FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\lov66
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General Information
Symbol
Dmel\lov66
Species
D. melanogaster
Name
FlyBase ID
FBal0285146
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Imprecise excision of P{GawB}lov91Y resulting in deletion of ~400 bp of DNA downstream of the original insertion, corresponding to intronic/flanking DNA not present in any final lov transcripts.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

Approximate boundaries of a 387 bp deletion resulting from the imprecise excison of P{GawB}lov91Y.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants are viable with normal external adult morphology.

Eggs from homozygous or hemizygous lov66 mothers have a low hatching rate (~20%), irrespective of mating partner genotype. ~80% of the unhatched eggs show no development are are apparently unfertilized. This does not correlate with problems in mating or sperm storage.

Eggs from homozygous or hemizygous lov66 mothers show a range of defects: Class 1 eggs are of normal shape and size, but have a transparent, thin eggshell and dorsal appendages; Class 2 eggs additionally show defects in the final stages of morphogenesis (e.g. aberrant dorsal appendages), often appear unsealed at the anterior, and exhibit incomplete nurse cell dumping; Class 3 eggs are short with sealed eggshells with a cup-shape indentation at the position of the operculum flanked by two stubby dorsal appendages; Class 4 eggs appear normal except for aberrantly shaped dorsal appendages.

During oogenesis in lov66 mothers, defects are observed in vitellogenic and later stages and include malformed dorsal appendages and incomplete nurse cell dumping associated with premature formation of a chorion-like structure between the nurse cells and oocyte.

lov66 larvae grow similarly to controls and show normal behaviour. In uncrowded conditions, homozygous adults emerge in the expected ratio, but the number of emergent adults drops considerably when raised in crowded conditions. Adult climbing behaviour, male courtship and sensory assay performance are essentially normal. In the absence of females, lov66 homozygous males are significantly more active than controls.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)