FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PvrRNAi.UAS.cRa
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General Information
Symbol
Dmel\PvrRNAi.UAS.cRa
Species
D. melanogaster
Name
FlyBase ID
FBal0159954
Feature type
allele
Associated gene
Dmel\Pvr
Associated Insertion(s)
Carried in Construct
P{UAS-Pvr.RNAi.R}
Key Links
Transgenic product class
RNAi_reagent
(Rosin et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Rosin et al., 2004)
Mutagen
in vitro construct
(Rosin et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Pvr.RNAi.R}
Cytology
Description

Template consists of bases 825-2403 of Pvr in an antisense orientation, followed by bases 1277-2403 in a sense orientation (numbers correspond to bases after the initiator ATG). Expression is under the control of UASt sequences.

(Rosin et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pvr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dorsal mesothoracic disc & actin filament, with Scer\GAL4ptc-559.1

      (Rosin et al., 2004)

      dorsal mesothoracic disc & actin filament & pupa | ectopic, with Scer\GAL4Bx-MS1096

      (Rosin et al., 2004)

      wing, with Scer\GAL4Bx-MS1096

      (Rosin et al., 2004)
      Detailed Description
      Statement
      Reference

      Males expressing PvrdsRNA.Scer\UAS.cRa under the control of Scer\GAL4Abd-B-LDN show normal genitalia rotation.

      (Lee et al., 2011)

      PvrdsRNA.Scer\UAS.cRa with Scer\GAL4Bx-MS1096 or Scer\GAL4ptc-559.1 does not cause any obvious defects in epithelial organisation or polarity in the larval or pupal wing disc, except when the insertion P{UAS-Pvr.dsRNA.R}GOF is used. In P{UAS-Pvr.dsRNA.R}GOF; Scer\GAL4ptc-559.1 wing discs F-actin organization is altered specifically at the basal side of the epithelium. In P{UAS-Pvr.dsRNA.R}GOF; Scer\GAL4Bx-MS1096 pupal wing discs there is an ectopic and highly irregular accumulation of F-actin on the basolateral side of the disc, the resulting wings are blistered.

      (Rosin et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      PvrRNAi.UAS.cRa, Scer\GAL4Bx-MS1096 has wing phenotype, enhanceable by Pvf1UAS.cRa, Scer\GAL4Bx-MS1096

      (Rosin et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      PvrRNAi.UAS.cRa/Scer\GAL4Abd-B-LDN is a non-suppressor of male genitalia phenotype of UvragKG04163/UvragB21

      (Lee et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mild wing phenotype of P{UAS-Pvr.dsRNA.R}GOF/+; Scer\GAL4Bx-MS1096/+ animals is dramatically enhanced by Pvf1Scer\UAS.cRa, leading to a blistered, small and highly folded wings.

      (Rosin et al., 2004)

      The mild wing phenotype of P{UAS-Pvr.dsRNA.R}GOF/+; Scer\GAL4Bx-MS1096/+ animals is dramatically enhanced by Pvf1Scer\UAS.cRa, leading to blistered, small and highly folded wings.

      (Rosin et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      dsRNA is expressed from the template to study the phenotypic consequences of dsRNA interference (RNAi) of the Pvr gene.

      (Rosin et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      PvrRNAi.UAS.cRa
      PvrdsRNA.Scer\UAS.cRa
      PvrdsRNA.UAS.cRa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)