FB2026_02 , released June 18, 2026
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Citation
Herranz, H., Milan, M. (2006). Notch and affinity boundaries in Drosophila.  BioEssays 28(2): 113--116.
FlyBase ID
FBrf0189787
Publication Type
Review
Abstract
Cells in multicellular organisms often do not intermingle freely with each other. Differential cell affinities can contribute to organizing cells into different tissues. Drosophila limbs and the vertebrate central nervous system are subdivided into compartments. Cells in adjacent compartments do not mix. Cell interactions mediated by Notch-family receptors have been implicated in the specification of these compartment boundaries. Two recent reports analyze the role of the Notch signaling pathway in the generation of an affinity boundary in the Drosophila wing. The first report analyzes the connection between Notch and the actin cytoskeleton. The second report analyzes the differential requirements of Notch and the transcription factor Suppressor of Hairless in generating the affinity boundary.
PubMed ID
16435300
PubMed Central ID
DOI
10.1002/bies.20366
Related Publication(s)
Research paper

Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing.
Major and Irvine, 2005, Development 132(17): 3823--3833 [FBrf0187471]

Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless.
Koelzer and Klein, 2006, Dev. Biol. 289(1): 77--90 [FBrf0190133]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    BioEssays
    Title
    BioEssays
    Publication Year
    1984-
    ISBN/ISSN
    0265-9247
    Data From Reference
    Genes (12)