FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Pvr, spri
FlyBase ID
FBig0000098778
Interaction Network
Interactions Browser links
Pvr network
spri network
Reported Interactions
FBrf0187407-4.Y2H
Reference
Jekely et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Pvr 

PVR

bait

fused to GAL4 DNA-binding domain

Pvr 
Pvr 
Pvr 
spri 

Sprint

prey

fused to GAL4 activation domain

spri 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Pvr 
intracellular domain
sufficient binding region
Pvr 
intracellular domain
mutation disrupting interaction
aa 985-1286

\'YFc\', nine Tyr-to-Phe mutations in this region

Pvr 
kinase domain
mutation disrupting interaction

kinase dead

spri 
SH2 domain
sufficient binding region
aa 443-619

\'sprint-b\'

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Jekely et al., 2005)

Two-hybrid system: yeast GAL4-BD/GAL4-AD

(Jekely et al., 2005)
FBrf0222949-14.Y2H
Reference
Bianco et al., 2007
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Pvr 

PVR

bait
Pvr 
Pvr 
spri 

Sprint

prey
spri 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Pvr 
intracellular domain
sufficient binding region
Pvr 
kinase domain
mutation disrupting interaction

kinase dead mutant shows no interaction

spri 
SH2 domain
sufficient binding region
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Two-hybrid system: yeast

(Bianco et al., 2007)

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey was previously cloned reagent).

(Bianco et al., 2007)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)