12
No
No
Agam\AgaP_AGAP003685
1 of 12
No
No
Agam\AgaP_AGAP003823
1 of 12
No
No
Agam\AgaP_AGAP004234
1 of 12
No
No
Agam\AgaP_AGAP004292
1 of 12
No
No
Agam\AgaP_AGAP005244
1 of 12
No
No
Agam\AgaP_AGAP005245
1 of 12
No
No
Agam\AgaP_AGAP005747
1 of 12
No
No
Agam\AgaP_AGAP006018
1 of 12
No
No
Agam\AgaP_AGAP006454
1 of 12
No
No
Agam\AgaP_AGAP006474
1 of 12
No
No
Agam\AgaP_AGAP006689
1 of 12
No
No
Agam\AgaP_AGAP006712
1 of 12
No
No
Agam\AgaP_AGAP006714
1 of 12
No
No
Agam\AgaP_AGAP006785
1 of 12
No
No
Agam\AgaP_AGAP008031
1 of 12
No
No
Agam\AgaP_AGAP008506
1 of 12
No
No
Agam\AgaP_AGAP009939
1 of 12
No
No
Agam\AgaP_AGAP010063
1 of 12
No
No
Agam\AgaP_AGAP010355
1 of 12
No
No
Agam\AgaP_AGAP010439
1 of 12
No
No
Agam\AgaP_AGAP011142
1 of 12
No
No
Agam\AgaP_AGAP011247
1 of 12
No
No
Agam\AgaP_AGAP011583
1 of 12
No
No
Agam\AgaP_AGAP011728
1 of 12
No
No
Agam\AgaP_AGAP011902
1 of 12
No
No
Agam\AgaP_AGAP012255
1 of 12
No
No
Agam\AgaP_AGAP012550
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (105)
Atha\BPM4
8 of 13
Yes
Yes
Atha\BPM1
7 of 13
No
Yes
Atha\BPM2
7 of 13
No
Yes
Atha\BPM3
7 of 13
No
Yes
Atha\BPM5
6 of 13
No
Yes
Atha\BPM6
6 of 13
No
Yes
Atha\AT1G21780
4 of 13
No
Yes
Atha\AT1G55760
4 of 13
No
Yes
Atha\AT4G08455
4 of 13
No
Yes
Atha\ABAP1
2 of 13
No
No
Atha\ARIA
2 of 13
No
No
Atha\AT1G01640
2 of 13
No
Yes
Atha\AT2G05330
2 of 13
No
Yes
Atha\AT2G40440
2 of 13
No
Yes
Atha\AT2G40450
2 of 13
No
Yes
Atha\AT3G29740
2 of 13
No
Yes
Atha\AT3G56230
2 of 13
No
Yes
Atha\AT4G04090
2 of 13
No
Yes
Atha\AT5G48510
2 of 13
No
Yes
Atha\AT1G31370
1 of 13
No
Yes
Atha\AT1G31380
1 of 13
No
Yes
Atha\AT1G31390
1 of 13
No
Yes
Atha\AT1G31400
1 of 13
No
Yes
Atha\AT1G65050
1 of 13
No
Yes
Atha\AT1G65150
1 of 13
No
Yes
Atha\AT1G65370
1 of 13
No
Yes
Atha\AT1G69650
1 of 13
No
Yes
Atha\AT1G69660
1 of 13
No
Yes
Atha\AT2G01790
1 of 13
No
Yes
Atha\AT2G04170
1 of 13
No
Yes
Atha\AT2G04190
1 of 13
No
Yes
Atha\AT2G04740
1 of 13
No
Yes
Atha\AT2G05400
1 of 13
No
Yes
Atha\AT2G05410
1 of 13
No
Yes
Atha\AT2G05420
1 of 13
No
Yes
Atha\AT2G05430
1 of 13
No
Yes
Atha\AT2G15710
1 of 13
No
Yes
Atha\AT2G25320
1 of 13
No
Yes
Atha\AT2G25330
1 of 13
No
No
Atha\AT2G30600
1 of 13
No
No
Atha\AT2G32870
1 of 13
No
Yes
Atha\AT2G32880
1 of 13
No
Yes
Atha\AT2G42460
1 of 13
No
Yes
Atha\AT2G42470
1 of 13
No
Yes
Atha\AT2G42480
1 of 13
No
Yes
Atha\AT3G17380
1 of 13
No
Yes
Atha\AT3G20360
1 of 13
No
Yes
Atha\AT3G20370
1 of 13
No
Yes
Atha\AT3G20380
1 of 13
No
Yes
Atha\AT3G22080
1 of 13
No
Yes
Atha\AT3G27040
1 of 13
No
Yes
Atha\AT3G28220
1 of 13
No
Yes
Atha\AT3G29580
1 of 13
No
Yes
Atha\AT3G44790
1 of 13
No
Yes
Atha\AT3G44800
1 of 13
No
Yes
Atha\AT3G44805
1 of 13
No
Yes
Atha\AT3G46190
1 of 13
No
Yes
Atha\AT3G58200
1 of 13
No
Yes
Atha\AT3G58210
1 of 13
No
Yes
Atha\AT3G58220
1 of 13
No
Yes
Atha\AT3G58230
1 of 13
No
Yes
Atha\AT3G58240
1 of 13
No
Yes
Atha\AT3G58250
1 of 13
No
Yes
Atha\AT3G58260
1 of 13
No
Yes
Atha\AT3G58270
1 of 13
No
Yes
Atha\AT3G58280
1 of 13
No
Yes
Atha\AT3G58290
1 of 13
No
Yes
Atha\AT3G58300
1 of 13
No
Yes
Atha\AT3G58320
1 of 13
No
Yes
Atha\AT3G58330
1 of 13
No
Yes
Atha\AT3G58340
1 of 13
No
Yes
Atha\AT3G58360
1 of 13
No
Yes
Atha\AT3G58370
1 of 13
No
Yes
Atha\AT3G58380
1 of 13
No
Yes
Atha\AT3G58400
1 of 13
No
Yes
Atha\AT3G58410
1 of 13
No
Yes
Atha\AT3G58420
1 of 13
No
Yes
Atha\AT3G58430
1 of 13
No
Yes
Atha\AT3G58440
1 of 13
No
Yes
Atha\AT4G00780
1 of 13
No
Yes
Atha\AT4G01390
1 of 13
No
Yes
Atha\AT4G09770
1 of 13
No
Yes
Atha\AT4G09780
1 of 13
No
Yes
Atha\AT4G26120
1 of 13
No
Yes
Atha\AT5G03550
1 of 13
No
Yes
Atha\AT5G12850
1 of 13
No
No
Atha\AT5G26260
1 of 13
No
Yes
Atha\AT5G26280
1 of 13
No
Yes
Atha\AT5G26290
1 of 13
No
Yes
Atha\AT5G26300
1 of 13
No
Yes
Atha\AT5G26320
1 of 13
No
Yes
Atha\BOP1
1 of 13
No
Yes
Atha\BOP2
1 of 13
No
Yes
Atha\BT2
1 of 13
No
Yes
Atha\BT3
1 of 13
No
No
Atha\BT4
1 of 13
No
Yes
Atha\BT5
1 of 13
No
Yes
Atha\HAC1
1 of 13
No
No
Atha\HAC12
1 of 13
No
No
Atha\NPR1
1 of 13
No
Yes
Atha\NPR3
1 of 13
No
Yes
Atha\NPR4
1 of 13
No
Yes
Atha\POB1
1 of 13
No
No
Atha\RTM3
1 of 13
No
Yes
Atha\ZW9
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\YIL001W
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\btb3
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:rdx. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (47)
CG7058
3 of 13
CG11275
3 of 13
CG15097
2 of 13
ab
1 of 13
bab1
1 of 13
bab2
1 of 13
br
1 of 13
BTBD9
1 of 13
BtbVII
1 of 13
CG1812
1 of 13
CG6118
1 of 13
CG6765
1 of 13
CG7102
1 of 13
CG8924
1 of 13
CG9426
1 of 13
CG11714
1 of 13
CG12236
1 of 13
CG14262
1 of 13
CG15812
1 of 13
