FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tnΔA
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General Information
Symbol
Dmel\tnΔA
Species
D. melanogaster
Name
FlyBase ID
FBal0280149
Feature type
allele
Associated gene
Dmel\tn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Labeau-Dimenna et al., 2012)
Mutagen
minos activity
(Labeau-Dimenna et al., 2012)
Progenitor genotype
Mi{ET1}tnMB03490
(Labeau-Dimenna et al., 2012)
Cytology
Description

Excision of the Mi{ET1}abbaMB03490 element resulting in the tnΔA deletion allele.

(Labeau-Dimenna et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  carcinoma
      modeled by Pvrλ.UASp.Tag:MYC
      (Bawa et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tnΔA homozygous larvae show shorter ventral longitudinal muscles 3 and 4, with sarcomere disorganization; and smaller brains, which is due to smaller brain cells. Pupae are elongate due to the inability to contract body wall muscles.

      (Bawa et al., 2020)

      tnΔA homozygous mutant third instar larvae display deficit in locomotion: the crawling speed, distance from start to finish as well as the total length travelled over time are all significantly reduced in the mutant larvae compared to controls.

      (Brooks et al., 2016)

      tnΔA/Df(2R)Exel6068 pupae are thin and long. Compared to wild type, mutant L3 larval skeletal musculature is thinner and looser. At higher magnification, mutant muscles show myofiber instability and unbundling.

      tn1/tnΔA pupae are thin and long.

      A large proportion of tn1/tnΔA and Df(2R)Exel6068/tnΔA animals die during embryogenesis; either no or very low numbers are lost during larval stages; animals that survive the larval stages die as pupae.

      Myofibrils of tnΔA/Df(2R)Exel6068 larval muscle cells become unbundled directionally: the muscle unbundling is more severe towards the visceral surface of the muscle and retains a more wild type appearance toward the most lateral region of the cell. Also, muscle in older individuals appears to have a greater degree of degeneration than that of younger individuals, suggesting progressive muscle degeneration.

      (Labeau-Dimenna et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      tnΔA/tn1 has visible | pupal stage phenotype, non-enhanceable by Df(3R)Mlp84BP8/+

      (Labeau-Dimenna et al., 2012)

      tnΔA/tn1 has visible | pupal stage phenotype, non-enhanceable by sls[+]/slsj1D7

      (Labeau-Dimenna et al., 2012)
      Suppressed by
      NOT Enhancer of
      Statement
      Reference

      tn[+]/tnΔA is a non-enhancer of visible | pupal stage phenotype of slsg65/slsj1D7

      (Labeau-Dimenna et al., 2012)
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Df(3R)Mlp84BP8/+ or slsj1D7/+ does not enhance the tn1/tnΔA thin pupae phenotype.

      tnΔA/+ does not enhance the slsj1D7/slsg65 thin pupae phenotype.

      (Labeau-Dimenna et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tnΔA is rescued by Scer\GAL4Mef2.PR/tnUAS.cLa

      (Bawa et al., 2020)

      Df(2R)Exel6068/tnΔA is rescued by Scer\GAL4how-24B/tnUAS.cLa

      (Labeau-Dimenna et al., 2012)
      Comments

      Scer\GAL4how-24B-mediated expression of tnScer\UAS.cLa rescues the thin pupal phenotype, the thin and loose larval skeletal musculature, and larval myofiber instability and unbundling phenotypes of tnΔA/Df(2R)Exel6068 animals. Unlike tnΔA/Df(2R)Exel6068 animals, the rescued animals mostly eclose as adults.

      (Labeau-Dimenna et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      thinΔA
      (Baccino-Calace et al., 2022)
      tnΔA
      (Bawa et al., 2020, Vishal et al., 2018, Brooks et al., 2016, Labeau-Dimenna et al., 2012)
      tnΔA
      (Bawa et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)