FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdx5
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General Information
Symbol
Dmel\rdx5
Species
D. melanogaster
Name
FlyBase ID
FBal0194657
Feature type
allele
Associated gene
Dmel\rdx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kent et al., 2006)
Progenitor genotype
Cytology
Description

rdx5 encodes for two missense mutations, in exon 5 and exon 10 respectively.

(Kent et al., 2006)

Amino acid replacement: Q193H.

(Kent et al., 2006)

Nucleotide substitution: G?T.

(Kent et al., 2006)

Amino acid replacement: D653V.

(Kent et al., 2006)

Nucleotide substitution: A?T.

(Kent et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:13,982,347..13,982,347 [-]
Nucleotide change:

G13982347T

Reported nucleotide change:

G?T

Amino acid change:

Q193H | rdx-PE

Reported amino acid change:

Q193H

Comment:

Mutation reported in exon 5, which is only found in rdx-RE.

(Kent et al., 2006)
point_mutation
3R:13,969,983..13,969,983 [-]
Nucleotide change:

A13969983T

Reported nucleotide change:

A?T

Amino acid change:

D227V | rdx-PA; D195V | rdx-PB; D224V | rdx-PC; D650V | rdx-PE; D227V | rdx-PF

Reported amino acid change:

D653V

Comment:

Approximate location of rdx5-2 mutation. It was reported as a D653V mutation but there is no D residue at position 653 in the reference sequence. The closest D residues are at 650 and 656. The site of the mutation was reported with respect to rdx-PE.

(Kent et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A few rdx5 homozygote embryos hatch, but none survive beyond first instar.

      Germline clones (lacking both maternal and zygotic rdx) of rdx5 do not generate eggs.

      rdx5 homozygous clones are the same size as their wild-type counterparts in eye and wing imaginal discs.

      Wings filled with unmarked rdx5 clones (28 of 40 wings) exhibit a mild elongation of the anterior compartment.

      rdx5 pupal ommatidia, at 36-42 hours of pupation, exhibit misaligned primary cells (40% of ommatidia) that sometimes fail to enclose cone cells (6%), as well as reduced numbers of cone cells (4%), inappropriate numbers of lattice cells (56%), ommatidial fusions (2%), and misplaced bristles (19%).

      (Kent et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rdx5 is a suppressor of sex comb phenotype of Pc1

      (Strübbe et al., 2011)

      rdx5 is a suppressor of metathoracic leg phenotype of Pc1

      (Strübbe et al., 2011)

      rdx5 is a suppressor of mesothoracic leg phenotype of Pc1

      (Strübbe et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      rdx1

      (Kent et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on embryonic and larval lethality, the following rdx alleles can be ranked from strongest to weakest as follows: rdx5 > rdx6 > rdx4 = rdx1.

      (Kent et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rdx5
      (Strübbe et al., 2011)
      rdx5
      (Bade et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)