CG17068
1 of 13
CG17754
1 of 13
CG30431
1 of 13
CG34376
1 of 13
CG43120
1 of 13
CG43980
1 of 13
chinmo
1 of 13
dbo
1 of 13
fru
1 of 13
gprs
1 of 13
Keap1
1 of 13
kel
1 of 13
ken
1 of 13
KLHL18
1 of 13
lolal
1 of 13
lola
1 of 13
lov
1 of 13
lute
1 of 13
mamo
1 of 13
mod(mdg4)
1 of 13
psq
1 of 13
RhoBTB
1 of 13
rib
1 of 13
Rnb
1 of 13
tono
1 of 13
Trl
1 of 13
ttk
1 of 13
Usp7
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
rdxNIG.9924R
model of  cancer
CEA with ci-3P.UAS.W.Tag:HA
(Gao et al., 2023)
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SPOP; speckle type BTB/POZ protein
10 of 14
602650
    SPOPL; speckle type BTB/POZ protein like
    9 of 14
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Dmel gene
        Ortholog showing functional complementation
        Supporting References
        rdx
        Mmus\Spop
        (Gao et al., 2023)
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        rdx
        anti tag coimmunoprecipitation, anti tag western blot
        (Zhou et al., 2015, Zhang et al., 2009)
        rdx - CG14074
        two hybrid
        (Hu et al., 2017.6.13)
        rdx - CG8833
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        rdx - COX5B
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        rdx - Cand1
        pull down, western blot
        (Kim et al., 2010)
        rdx - Cul3
        anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, autoradiography, western blot
        (Zhou et al., 2015, Zhang et al., 2013, Kim et al., 2010, Arama et al., 2007, Zhang et al., 2006)
        rdx - Diap1
        anti tag coimmunoprecipitation, anti tag western blot
        (Liu et al., 2021)
        rdx - Pc
        pull down, peptide massfingerprinting
        (Strübbe et al., 2011)
        rdx - RanBP3
        two hybrid
        (Hu et al., 2017.6.13)
        rdx - Ubi-p5E
        anti tag coimmunoprecipitation, anti tag western blot
        (Zhou et al., 2015)
        rdx - Ubi-p63E
        anti tag coimmunoprecipitation, anti tag western blot
        (Zhou et al., 2015)
        rdx - cal1
        two hybrid, anti tag coimmunoprecipitation, western blot
        (Bade et al., 2014)
        rdx - ci
        two hybrid, pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, peptide massfingerprinting
        (Han et al., 2019, Zhou et al., 2015, Liu et al., 2014, Shi et al., 2014, Zhang et al., 2013, Seong et al., 2010, Zhang et al., 2009, Kent et al., 2006, Zhang et al., 2006)
        rdx - lwr
        two hybrid
        (Hu et al., 2017.6.13)
        rdx - puc
        anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot
        (Liu et al., 2009, Zhang et al., 2009, Zhuang et al., 2009)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        ci|rdx
        suppressible
        grim
        (Gao et al., 2023)
        ci|rdx
        suppressible
        hid
        (Gao et al., 2023)
        rdx
        suppressible
        Polr2C
        (Gao et al., 2023)
        ci|rdx
        suppressible
        Polr2C
        (Gao et al., 2023)
        ci|rdx
        suppressible
        Polr2G
        (Gao et al., 2023)
        rdx
        suppressible
        Polr2G
        (Gao et al., 2023)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        ci
        enhanceable
        rdx
        (Zhang et al., 2006)
        grim
        suppressible
        rdx
        (Gao et al., 2023)
        grim
        suppressible
        ci|rdx
        (Gao et al., 2023)
        Pc
        suppressible
        rdx
        (Strübbe et al., 2011)
        rpr
        suppressible
        ci|rdx
        (Gao et al., 2023)
        External Data
        Subunit Structure (UniProtKB)
        Interacts with ci and gft/CUL3.
        (UniProt, Q9VFP2 )
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-54
        Cytogenetic map
        88A3-88A4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        88A3-88A4
        Limits computationally determined from genome sequence between P{PZ}flfl01949 and P{lacW}trxj14A6&P{PZ}trx00347
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        88A-88B
        (determined by in situ hybridisation)
        (Lukacsovich et al., 2001)
        88A4-88A5
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        88A1-88A2
        (determined by in situ hybridisation)
        (Szeged Stock Center, 1998-, Deak et al., 1997)
        88A-88A
        (Sekelsky et al., 1999)
        66B10-66B11
        82A3--5
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        3-54

