FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Toll-7g1-1
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General Information
Symbol
Dmel\Toll-7g1-1
Species
D. melanogaster
Name
FlyBase ID
FBal0267034
Feature type
allele
Associated gene
Dmel\Toll-7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-in gene targeting
(Yagi et al., 2010)
Progenitor genotype
Cytology
Description

1565bp deletion, from 406 to 1970bp downstream of the Toll-7 start codon. This deletion causes a frame shift and a new stop codon at codon 140 downstream from the translation start. (Also carries a point mutation downstream of the deletion that would result in the amino acid replacement Q1040term in a wild-type Toll-7 sequence).

(Yagi et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,830,022..19,830,022 [+]
Nucleotide change:

C19830022T

Amino acid change:

Q1040term | Toll-7-PA

Reported amino acid change:

Q1040term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Yagi et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Septic injury of Toll-7g1-1 mutant flies results in activation of the innate immune response.

      (Yagi et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Toll-7g1-1/Df(2R)BSC22; Tollo58/Df(3L)Brd15 double mutants exhibit ~99% lethality.

      Toll-7g1-1/Df(2R)BSC22; Toll-6ex13/Toll-6ex13 double mutants display 72% lethality.

      (Yagi et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Toll-7g1-1
      (Yagi et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)