FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: POLYCOMB GROUP RECRUITERS/DNA-BINDING PROTEINS
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General Information
Name
POLYCOMB GROUP RECRUITERS/DNA-BINDING PROTEINS
Species
D. melanogaster
Symbol
PCG-DNA
FlyBase ID
FBgg0000304
Date last reviewed
2015-07-03
Number of members
7
Description
Description
The Polycomb group (PcG) proteins are epigenetic regulators, best characterized for the repression of Hox gene expression. In Drosophila, PcG proteins repress their target genes by binding to specific DNA elements called Polycomb Response Elements (PREs). PcG DNA binding proteins contribute to the recruitment of Polycomb complexes to PREs. (Adapted from FBrf0228921).
Notes on Group

The SP1/KLF TRANSCRIPTION FACTORS have been shown to bind DNA PRE sequences (FBrf0188187), but their role in PcG recruitment is unclear and so they are not included in this list.

Source Material
The POLYCOMB GROUP RECRUITERS/DNA-BINDING PROTEINS Gene Group has been compiled using the following publication(s): Grossniklaus and Paro, 2014, Lanzuolo and Orlando, 2012, and Muller and Kassis, 2006 .
Key Gene Ontology (GO) terms
Molecular Function
sequence-specific DNA binding
Biological Process
regulation of DNA-templated transcription
Cellular Component
nucleus
Related Gene Groups
Other related group(s)
POLYCOMB GROUP COMPLEXES
SP1/KLF TRANSCRIPTION FACTORS
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
PCG-DNA
POLYCOMB GROUP RECRUITERS/DNA-BINDING PROTEINS
PRE-tethered PcG proteins
Secondary FlyBase ID(s)
References (4)