FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PvrKO2
Open Close
General Information
Symbol
Dmel\PvrKO2
Species
D. melanogaster
Name
FlyBase ID
FBal0304379
Feature type
allele
Associated gene
Dmel\Pvr
Associated Insertion(s)
TI{TI}PvrKO2
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Sears et al., 2003)
gene targeting by homologous recombination
(Sears et al., 2003)
I-SceI
(Sears et al., 2003)
recombination
(Sears et al., 2003)
Progenitor genotype
Associated Insertion(s)
TI{TI}PvrKO2
Cytology
Description

Two tandem partial copies of Pvr are present. A w+mW.hs marker and a single FRT site are present between the two copies.

(Sears et al., 2003)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dp(2;2)PvrKO2 homozygous embryos show shape changes in the central nervous system compared to wild type; the ratio of the distance between the longitudinals and the commissures is less than normal. Hemocytes are largely clustered near the dorsal and anterior regions of the embryo in Dp(2;2)PvrKO2 stage 16 mutants, in contrast to wild-type embryos where they are dispersed throughout the embryo.

      Dp(2;2)PvrKO2 homozygous embryos show shape changes in the central nervous system compared to wild type; the ratio of the distance between the longitudinals and the commissures is less than normal. Dp(2;2)PvrKO2 homozygous embryos have 2.7 +/- 0.2 midline glia per segment, compared to 2.8 +/- 0.2 midline glia per segment in wild-type embryos. Hemocytes are largely clustered near the dorsal and anterior regions of the embryo in Dp(2;2)PvrKO2 stage 16 mutants, in contrast to wild-type embryos where they are dispersed throughout the embryo.

      Homozygous embryos show shape changes in the central nervous system compared to wild type; the ratio of the distance between the longitudinals and the commissures is less than normal. Homozygous embryos have 2.7 +/- 0.2 midline glia per segment, compared to 2.8 +/- 0.2 midline glia per segment in wild-type embryos. Hemocytes are largely clustered near the dorsal and anterior regions of the embryo in stage 16 mutants, in contrast to wild-type embryos where they are dispersed throughout the embryo.

      (Sears et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dp(2;2)PvrKO2
      PvrKO2.3'
      PvrKO2.5'
      PvrKO2
      (Sears et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0150668
      • FBal0150667
      • FBab0037675
      References (1)