FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rdx6
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General Information
Symbol
Dmel\rdx6
Species
D. melanogaster
Name
FlyBase ID
FBal0194658
Feature type
allele
Associated gene
Dmel\rdx
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kent et al., 2006)
Progenitor genotype
Cytology
Description

rdx6 encodes a splice junction mutation (an A to G change in the 23rd nucleotide of the intron between exons 12 and 13).

(Kent et al., 2006)

Nucleotide substitution: A?G.

(Kent et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous rdx6 embryos fail to hatch.

      Embryos derived from rdx6 germline clones (lacking both maternal and zygotic rdx) display a spectrum of developmental defects, ranging from normal patterning (2%), through to a complete failure of cellularization (75%). An intermediate class (23%) includes errors in segmental patterning. It also includes embryos that develop at one end, but that slump at the other end into an amorphous mass, a phenotype most accurately described as roadkill. The failure of cellularization in most rdx6 germline clone embryos reflects severe defects during the early mitotic cycles. Abnormalities include mitotic asynchrony, uneven nuclear spacing, failed anaphase resolution and multipolar mitotic figures.

      rdx6 homozygous clones are the same size as their wild-type counterparts in eye and wing imaginal discs.

      In embryonic rdx6 germline clones mitoses are asynchronous, nuclear spacing is uneven, mitotic figures are highly abnormal, and much of the DNA sinks into the interior of the embryo.

      (Kent et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      rdx6 is a suppressor of sex comb phenotype of Pc1

      (Strübbe et al., 2011)

      rdx6 is a suppressor of metathoracic leg phenotype of Pc1

      (Strübbe et al., 2011)

      rdx6 is a suppressor of mesothoracic leg phenotype of Pc1

      (Strübbe et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      rdx1

      (Kent et al., 2006)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on embryonic and larval lethality, the following rdx alleles can be ranked from strongest to weakest as follows: rdx5 > rdx6 > rdx4 = rdx1.

      (Kent et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      rdx6
      (Strübbe et al., 2011)
      rdx6
      (Bade et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)