FB2026_02 , released June 18, 2026
Allele: Dmel\PvrYFc.λ.UAS.Tag:MYC
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General Information
Symbol
Dmel\PvrYFc.λ.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0197829
Feature type
allele
Associated gene
Dmel\Pvr
Associated Insertion(s)
Carried in Construct
P{UAS-λPVR.YFc}
Key Links
Transgenic product class
inframe_deletion
(Jekely et al., 2005)
missense_variant
(Jekely et al., 2005)
polypeptide_post_translational_processing_variant
(Jekely et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jekely et al., 2005)
missense_variant
(Jekely et al., 2005)
polypeptide_post_translational_processing_variant
(Jekely et al., 2005)
Mutagen
in vitro construct
(Jekely et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-λPVR.YFc}
Cytology
Description

UAS regulatory sequences drive expression of a chimeric protein in which the Pvr extracellular ligand-binding domain has been replaced by the dimerization domain of the bacteriophage λ cI repressor (to induce constitutive dimerization of the encoded protein). A Tag:MYC epitope has been inserted at the junction of the λ and Pvr sequences. In addition, 9 Tyr residues in the Pvr intracellular domain have been mutated to non-phosphorylatable Phe residues (amino acid replacements Y985F, Y998F, Y1008F, Y1046F, Y1048F, Y1264F, Y1271F, Y1278F and Y1286F).

(Jekely et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pvr
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Migration of border cells is less severely impaired in PvrYFc.Scer\UAS.T:λ\cI-DD,T:Hsap\MYC; Scer\GAL4slbo.2.6 animals than in Pvrλ.Scer\UAS.T:Hsap\MYC; Scer\GAL4slbo.2.6 animals.

      (Jekely et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhanced by
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pvf1Scer\UAS.P\T.cRb does not enhance border follicle cell migration defects due to PvrYFc.Scer\UAS.T:λ\cI-DD,T:Hsap\MYC; Scer\GAL4slbo.2.6.

      (Jekely et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PvrYFc.Scer\UAS.T:λ\cI-DD,T:Hsap\MYC
      PvrYFc.λ.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)