FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tollo58
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General Information
Symbol
Dmel\Tollo58
Species
D. melanogaster
Name
FlyBase ID
FBal0267037
Feature type
allele
Associated gene
Dmel\Tollo
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Yagi et al., 2010)
Progenitor genotype
TolloEY01776
(Yagi et al., 2010)
Cytology
Description

Imprecise excision of P{EPgy2}TolloEY01776 generates a 3068bp deletion starting from 1508bp upstream of the start codon and extending downstream, but also containing a 7bp insertion (CGAGCAA) at the break point.

(Yagi et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Septic injury of Tollo58 mutant flies results in activation of the innate immune response.

      Tollo58 mutant flies exhibit a slight defect in adult leg formation. They have a normal number of segments but the legs are bent between the tibia and tarsus and thus twisted towards other directions. Flies with a stronger phenotype exhibit malformed femurs and double bending in both tibia and tarsus. The penetrance of this leg phenotype is approximately 20% in Tollo58/Tollo59 mutants.

      (Yagi et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Df(3L)Brd15/Tollo58 is an enhancer of lethal phenotype of Df(2R)BSC22/Toll-7g1-1

      (Yagi et al., 2010)
      Other
      Statement
      Reference

      18wk02701/18wΔ7-35, Df(3L)Brd15/Tollo58 has lethal phenotype

      (Yagi et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      18wΔ7-35/18wk02701; Tollo58/Df(3L)Brd15 double mutants are lethal.

      Toll-7g1-1/Df(2R)BSC22; Tollo58/Df(3L)Brd15 double mutants exhibit ~99% lethality.

      (Yagi et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tollo58
      (Yagi et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)