FlyBase Allele Report: Dmel\Pvr[GD14375]

General Information

Symbol

Dmel\Pvr^GD14375

Species

D. melanogaster

Name

FlyBase ID

FBal0208185

Feature type

allele

Associated gene

Dmel\Pvr

Associated Insertion(s)

Carried in Construct

P{GD14375}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD14375}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD14375

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates acute myeloid leukemia

modeled by Hsap\HOXA9::Hsap\NUP98^WT.UAS

(Baril et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Larvae expressing Pvr^GD14375 under the control of Scer\GAL4^Hml.Δ have enlarged and disrupted lymph glands with altered posterior signaling centers and significantly more Hml-positive hemocytes, as compared to controls.

(Baril et al., 2017)

Expression of Pvr^GD14375 in the lymph gland cortical zone under the control of Scer\GAL4^Hml.Δ results in premature differentiation of prohemocytes into plasmatocytes and crystal cells.

(Khadilkar et al., 2014)

Adults expressing Pvr^GD14375 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing Pvr^GD14375 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 0% or 10-20% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in planar polarity defects in the orientation of bristles of the notum in 0% or 30-40% of the Scer\GAL4^pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 10-20% or 40-50% of the Scer\GAL4^pnr-MD237-expressing area of the notum, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

14375

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ptth^120F2A, Pvr^GD14375, Scer\GAL4^phtm.PO has increased body size | P-stage phenotype, enhanceable by Alk^JF02668, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Pvr^GD14375, Scer\GAL4^phtm.PO has abnormal developmental rate phenotype, enhanceable by Alk^JF02668, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Pvr^GD14375, Scer\GAL4^phtm.PO has increased body size | P-stage phenotype, enhanceable by Alk^JF02668, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Enhancer of

Statement

Reference

Pvr^GD14375, Scer\GAL4^phtm.PO is an enhancer of abnormal developmental rate phenotype of Alk^JF02668, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Pvr^GD14375, Scer\GAL4^phtm.PO is an enhancer of increased body size | P-stage phenotype of Alk^JF02668, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Pvr^GD14375, Scer\GAL4^phtm.PO is an enhancer of increased mortality during development phenotype of Alk^JF02668, Ptth^120F2A, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Scer\GAL4^phtm.PO/Pvr^GD14375 is an enhancer of abnormal developmental rate phenotype of Ptth^120F2A

(Pan and O'Connor, 2021)

Pvr^GD14375, Scer\GAL4^Hml.Δ is an enhancer of increased cell number | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Pvr^GD14375, Scer\GAL4^Hml.Δ is an enhancer of abnormal size | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

NOT Enhancer of

Statement

Reference

Pvr^GD14375, Scer\GAL4^phtm.PO is a non-enhancer of increased body size | P-stage phenotype of Alk^JF02668, Ptth^120F2A, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

NOT Suppressor of

Statement

Reference

Pvr^GD14375, Scer\GAL4^phtm.PO is a non-suppressor of increased body size | P-stage phenotype of Alk^JF02668, Ptth^120F2A, Scer\GAL4^phtm.PO

(Pan and O'Connor, 2021)

Other

Statement

Reference

Ptth^120F2A, Pvr^GD14375, Scer\GAL4^phtm.PO has increased body size | P-stage phenotype

(Pan and O'Connor, 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Pvr^GD14375, Scer\GAL4^Hml.Δ has embryonic/larval plasmatocyte | third instar larval stage phenotype, suppressible by Arf1^UAS.cKa, Scer\GAL4^Hml.Δ

(Khadilkar et al., 2014)

Pvr^GD14375, Scer\GAL4^Hml.Δ has embryonic/larval crystal cell | third instar larval stage phenotype, suppressible by Arf1^UAS.cKa, Scer\GAL4^Hml.Δ

(Khadilkar et al., 2014)

Enhancer of

Statement

Reference

Pvr^GD14375, Scer\GAL4^Hml.Δ is an enhancer of embryonic/larval lymph gland | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Pvr^GD14375, Scer\GAL4^Hml.Δ is an enhancer of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Other

Statement

Reference

Arf1^UAS.cKa, Pvr^GD14375, Scer\GAL4^Hml.Δ has posterior signaling center of lymph gland primary lobe | third instar larval stage phenotype

(Khadilkar et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Arf79F^Scer\UAS.cKa and Pvr^GD14375 in the cortical zone under the control of Scer\GAL4^Hml.Δ has no effect on niche (posterior signalling center) cell number in the lymph gland primary lobe. The premature differentiation of hemocytes into plasmatocytes and crystal cells seen when Pvr^GD14375 is expressed alone is suppressed.

(Khadilkar et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v43459