Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG5888 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\CG5888 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The "Roi" rough eye mutant allele is due to an inversion between 36A and 37A (In(2L)Roi1). The proximal breakpoint is 2.6kb downstream of "amos" and is within the last exon of CG15160. The distal breakpoint is within the first intron of CG5888. Several lines of evidence suggest that the "Roi" phenotype is caused by a gain-of-function allele of "amos" rather than being due to an effect of the inversion on another gene; "amos" is expressed in high levels in a broad area surrounding the morphogenetic furrow in "Roi" third instar larvae (in contrast to wild type), overexpression of "amos" in the eye disc can produce a phenotype similar to that of "Roi" and reversion of the phenotype has been achieved by the insertion of a P-element a few kilobases downstream of "amos" which is associated with a severe reduction of "amos" expression in the eye. In addition, although the location of the In(2L)Roi1 breakpoints means that a chimeric gene could potentially be formed from the 5' portion of CG5888 and the 3' portion of CG15160, this chimeric RNA has not been detected in "Roi" mutants and although dac is also within the inverted segment it does not appear to be implicated in the "Roi" phenotype.