        (FlyBase, 2016)

        3-52.0

        (Comeron et al., 2012)

        3-50.3

        (Gatti and Baker, 1989)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (41)
        Genomic Clones (42)
        cDNA Clones (122)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Host gene for maternally inherited stable intronic sequence RNA (sisRNA).

            (Tay and Pek, 2017)

            rdx is expressed in response to hh.

            (Kent et al., 2006)

            Area matching Drosophila EST AA696584 (inverted).

            (Davies, 2001.3.15)

            Identification: In a genetic screen for meiotic mutants.

            (Sekelsky et al., 1999)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: rdx mei-P19

            (Seong et al., 2010)

            Source for merge of: l(3)dsl6 l(3)SG40

            (Shearn, 1995.5.3)

            Source for merge of: l(3)88Aa l(3)03477

            (Jarman and Collett, 1998)

            Source for merge of: CG12537 anon-WO0118547.577

            (FlyBase Genome Annotators, 2005, FlyBase, 1996-)

            Source for merge of: rdx CG9924

            (Wang, 2007.3.16)

            Source for merge of: CG9924 BEST:GM07940

            (Rana, 2004.7.8)

            Source for merge of: rdx l(3)S086909

            (Link et al., 2007)
            Additional comments

            Source for merge of CG12537 anon-WO0118547.577 was sequence comparison ( date:051113 ).

            (FlyBase Genome Annotators, 2005, FlyBase, 1996-)
            Nomenclature History
            Source for database identify of

            Source for identity of: rdx CG9924

            (Kent et al., 2006)
            Nomenclature comments
            Etymology

            One allele generates embryos with mitotic defects that often fail to completely cellularize, hence, the name "roadkill".

