FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Alk9
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General Information
Symbol
Dmel\Alk9
Species
D. melanogaster
Name
FlyBase ID
FBal0157356
Feature type
allele
Associated gene
Dmel\Alk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Loren et al., 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: E?K.

(Englund et al., 2003)

The E1244K mutation is within the conserved 'PTK' domain of the Alk protein.

(Loren et al., 2003)

Amino acid replacement: E1244K.

(Loren et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,630,449..16,630,449 [-]
Nucleotide change:

G16630449A

Amino acid change:

E1244K | Alk-PA; E1244K | Alk-PB

Reported amino acid change:

E1244K

Comment:

Site of nucleic acid difference inferred by FlyBase based on reported amino acid change

(Englund et al., 2003, Loren et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurofibromatosis
      modeled by Nf1E2
      (Walker et al., 2013, Gouzi et al., 2011)
      modeled by Nf1E2, Nf1P1
      (Moscato et al., 2020)
      ameliorates  neurofibromatosis 1
      modeled by Nf1E2, Nf1P2
      (Durkin et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      axon & photoreceptor cell R8 | somatic clone

      (Bazigou et al., 2007)
      Detailed Description
      Statement
      Reference

      Alk9 heterozygous pupae are normal in size.

      (Gouzi et al., 2011)

      R8 axons in mosaic adults with Alk9 in the lamina target neurons exhibit thickened terminals and fasciculate with R7/R8 axons in adjacent columns or fail to extend into the medulla neuropil.

      (Bazigou et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Alk9/Alk[+] is a suppressor | partially of decreased sleep | larval stage phenotype of Nf1P2/Nf1E2

      (Durkin et al., 2023)

      Alk9 is a suppressor of decreased body size | pupal stage phenotype of Nf1E2

      (Walker et al., 2013)

      Alk9/Alk[+] is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Nf1E2

      (Walker et al., 2013)

      Alk9/Alk[+] is a suppressor | partially of abnormal size | pupal stage phenotype of Nf1E2

      (Gouzi et al., 2011)

      Alk9/Alk[+] is a suppressor | partially of abnormal learning | adult stage phenotype of Nf1E2

      (Gouzi et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Alk9/Alk[+] is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Nf1E2

      (Walker et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in mean number of boutons per neuromuscular junction which is seen in Nf1E2 third instar larvae is dominantly suppressed by Alk9.

      (Walker et al., 2013)

      One copy of Alk9 partially suppresses the small pupae phenotype seen in Nf1E2 homozygotes by increasing cell size. The Nf1E2 olfactory learning phenotype is also partially rescued.

      (Gouzi et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: P{neoFRT}42D chromosome.

      (Loren et al., 2003)

      Selected as: a mutant that fails to complement the Df(2R)Alk-21 deficiency.

      (Loren et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (8)