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General Information
Symbol
Dmel\PvrdsRNA.UAS.cRa
Species
D. melanogaster
Name
FlyBase ID
FBal0159954
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Template consists of bases 825-2403 of Pvr in an antisense orientation, followed by bases 1277-2403 in a sense orientation (numbers correspond to bases after the initiator ATG). Expression is under the control of UASt sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dorsal mesothoracic disc & actin filament, with Scer\GAL4ptc-559.1

dorsal mesothoracic disc & actin filament & pupa | ectopic, with Scer\GAL4Bx-MS1096

Detailed Description
Statement
Reference

Males expressing PvrdsRNA.Scer\UAS.cRa under the control of Scer\GAL4Abd-B-LDN show normal genitalia rotation.

PvrdsRNA.Scer\UAS.cRa with Scer\GAL4Bx-MS1096 or Scer\GAL4ptc-559.1 does not cause any obvious defects in epithelial organisation or polarity in the larval or pupal wing disc, except when the insertion P{UAS-Pvr.dsRNA.R}GOF is used. In P{UAS-Pvr.dsRNA.R}GOF; Scer\GAL4ptc-559.1 wing discs F-actin organization is altered specifically at the basal side of the epithelium. In P{UAS-Pvr.dsRNA.R}GOF; Scer\GAL4Bx-MS1096 pupal wing discs there is an ectopic and highly irregular accumulation of F-actin on the basolateral side of the disc, the resulting wings are blistered.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The mild wing phenotype of P{UAS-Pvr.dsRNA.R}GOF/+; Scer\GAL4Bx-MS1096/+ animals is dramatically enhanced by Pvf1Scer\UAS.cRa, leading to a blistered, small and highly folded wings.

The mild wing phenotype of P{UAS-Pvr.dsRNA.R}GOF/+; Scer\GAL4Bx-MS1096/+ animals is dramatically enhanced by Pvf1Scer\UAS.cRa, leading to blistered, small and highly folded wings.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

dsRNA is expressed from the template to study the phenotypic consequences of dsRNA interference (RNAi) of the Pvr gene.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
PvrdsRNA.Scer\UAS.cRa
PvrdsRNA.UAS.cRa
Name Synonyms
Secondary FlyBase IDs
    References (3)