            (Kent et al., 2004)
            Synonyms and Secondary IDs (34)
            Reported As
            Symbol Synonym
            0869/09
            (Deak et al., 1997)
            BEST:GM07940
            CG10235
            (Kent et al., 2006)
            CG12537
            (Hosono et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, González et al., 2008, Lim et al., 2004, Giot et al., 2003)
            CG9924
            (Jayanandanan et al., 2011, Seong et al., 2010, Liu et al., 2009, Hayden and Bosco, 2008, Arama et al., 2007, Buszczak et al., 2007, Li et al., 2007, Link et al., 2007, Quinones-Coello, 2007, Wang, 2007.3.16, Kent et al., 2006, Molnar et al., 2006, Zhang et al., 2006, Grad et al., 2004)
            D-SPOP
            (Liu et al., 2009)
            Dromel_CG9924_FBtr0082871_rdx_mORF
            (Hayden and Bosco, 2008)
            HIB
            (Umberger and Ogden, 2021, Zhang and Jiang, 2021, Han et al., 2019, Han et al., 2015, Xiong et al., 2015, Shi et al., 2014, Chen and Jiang, 2013, Jia et al., 2010, Kim et al., 2010, Zhuang et al., 2009)
            Hib
            (Zhou et al., 2015)
            Rdx
            (Pan et al., 2017, Chen and Jiang, 2013, Zhang et al., 2013, Zhang et al., 2013, Strübbe et al., 2011, Hayden and Bosco, 2008)
            SPOP
            (Umberger and Ogden, 2021, Zhang et al., 2009, Zhuang et al., 2009)
            Spop
            (Arama et al., 2007)
            anon-WO0118547.577
            hib
            (Gao et al., 2023, Zhou et al., 2015, Liu et al., 2014, Chen and Jiang, 2013, Zhang et al., 2009, Huang et al., 2008, Chien-Hsiang et al., 2007, Ou et al., 2007, Wang, 2007.3.16, Jiang, 2006, Zhang et al., 2006)
            l(3)03477
            (Spradling et al., 1999)
            l(3)2004
            (Gatti and Baker, 1989)
            l(3)88Aa
            (Jarman and Collett, 1998, BDGP Project Members, 1994-1999, Lindsley and Zimm, 1992, Mortin et al., 1992, Szabad and Bryant, 1982, Shearn et al., 1971)
            l(3)A6
            l(3)S086909
            l(3)SG40
            l(3)dsl-6
            (Cohen, 1993)
            l(3)dsl6
            l(3)j1D1
            l(3)j4C7
            mei-P19
            rdx
            (Saha et al., 2022, Bilder et al., 2021, Liu et al., 2021, Karageorgiou et al., 2020, Lepesant et al., 2020, Li et al., 2020, Moschetti et al., 2020, Zhang et al., 2020, FlyBase Genome Annotators, 2019-, Hu et al., 2017.6.13, Tay and Pek, 2017, Clandinin and Owens, 2016-, Kockel et al., 2016, Xu et al., 2016, Chen et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Gurdziel et al., 2015, Bade et al., 2014, de Celis et al., 2013.9.11, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Biehs et al., 2010, Gan et al., 2010, González et al., 2010, Kim et al., 2010, Seong et al., 2010, Baker et al., 2009, González et al., 2008, Chien-Hsiang et al., 2007, Ou et al., 2007, Wang, 2007.3.16, Jiang, 2006)
            Name Synonyms
            CG9924
            Cul3-Hedghog-induced MATH and BTB domain-containing protein
            (Zhang et al., 2009)
            Hh-induced MATH and BTB domain containing protein
            (Zhang et al., 2006)
            Roadkill
            (Xu et al., 2016, Zhou et al., 2013, Zhuang et al., 2009, Hayden and Bosco, 2008)
            hedegehog-induced BTB protein
            (Wang, 2007.3.16)
            hedgehog- induced BTB protein
            (Kim et al., 2010)
            lethal (3) S086909
            meiotic P19
            roadkill
            (Chen et al., 2015, Nakayama et al., 2014, Lawlor et al., 2011, Biehs et al., 2010, Kim et al., 2010, Baker et al., 2009, Wang, 2007.3.16, Kent et al., 2006, Von Ohlen and Hooper, 1999)
            Secondary FlyBase IDs
            • FBgn0011366
            • FBgn0011314
            • FBgn0010801
            • FBgn0004722
            • FBgn0002364
            • FBpp0082336
            • FBtr0082873
            • FBgn0061865
            • FBgn0044329
            • FBgn0038193
            • FBgn0038192
            • FBgn0026625
            • FBgn0086364
            • FBgn0262907
            • FBgn0028076
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 83 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            References (143)